Patents Assigned to Aletheon Pharmaceuticals, Inc.
  • Streptavidin expressed gene fusions and methods of use thereof
    Patent number: 7144991
    Abstract: The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as are vectors encoding the same. Also provided, are methods of using the fusion proteins of the present invention, and in particular, the use of scFvSA fusion proteins as diagnostic markers or as a cell specific targeting agents.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: December 5, 2006
    Assignee: Aletheon Pharmaceuticals, Inc.
    Inventors: Stephen Charles Goshorn, Scott Stoll Graves, Joanne Elaine Schultz, Yukang Lin, James Allen Sanderson, John M. Reno
  • Pretargeting methods and compounds
    Patent number: 7078013
    Abstract: Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: July 18, 2006
    Assignee: Aletheon Pharmaceuticals, Inc.
    Inventors: Donald B Axworthy, Louis J Theodore, Linda M Gustavson, John M Reno
  • Cluster clearing agents
    Patent number: 6908903
    Abstract: Cluster clearing agents (CCAs) and the use thereof are discussed. CCAs are composed of a hepatic clearance directing moiety which directs the biodistribution of a CCA-containing construct to hepatic clearance; and a binding moiety which mediates binding of the CCA to a compound for which rapid hepatic clearance is desired.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: June 21, 2005
    Assignee: Aletheon Pharmaceuticals, Inc.
    Inventors: Louis J. Theodore, Donald B. Axworthy