Patents Assigned to Alfacell Corporation

RELATED RIBONUCLEASES IN WHICH AN AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE IS PRECEDED BY AT LEAST ONE RESIDUE AT THE N-TERMINUS, AND METHODS OF MAKING THEM RECOMBINANTLY

Publication number: 20100317082

Abstract: New RNases, and methods for making them, are disclosed. Each includes an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue or leader sequence.

Type: Application

Filed: June 1, 2010

Publication date: December 16, 2010

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
RIBONUCLEASE IN WHICH AN AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE IS PRECEDED BY A RESIDUE AT THE N-TERMINUS, AND A METHOD OF MAKING IT RECOMBINANTLY

Publication number: 20100304463

Abstract: A new RNase, and a method for making it, are disclosed. The RNase has an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue.

Type: Application

Filed: May 28, 2010

Publication date: December 2, 2010

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
RIBONUCLEASES IN WHICH AN AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE IS PRECEDED BY AT LEAST ONE RESIDUE AT THE N-TERMINUS, AND METHODS OF MAKING THEM RECOMBINANTLY

Publication number: 20100291657

Abstract: New RNases, and methods of making them, are disclosed. Each includes an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue or leader sequence.

Type: Application

Filed: June 9, 2010

Publication date: November 18, 2010

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an N-terminal leader sequence that is at least one residue long

Patent number: 7763449

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence.

Type: Grant

Filed: November 19, 2008

Date of Patent: July 27, 2010

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Nucleic acid encoding a fusion protein incorporating a cysteinized ribonuclease

Patent number: 7585655

Abstract: A nucleic acid encodes a novel fusion protein. The fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.

Type: Grant

Filed: November 20, 2008

Date of Patent: September 8, 2009

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Nucleic acid encoding cysteinized ribonuclease to which a targeting moiety can be conjugated

Patent number: 7585654

Abstract: A nucleic acid encodes a cysteinized RNase to which a targeting moiety can be conjugated.

Type: Grant

Filed: November 20, 2008

Date of Patent: September 8, 2009

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an n-terminal leader sequence that is at least one residue long

Patent number: 7556951

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in United States Patent U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence.

Type: Grant

Filed: November 18, 2008

Date of Patent: July 7, 2009

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of a known amino acid sequence and an initial N-terminal residue

Patent number: 7556952

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue.

Type: Grant

Filed: November 19, 2008

Date of Patent: July 7, 2009

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an N-terminal leader sequence

Patent number: 7556953

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a leader sequence.

Type: Grant

Filed: November 20, 2008

Date of Patent: July 7, 2009

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
NUCLEIC ACID ENCODING A NOVEL RIBONUCLEASE HAVING AN AMINO ACID SEQUENCE MADE UP OF THE AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE AND AN N-TERMINAL LEADER SEQUENCE

Publication number: 20090111175

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a leader sequence.

Type: Application

Filed: November 20, 2008

Publication date: April 30, 2009

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
NUCLEIC ACID ENCODING A NOVEL RIBONUCLEASE HAVING AN AMINO ACID SEQUENCE MADE UP OF A KNOWN AMINO ACID SEQUENCE AND AN INITIAL N-TERMINAL RESIDUE

Publication number: 20090099348

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue.

Type: Application

Filed: November 19, 2008

Publication date: April 16, 2009

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
NUCLEIC ACID ENCODING A FUSION PROTEIN INCORPORATING A CYSTEINIZED RIBONUCLEASE

Publication number: 20090081778

Abstract: A nucleic acid encodes a novel fusion protein. The fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.

Type: Application

Filed: November 20, 2008

Publication date: March 26, 2009

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
NUCLEIC ACID ENCODING A NOVEL RIBONUCLEASE HAVING AN AMINO ACID SEQUENCE MADE UP OF THE AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE AND AN N-TERMINAL LEADER SEQUENCE THAT IS AT LEAST ONE RESIDUE LONG

Publication number: 20090081776

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence.

Type: Application

Filed: November 19, 2008

Publication date: March 26, 2009

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
NUCLEIC ACID ENCODING A NOVEL RIBONUCLEASE HAVING AN AMINO ACID SEQUENCE MADE UP OF THE AMINO ACID SEQUENCE OF A KNOWN RIBONUCLEASE AND AN N-TERMINAL LEADER SEQUENCE THAT IS AT LEAST ONE RESIDUE LONG

Publication number: 20090081759

Abstract: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in United States Patent U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence.

Type: Application

Filed: November 18, 2008

Publication date: March 26, 2009

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
NUCLEIC ACID ENCODING CYSTEINIZED RIBONUCLEASE TO WHICH A TARGETING MOIETY CAN BE CONJUGATED

Publication number: 20090081777

Abstract: A nucleic acid encodes a cysteinized RNase to which a targeting moiety can be conjugated.

Type: Application

Filed: November 20, 2008

Publication date: March 26, 2009

Applicant: ALFACELL CORPORATION

Inventor: Shailendra K. SAXENA
Cysteinized ribonuclease and targeting moiety conjugated thereto

Patent number: 7473542

Abstract: A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue.

Type: Grant

Filed: June 8, 2007

Date of Patent: January 6, 2009

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Fusion protein incorporating a cysteinized ribonuclease

Patent number: 7442535

Abstract: A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.

Type: Grant

Filed: June 8, 2007

Date of Patent: October 28, 2008

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
Cysteinized ribonuclease and targeting moiety conjugated thereto

Patent number: 7442536

Abstract: A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue.

Type: Grant

Filed: June 8, 2007

Date of Patent: October 28, 2008

Assignee: Alfacell Corporation

Inventor: Shailendra K. Saxena
RIBONUCLEASES AND METHODS OF MAKING THEM RECOMBINANTLY

Publication number: 20080033151

Abstract: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are active against human carcinoma cells.

Type: Application

Filed: June 8, 2007

Publication date: February 7, 2008

Applicant: Alfacell Corporation

Inventor: Shailendra Saxena
RIBONUCLEASES AND METHODS OF MAKING THEM RECOMBINANTLY

Publication number: 20070243605

Abstract: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are active against human carcinoma cells.

Type: Application

Filed: June 8, 2007

Publication date: October 18, 2007

Applicant: Alfacell Corporation

Inventor: Shailendra Saxena

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