Patents Assigned to Alexion Pharmaceuticals, Inc.
  • Patent number: 12268733
    Abstract: The disclosure features methods for treating at least one symptom of neurofibromatosis type 1, treating at least one symptom of dystrophic scoliosis, or inducing bone healing by administering a soluble alkaline phosphatase (sALP) to the patient.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: April 8, 2025
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventor: Anna Petryk
  • Publication number: 20250090528
    Abstract: Disclosed herein are methods for treating lupus nephritis (LN) and/or immunoglobulin A (IgA) nephropathy in a subject. The methods include administering to the subject a therapeutically effective amount of a small molecule complement factor D inhibitor.
    Type: Application
    Filed: October 13, 2022
    Publication date: March 20, 2025
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Nader Najafian, Katherine Gayle Garlo, Steven David Podos
  • Publication number: 20250082674
    Abstract: This disclosure relates to methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD). This disclosure also relates to methods of sequestering copper in a subject or of mobilizing copper into plasma in a subject.
    Type: Application
    Filed: August 17, 2022
    Publication date: March 13, 2025
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Brian Meltzer, Eugene Scott Swenson, Wei-Jian Pan, Scott Edward Moseley, Ryan Pelto, Adam Quicquaro
  • Patent number: 12240893
    Abstract: Provided are methods for clinical treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) comprising administering to the patient an anti-C5 antibody, or antigen binding fragment thereof, wherein the anti-C5 antibody, or antigen binding fragment thereof, is administered (or is for administration) subcutaneously according to a particular clinical dosage regimen (i.e., at a particular dose amount and according to a specific dosing schedule). In one embodiment, the patient has previously been treated with eculizumab (Soliris®).
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: March 4, 2025
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Lori Volles, Rajendra Pradhan, Douglas L. Sheridan, Marc Vallee, Xiang Gao
  • Publication number: 20250066296
    Abstract: The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.
    Type: Application
    Filed: December 13, 2022
    Publication date: February 27, 2025
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Akihiro Hashimoto, Avinash Phadke, Sankappa Rai U, Prabu Chandran
  • Patent number: 12233088
    Abstract: Methods for treating Wilson Disease with bis-choline tetrathiomolybdate therapy are provided. The methods may include administering 15 mg or between 30 and 90 mg of bis-choline tetrathiomolybdate once daily to a patient exhibiting NCCcorrected, alanine aminotransferase (ALT), hemoglobin, platelets, or neutrophils levels meeting specified criteria. The methods may include modifying treatment by decreasing or increasing the daily dose of bis-choline tetrathiomolybdate or discontinuing treatment for a period of time.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: February 25, 2025
    Assignee: Alexion Pharmaceutical, Inc.
    Inventors: Carl Bjartmar, Karl-Heinz Weiss, Michael Schilsky, Frederick Askari, Anna Czlonkowska, Peter Ferenci, Peter Hedera, Aftab Ala
  • Publication number: 20250051339
    Abstract: The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof. The methods involve subjecting an intermediate in the synthesis of a complement factor D inhibitor to a t-butyl ester deprotection reaction using a weak base.
    Type: Application
    Filed: December 13, 2022
    Publication date: February 13, 2025
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventor: Akihiro Hashimoto
  • Patent number: 12221473
    Abstract: The disclosure provides engineered polypeptides that specifically bind to human complement component C5 and/or serum albumin. The disclosure also provides fusion proteins comprising such engineered polypeptides, wherein such fusion proteins may be multivalent and multi-specific fusion proteins. The disclosure further provides nucleic acid molecules that encode such engineered polypeptides or fusion proteins, and methods of making such engineered polypeptides or fusion proteins. The disclosure further provides pharmaceutical compositions that comprise such engineered polypeptides or fusion proteins, and methods of treatment using such engineered polypeptides or fusion proteins.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: February 11, 2025
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Bridget Puffer, Julian Chandler, Nimish Gera, Douglas L. Sheridan, Siddharth Jindal, Paul P. Tamburini
  • Patent number: 12195774
    Abstract: The present disclosure relates to antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. In one embodiment, the derivatives described herein lack or have reduced intrinsic coagulant activity.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: January 14, 2025
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Pamela B. Conley, Genmin Lu, Leonard G. Presta, John T. Curnutte
  • Patent number: 12150942
    Abstract: Compositions and methods for treating multiple myeloma (MM), acute myeloid lymphoma (AML) or a myeloproliferative disease (MPD) in a human patient in need thereof. The methods entail administering to the patient an effective amount of cerdulatinib.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: November 26, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Gregory Coffey, Jiajia Feng
