Patents Assigned to Alfa Wassermann
  • POLYMORPHIC FORMS ALPHA, BETA AND GAMMA OF RIFAXIMIN
    Publication number: 20110160448
    Abstract: Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ?, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
    Type: Application
    Filed: March 4, 2011
    Publication date: June 30, 2011
    Applicant: ALFA WASSERMANN, S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN
    Publication number: 20110160449
    Abstract: Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ?, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
    Type: Application
    Filed: March 4, 2011
    Publication date: June 30, 2011
    Applicant: ALFA WASSERMANN, S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMORPHIC FORMS ALPHA, BETA, AND GAMMA OF RIFAXIMIN
    Publication number: 20110152516
    Abstract: Crystalline polymorphous forms of rifaximin (INN), referred to as rifaximin ? and rifaximin ?, and a poorly crystalline form referred to as rifaximin ?, useful in the production of medicaments containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a fixed temperature and for a fixed period of time, followed by a drying under controlled conditions until reaching a precise water content in the end product, are the object of the invention.
    Type: Application
    Filed: March 4, 2011
    Publication date: June 23, 2011
    Applicant: ALFA WASSERMANN, S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • RIFAXIMIN COMPOSITIONS AND METHOD OF USE
    Publication number: 20110086871
    Abstract: Forms of rifaximin (INN) antibiotic, such as the poorly crystalline form named rifaximin ? are described, along with the production of medicinal preparations containing rifaximin for oral and topical use.
    Type: Application
    Filed: November 29, 2010
    Publication date: April 14, 2011
    Applicant: ALFA WASSERMANN, S.P.A.
    Inventors: Giuseppe Claudio VISCOMI, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • Processes for the production of polymorphic forms of rifaximin
    Patent number: 7923553
    Abstract: Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ?, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: April 12, 2011
    Assignee: Alfa Wassermann, S.p.A.
    Inventors: Giuseppe Claudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • Use of polymorphic forms of rifaximin for medical preparations
    Patent number: 7915275
    Abstract: The present invention relates to Rifaximin polymorphic forms ?, ? and ?, to their use in medicinal preparations for the oral or topical route and to therapeutic methods using them.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: March 29, 2011
    Assignee: Alfa Wassermann, S.p.A.
    Inventors: Giuseppe C. Viscomi, Manuela Campana, Donatella Confortini, Miriam Barbanti, Fiorella Calanni
  • Pharmaceutical compositions comprising polymorphic forms ?, ?, and ? of rifaximin
    Patent number: 7906542
    Abstract: Crystalline polymorphous forms of rifaximin (INN), referred to as rifaximin ? and rifaximin ?, and a poorly crystalline form referred to as rifaximin ?, useful in the production of medicaments containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a fixed temperature and for a fixed period of time, followed by a drying under controlled conditions until reaching a precise water content in the end product, are the object of the invention.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: March 15, 2011
    Assignee: Alfa Wassermann, S.p.A.
    Inventors: Giuseppe Claudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • Polymorphic forms ?, ? and ? of rifaximin
    Patent number: 7902206
    Abstract: Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ?, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: March 8, 2011
    Assignee: Alfa Wassermann, S.p.A.
    Inventors: Giuseppe Claudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • Centrifuge with removable core for scalable centrifugation
    Patent number: 7862494
    Abstract: The present invention relates to a centrifuge apparatus. The centrifuge apparatus is operable at certain predetermined parameters depending upon a product to be separated and is useable with a plurality of rotor assemblies. For example, a first rotor assembly of said plurality of rotor assemblies includes a first core having a first core configuration which is contained within a rotor housing of the first rotor assembly to define a first volume capacity such that the product passing through the first rotor assembly having the first volume capacity during rotation of the first rotor assembly in the centrifuge apparatus achieves a first particle separation of the product.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: January 4, 2011
    Assignee: Alfa Wassermann
    Inventors: Sandra Patricia Merino, Steven J. Dalessio, Robin Roy Louis Rudy Otten
  • Gastroresistant Pharmaceutical Formulations Containing Rifaximin
    Publication number: 20100330129
    Abstract: The object of the invention consists of pharmaceutical formulations containing rifaximin in the shape of microgranules made gastroresistant by an insoluble polymer at pH values between 1.5 and 4.0 and soluble at pH values between 5.0 and 7.5, by their preparation and by their use in the manufacture of medicinal preparations useful in the treatment of inflammatory bowel diseases (IBD) and mainly Crohn's disease.
    Type: Application
    Filed: January 28, 2010
    Publication date: December 30, 2010
    Applicant: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Ernesto Palazzini, Villiam Zamboni, Maria Rosaria Pantaleo
  • Centrifuge with removable core for scalable centrifugation
    Patent number: 7837609
    Abstract: The present invention relates to a centrifuge apparatus. The centrifuge apparatus is operable at certain predetermined parameters depending upon a product to be separated and is useable with a plurality of rotor assemblies. For example, a first rotor assembly of said plurality of rotor assemblies includes a first core having a first core configuration which is contained within a rotor housing of the first rotor assembly to define a first volume capacity such that the product passing through the first rotor assembly having the first volume capacity during rotation of the first rotor assembly in the centrifuge apparatus achieves a first particle separation of the product.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: November 23, 2010
    Assignee: Alfa Wassermann, Inc.
