Abstract: The process for the production of form I of anhydrous terazosin monohydrochloride consists of heating terazosin suspended in a mixture made by methanol and a solvent selected from C.sub.2 to C.sub.6, straight or branched alcohols, esters of C.sub.1 -C.sub.8 aliphatic carboxylic acids with straight or branched C.sub.1 to C.sub.8 alcohols, C.sub.3 to C.sub.8 aliphatic ketones, C.sub.4 to C.sub.8 straight branched or cyclic aliphatic ethers, aliphatic amides and aliphatic nitriles with a methanol solution of hydrochloric acid.
Type:
Grant
Filed:
October 20, 1997
Date of Patent:
January 12, 1999
Assignee:
Alfa Chemicals Italiana S.r.l.
Inventors:
Vincenzo Cannata, Tiziano Ferrario, Barbara Galbiati
Abstract: The process for the production of the form I of the terazosin monohydrochloride anhydrous consists of treating at the boiling temperature terazosin monohydrochloride dihydrate with a mixture of methanol and a solvent selected from C.sub.2 -C.sub.6 straight or branched alcohols, the esters of the C.sub. -C.sub.8 carboxylic aliphatic acids with C.sub.1 -C.sub.8 straight or branched alcohols, C.sub.3 to C.sub.8 aliphatic ketones, C.sub.4 to C.sub.8 straight, branched or cyclic aliphatic ethers, aliphatic amides and the aliphatic nitriles.
Type:
Grant
Filed:
October 21, 1997
Date of Patent:
January 5, 1999
Assignee:
ALFA Chemicals Italiana S.R.L.
Inventors:
Vincenzo Cannata, Tiziano Ferrario, Barbara Galbiati