Patents Assigned to ALFAMA, INC.
  • Ruthenium carbon monoxide releasing molecules and uses thereof
    Patent number: 9611286
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: April 4, 2017
    Assignee: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J. L. Bernardes, Maria M. Mota, Carlos C. Romão
  • RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20160237105
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Application
    Filed: May 13, 2015
    Publication date: August 18, 2016
    Applicant: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J.L. Bernardes, Maria M. Mota, Carlos C. Romão
  • CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20160137679
    Abstract: Provided herein are novel carbon-monoxide releasing molecules (CO-RMs) of the Formula (I): and esters, amides, salts, solvates and hydrates thereof; wherein R1 and R2 are as described herein. Also provided are pharmaceutical compositions comprising these compounds, methods of their preparation, and their use in the treatment of liver disease and inflammation.
    Type: Application
    Filed: September 8, 2015
    Publication date: May 19, 2016
    Applicant: Alfama, Inc.
    Inventors: Walter Anton Blättler, Carlos J.R.C. Romão, Sandra Sofia Pereira Rodrigues, Lukas Adrian Kromer, Leo Edmond Otterbein, David John Gallo
  • RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20150322105
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 12, 2015
    Applicant: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J.L. Bernardes, Maria M. Mota, Carlos C. Romão
  • Carbon monoxide releasing molecules and uses thereof
    Patent number: 9163044
    Abstract: Provided herein are novel carbon-monoxide releasing molecules (CO-RMs) of the Formula (I): and esters, amides, salts, solvates and hydrates thereof; wherein R1 and R2 are as described herein. Also provided are pharmaceutical compositions comprising these compounds, methods of their preparation, and their use in the treatment of liver disease and inflammation.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: October 20, 2015
    Assignee: Alfama, Inc.
    Inventors: Walter Anton Blättler, Carlos J. R. C. Romão, Sandra Sofia Pereira Rodrigues, Lukas Adrian Kromer, Leo Edmond Otterbein, David John Gallo
  • Ruthenium carbon monoxide releasing molecules and uses thereof
    Patent number: 9062089
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Grant
    Filed: July 21, 2012
    Date of Patent: June 23, 2015
    Assignee: Alfama, Inc.
    Inventors: Ana Pamplona, Gonçalo J. L. Bernardes, Maria M. Mota, Carlos C. Romão
  • CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20140142176
    Abstract: Provided herein are novel carbon-monoxide releasing molecules (CO-RMs) of the Formula (I): and esters, amides, salts, solvates and hydrates thereof; wherein R1 and R2 are as described herein. Also provided are pharmaceutical compositions comprising these compounds, methods of their preparation, and their use in the treatment of liver disease and inflammation.
    Type: Application
    Filed: April 19, 2012
    Publication date: May 22, 2014
    Applicant: ALFAMA, INC.
    Inventors: Walter Anton Blättler, Carlos J.R.C. Romäo, Sandra Sofia Pereira, Lukas Adrian Kromer, Leo Edmond Otterbein, David John Gallo