Patents Assigned to Aleva Neurotherapeutics
  • Publication number: 20220266024
    Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.
    Type: Application
    Filed: May 10, 2022
    Publication date: August 25, 2022
    Applicant: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
  • Patent number: 11344728
    Abstract: The present disclosure describes systems and methods for recording electrical activity, such as local field potentials. The system can include a recording patch that is placed inline between an implanted neurological lead and an implantable pulse stimulator. The recording patch can include recording and amplification circuitry that detects, records, and amplifies electrical activity (also referred to as signals) from a target site. The system can be used to select over which of the lead's electrodes therapeutic stimulations are delivered.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: May 31, 2022
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Dransart, Khoa Nguyen
  • Publication number: 20220161024
    Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.
    Type: Application
    Filed: February 8, 2022
    Publication date: May 26, 2022
    Applicant: Aleva Neurotherapeutics
    Inventors: André MERCANZINI, Zbynek STRUZKA, Jason Jinyu RUAN, Pascal HARBI, Alain JORDAN
  • Patent number: 11311718
    Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: April 26, 2022
    Assignee: ALEVA NEUROTHERAPEUTICS SA
    Inventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
  • Patent number: 11266830
    Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: March 8, 2022
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
  • Publication number: 20220032043
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 3, 2022
    Applicant: Aleva Neurotherapeutics
    Inventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 11167126
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: November 9, 2021
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 11160975
    Abstract: The present disclosure discusses a nerve cuff that includes a thin-film elastic mesh with an integrated array of electrodes. The nerve cuff can wrap around a human carotid artery or other tissue to stimulate the autonomic nervous system. The nerve cuff can include a housing that secures the mesh to the carotid artery or other tissue.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: November 2, 2021
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan
  • Patent number: 10966620
    Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: April 6, 2021
    Assignee: Aleva Neurotherapeutics SA
    Inventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis
  • Patent number: 10702692
    Abstract: The present disclosure describes an implantable lead device that includes an internal support comb. The support comb can include one or more faces that enable the alignment, routing, and holding of the lead device's internal wires. The support comb can enable the interconnection of the wires with to the microelectrode film that includes the lead device's electrodes.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: July 7, 2020
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Zbynek Struzka, Jason Jinyu Ruan, Pascal Harbi, Alain Jordan
  • Patent number: 10441779
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 15, 2019
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 10201707
    Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: February 12, 2019
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 10065031
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: September 4, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 10004895
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: June 26, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 9925376
    Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: March 27, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 9889304
    Abstract: The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components that form a leadless stimulator implantation kit.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: February 13, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventor: Andre Mercanzini
  • Patent number: 9572985
    Abstract: The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components that form a leadless stimulator implantation kit.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: February 21, 2017
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventor: Andre Mercanzini
  • Patent number: 9474894
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: October 25, 2016
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 9403011
    Abstract: The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components that form a leadless stimulator implantation kit.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: August 2, 2016
    Assignee: Aleva Neurotherapeutics
    Inventor: Andre Mercanzini