Patents Assigned to Aleva Neurotherapeutics
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Publication number: 20220266024Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.Type: ApplicationFiled: May 10, 2022Publication date: August 25, 2022Applicant: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
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Patent number: 11344728Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.Type: GrantFiled: May 28, 2019Date of Patent: May 31, 2022Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
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Publication number: 20220161024Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: ApplicationFiled: February 8, 2022Publication date: May 26, 2022Applicant: Aleva NeurotherapeuticsInventors: André MERCANZINI, Zbynek STRUZKA, Jason Jinyu RUAN, Pascal HARBI, Alain JORDAN
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Patent number: 11311718Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: GrantFiled: April 9, 2019Date of Patent: April 26, 2022Assignee: ALEVA NEUROTHERAPEUTICS SAInventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
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Patent number: 11266830Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: GrantFiled: June 15, 2020Date of Patent: March 8, 2022Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
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Publication number: 20220032043Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: October 13, 2021Publication date: February 3, 2022Applicant: Aleva NeurotherapeuticsInventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 11167126Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: August 26, 2019Date of Patent: November 9, 2021Assignee: ALEVA NEUROTHERAPEUTICSInventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 11160975Abstract: The present disclosure discusses a nerve cuff that includes a thin-film elastic mesh with an integrated array of electrodes. The nerve cuff can wrap around a human carotid artery or other tissue to stimulate the autonomic nervous system. The nerve cuff can include a housing that secures the mesh to the carotid artery or other tissue.Type: GrantFiled: February 28, 2019Date of Patent: November 2, 2021Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan
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Patent number: 10966620Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: GrantFiled: May 15, 2015Date of Patent: April 6, 2021Assignee: Aleva Neurotherapeutics SAInventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis
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Patent number: 10702692Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.Type: GrantFiled: March 2, 2018Date of Patent: July 7, 2020Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
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Patent number: 10441779Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: June 22, 2018Date of Patent: October 15, 2019Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 10201707Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.Type: GrantFiled: January 23, 2018Date of Patent: February 12, 2019Assignee: ALEVA NEUROTHERAPEUTICSInventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 10065031Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: September 30, 2016Date of Patent: September 4, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 10004895Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: September 30, 2016Date of Patent: June 26, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 9925376Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.Type: GrantFiled: February 1, 2017Date of Patent: March 27, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 9889304Abstract: The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components that form a leadless stimulator implantation kit.Type: GrantFiled: February 7, 2017Date of Patent: February 13, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventor: Andre Mercanzini
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Patent number: 9572985Abstract: The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components that form a leadless stimulator implantation kit.Type: GrantFiled: June 27, 2016Date of Patent: February 21, 2017Assignee: ALEVA NEUROTHERAPEUTICSInventor: Andre Mercanzini
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Patent number: 9474894Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: August 27, 2014Date of Patent: October 25, 2016Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 9403011Abstract: The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components that form a leadless stimulator implantation kit.Type: GrantFiled: August 27, 2014Date of Patent: August 2, 2016Assignee: Aleva NeurotherapeuticsInventor: Andre Mercanzini