    Inventors: Sandra Patricia Meriño, Steven J. Dalessio, Robin Roy Louis Rudy Otten
  • USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN
    Publication number: 20100010028
    Abstract: Polyols stabilize polymorphous form of rifaximin, in particular the ? form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ? is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
    Type: Application
    Filed: July 31, 2007
    Publication date: January 14, 2010
    Applicant: Alfa Wassermann, S.P.A.
    Inventors: Paola Maffei, Milena Bachetti, Gluseppe Bottoni, Giuseppe Claudio Viscomi
  • Polymorphic forms ?, ?, and ? of rifaximin
    Patent number: 7612199
    Abstract: Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ?, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: November 3, 2009
    Assignee: Alfa Wassermann, S.p.A.
    Inventors: Guiseppe Glaudio Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vicenzo Cannata, Paolo Righi, Goffredo Rosini
  • Gastroresistant Pharmaceutical Formulations Containing Rifaximin
    Publication number: 20090011020
    Abstract: The object of the invention consists of pharmaceutical formulations containing rifaximin in the shape of microgranules made gastroresistant by an insoluble polymer at pH values between 1.5 and 4.0 and soluble at pH values between 5.0 and 7.5, by their preparation and by their use in the manufacture of medicinal preparations useful in the treatment of inflammatory bowel diseases (IBD) and mainly Crohn's disease.
    Type: Application
    Filed: March 6, 2006
    Publication date: January 8, 2009
    Applicant: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Ernesto Palazzini, Villiam Zamboni, Maria Rosaria Pantaleo
  • Applicator of a fluid sample on a substrate
    Patent number: 7435388
    Abstract: Applicator of a fluid sample on a substrate, wherein at least an applying blade substantially of rectangular shape in its turn defining a body of the blade, a tip of the blade and two facing side edges of the blade, wherein each blade has a drain of the body of the blade stretching between the facing side edges of the blade, the drain defining a physical barrier for the fluid sample; and at least one calibrated retention aperture of the fluid sample, put between the tip of the blade and the drain of the blade, the at least one aperture being calibrated in order to keep on its inside an exactly defined amount of fluid sample.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: October 14, 2008
    Assignee: Alfa Wassermann, S.p.A.
    Inventor: Pietro Antonio Nardo
  • Use of polymorphic forms of rifaximin for medical preparations
    Publication number: 20080132530
    Abstract: The present invention relates to Rifaximin polymorphic forms ?, ? and ?, to their use in medicinal preparations for the oral or topical route and to therapeutic methods using them.
    Type: Application
    Filed: October 17, 2007
    Publication date: June 5, 2008
    Applicant: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe C. Viscomi, Manuela Campana, Donatella Confortini, Miriam Barbanti, Fiorella Calanni
  • Polymorphous forms of rifaximin, processes for their production and use thereof in medicinal preparations
    Patent number: 7045620
    Abstract: Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ? have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: May 16, 2006
    Assignee: Alfa Wassermann, S.p.A.
    Inventors: Giuseppe C. Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Denis Severini, Paolo Righi, Goffredo Rosini
  • Polymorphic forms of rifaximin, processes for their production and uses thereof
    Publication number: 20050272754
    Abstract: The present invention relates to rifaximin polymorphic forms ?, ? and ?, the processes for their preparation and the use thereof in the manufacture of medicinal preparations for the oral or topical route.
    Type: Application
    Filed: May 24, 2005
    Publication date: December 8, 2005
    Applicant: ALFA WASSERMANN S.p.A.
    Inventors: Giuseppe Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Paolo Righi, Goffredo Rosini
  • Bifidobacteria and preparations containing them
    Patent number: 6960341
    Abstract: The disclosure refers to biologically pure cultures of two strains of Bifidobacterium Longum named W11 and W11a and deposited at the Belgian Coordinated Collections of Microorganisms (BCCM) that has registered them under the accession numbers LMG P-21586 and LMG P-21587. They are used as probiotics within preparations of pharmaceutical or alimentary products to help the gastrointestinal health and to prevent and treat the intestinal pathologies.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: November 1, 2005
    Assignee: Alfa Wassermann S.p.A.
    Inventors: Claudio Giuseppe Viscomi, Leone Gabriele Rotini, Lorenzo Morelli, Patrizio Ferrari, Maria Rosaria Pantaleo
  • Polymorphous forms of rifaximin, processes for their production and use thereof in medicinal preparations
    Publication number: 20050101598
    Abstract: Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin ? and rifaximin ?, and a poorly crystalline form named rifaximin ? have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.
    Type: Application
    Filed: December 5, 2003
    Publication date: May 12, 2005
    Applicant: ALFA WASSERMANN S.p.A.
    Inventors: Giuseppe Viscomi, Manuela Campana, Dario Braga, Donatella Confortini, Vincenzo Cannata, Denis Severini, Paolo Righi, Goffredo Rosini