  • Patent number: 12139533
    Abstract: The present disclosure provides stable liquid pharmaceutical formulations comprising anti-CD200 antibodies or antigen-binding fragments thereof, and articles of manufacture and kits containing the formulations. Also featured are methods of using the formulations in cancer and autoimmune therapies, and for preventing, delaying or treating cell, tissue, or organ transplant rejection.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: November 12, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Dino Miano, Bruce Mason
  • Patent number: 12128101
    Abstract: Provided are methods for clinical treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) and Atypical Hemolytic Uremic Syndrome (aHUS) using an anti-C5 antibody, or antigen binding fragment thereof.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: October 29, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Lori Payton, Scott T. Rottinghaus, Rajendra Pradhan, Andrew Damokosh, Xiang Gao
  • Publication number: 20240353394
    Abstract: The present disclosure is directed to methods of identifying a test compounds for treating sickle cell disease (SCD), ?-thalassemia (BT), or sickle cell BT. The methods involved contacting a test sample including cells with heme, serum, and a test compound, and measuring a biological phenomena including (1) deposition of a complement factor on the cells in the test sample; or (2) effect(s) of the complement factor deposition of (1) on target effector cells, where an attenuation in the biological phenomena in the test sample compared to the biological phenomena in a reference standard is indicative that the test compound is effective in treating sickle cell disease (SCD), -thalassemia (BT), or sickle cell BT.
    Type: Application
    Filed: August 18, 2022
    Publication date: October 24, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Roxanne Cofiell, Sung-Kwon Kim
  • Publication number: 20240343786
    Abstract: The present disclosure relates to methods, uses, and compositions for the treatment of Sickle cell disease (SCD), beta thalassemia (BT), or sickle cell BT. More specifically, the disclosure concerns the treatment of patients having SCD. BT, or sickle cell BT using a complement C5 inhibitor, such as an anti-C5 antibody or fragment thereof, a nucleic acid molecule, a peptide, a small molecule, or an aptamer.
    Type: Application
    Filed: August 18, 2022
    Publication date: October 17, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Sung-Kwon Kim, Stephanie L. Beq
  • Publication number: 20240343787
    Abstract: The present invention relates to methods, uses, and compositions for the treatment of Sickle cell disease (SCD), beta thalassemia (BT), sickle cell BT. More specifically, the invention concerns the treatment of patients having SCD, BT, or sickle cell BT using a complement pathway component (e.g., Factor P (properdin)) inhibitor, such as an antibody or fragment thereof, a nucleic acid molecule, a peptide, a small molecule, or an aptamer, among others.
    Type: Application
    Filed: August 18, 2022
    Publication date: October 17, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Sung-Kwon Kim, Stephanie L. Beq
  • Publication number: 20240342127
    Abstract: Disclosed are methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are compositions comprising bis-choline tetrathiomolybdate for use in the treatment of a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are uses of a composition comprising bis-choline tetrathiomolybdate for the manufacture of a medicament for treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old.
    Type: Application
    Filed: September 6, 2022
    Publication date: October 17, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Eugene Scott Swenson, Wei-Jian Pan
  • Patent number: 12083169
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: September 10, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Walter C. Voegtli, Yuhong Wu, Jonathan Monteleone, Tatyana Mezhebovsky, Eric Falcone, Yang Guo
  • Patent number: 12076376
    Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: September 3, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventor: Anthony Quinn
  • Publication number: 20240279320
    Abstract: Provided are dosages and methods for clinical treatment of dermatomyositis (DM), particularly severe and/or refractory DM, in human patients using an anti C5 antibody, or antigen binding fragment thereof (e.g., such as ravulizumab (ULTOMIRIS®)).
    Type: Application
    Filed: June 9, 2022
    Publication date: August 22, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Laura Marie Gault, Adrian Markus Kielhorn, Sanjay Nandkumar Rakhade, Usharbudh Shivraj Sohur
  • Publication number: 20240262877
    Abstract: Described herein are fusion proteins which include factor H catalytic domains and may include VHH domains, factor H-related protein 5 domains, or integrin binding domains, and the use of such fusion proteins in methods of treatment of diseases mediated by complement alternative pathway activation or dysregulation, for example, kidney diseases.
    Type: Application
    Filed: May 24, 2022
    Publication date: August 8, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Keith Bouchard, Jeffrey William Hunter, Bruce A. Andrien, Jr., Sung-Kwon Kim, Julian Chandler