Patents Assigned to Alfred E. Mann Foundation
  • Publication number: 20190338100
    Abstract: The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care/on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.
    Type: Application
    Filed: May 14, 2019
    Publication date: November 7, 2019
    Applicants: Monolythix, Inc., Alfred E. Mann Foundation for Scientific Research
    Inventors: Keith A. Oberg, Mark D. Dobbs, Ekaterina Tkatchouk, Scott P. Layne, Milton Lee
  • Patent number: 10449377
    Abstract: Systems and devices for a high-efficiency magnetic link for implantable devices are disclosed herein. These devices can include a charging coil located in the implantable device and a charging coil located in a charge head of a charger. The charging coils can each include an elongate core and wire windings wrapped around a longitudinal axis of the elongate core. The charging coil of the charge head can be attached to a rotatable mount, which can be used to align the longitudinal axis of the charging coil of the charge head with longitudinal axis of the implantable device such that the axes of the charging coils are parallel.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 22, 2019
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, Glen A. Griffith
  • Patent number: 10447083
    Abstract: A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: October 15, 2019
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, James H. Wolfe, Manish Khemani
  • Publication number: 20190290455
    Abstract: Skin patch sensors for monitoring and/or affecting body parameters, with alignment, positioning and attachment using magnets. The repeated use of releasable adhesive layers to retain skin patch sensors on skin can cause skin irritation, which can be reduced by rotating a skin patch between attachment times around a magnetically coupled pivot point. Skin patch sensors can be configured with internal coils to inductively couple to external power transmitting and communications coils with solenoids in anti-Helmholtz configurations.
    Type: Application
    Filed: March 22, 2019
    Publication date: September 26, 2019
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEA RCH
    Inventors: BRIAN R. DEARDEN, JOHN G. PETROVICH
  • Publication number: 20190282805
    Abstract: An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 19, 2019
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Siegmar Schmidt, Boon Khai Ng
  • Patent number: 10369362
    Abstract: An apparatus and method is related to providing sensing functions that are similar to “human touch” when located in a prosthetic device such as a BION microstimulator that is implanted in a patient. The apparatus includes a power circuit, a communication circuit and a sensor circuit. The power circuit provides power to the communication circuit and the sensor circuit. The sensor cooperates with the communication circuit, which communicates to the brain. The sensor uses various techniques to detect changes in the environment for the surrounding tissue using criteria such as reflectivity, impedance, conductivity, return signal spectrum, return signal rate and return signal phase to name a few. For example, the impedance observed by the sensor changes when: the skin tissue is deformed around the sensor, or when the skin is surrounded by water. The sensory information is interpreted by the brain as an analog of touch or feel.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 6, 2019
    Assignee: The Alfred E. Mann Foundation for Scientific Research
    Inventors: Lawrence J. Karr, Joseph H. Schulman
  • Patent number: 10335089
    Abstract: Biocompatible stiffness enhanced pliable electrically conductive filaments configured for contact with living tissue and electrical communication with such tissue. The pliability of the filaments allows the distal end of the filaments to remain at the original site of penetration into the tissue despite the movement of the tissue relative to their surrounding environment. To temporarily stiffen the filaments, a soluble stiffness enhancing coating is disposed over the filaments. The coating may be in the form of a liquid which dries to a solid state after being applied to the filaments and renders the filaments sufficiently rigid such that under appropriate force, the filaments are capable of penetrating into dense tissue. Once in place, the stiffness enhancing coating dissolves due to contact with body fluids, the filaments, in the absence of such a coating, return to their initial pliability.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: July 2, 2019
    Assignee: The Alfred E. Mann Foundation for Scientific Research
    Inventors: Joseph H. Schulman, David L. Hankin
  • Patent number: 10336881
    Abstract: The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care/on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: July 2, 2019
    Assignees: Alfred E. Mann Foundation for Scientific Research, Monolythix, Inc.
    Inventors: Keith A. Oberg, Mark D. Dobbs, Ekaterina Tkatchouk, Scott P. Layne, Milton Lee
  • Publication number: 20190143110
    Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
    Type: Application
    Filed: January 11, 2019
    Publication date: May 16, 2019
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Harshit Suri, Joseph L. Calderon, Gregory Frederick Molnar, George S. Goding, JR., Alanie Atyabi, Siegmar Schmidt, William Dai, Brian Dearden, Desmond B. Keenan
  • Patent number: 10226612
    Abstract: The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: March 12, 2019
    Assignee: Alfred E. Mann Foundation For Scientific Research
    Inventors: Guangqiang Jiang, Tom He
  • Publication number: 20190060646
    Abstract: An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
    Type: Application
    Filed: August 30, 2018
    Publication date: February 28, 2019
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, Joseph L. Calderon
  • Publication number: 20190015664
    Abstract: A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
    Type: Application
    Filed: May 15, 2018
    Publication date: January 17, 2019
    Applicant: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventor: EDWARD K.F. LEE
  • Publication number: 20180318578
    Abstract: An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
    Type: Application
    Filed: April 30, 2018
    Publication date: November 8, 2018
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, William Dai
  • Patent number: 10086184
    Abstract: The various implementations described herein include methods used to manufacture a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the method includes providing a tubular structure having an outer surface and providing a coil having an outer surface and comprised of a plurality of loops. The method further includes joining at least a portion of the outer surface of the coil to the outer surface of the tubular structure.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: October 2, 2018
    Assignee: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Guangqiang Jiang, Tom He
  • Publication number: 20180256030
    Abstract: A medical system and method of communicating between a telemetry controller and a plurality of medical devices implanted within a patient is provided. Communication links are respectively established between the telemetry controller and the implanted medical devices. The communication links are respectively amplitude modulated by the implanted medical devices at modulation levels using load modulation. Received signal strength indicators (RSSIs) of the amplitude modulated communication links for the implanted medical devices are measured. A variation of the RSSIs is decreased by modifying, based on the measured RSSIs, at least one modulation level at which the respective at least one communication link is amplitude modulated by the respective implanted medical device(s).
    Type: Application
    Filed: February 28, 2018
    Publication date: September 13, 2018
    Applicant: The Alfred E. Mann Foundation for Scientific Research
    Inventors: EDWARD K. F. LEE, HARSHIT R. SURI
  • Publication number: 20180220891
    Abstract: A medical system and method of communicating between a telemetry controller and medical devices is provided. Coupling coefficients between a primary coil of the telemetry controller and secondary coils of the medical devices differ from each other. A primary carrier signal is applied to the primary coil, thereby respectively inducing secondary carrier signals on the secondary coils. An amplitude of the secondary carrier signal is measured on each of the secondary coils. The envelope of each secondary carrier signal is modulated in accordance with data, thereby inducing modulation of the envelope of the primary carrier signal for the implanted medical devices. The secondary carrier signal envelopes are modulated based on the measured amplitudes of the respective secondary carrier signals.
    Type: Application
    Filed: February 7, 2018
    Publication date: August 9, 2018
    Applicant: The Alfred E. Mann Foundation for Scientific Resea rch
    Inventors: EDWARD K. F. LEE, HARSHIT R. SURI
  • Publication number: 20180221660
    Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 9, 2018
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Harshit Suri, Joseph L. Calderon, Gregory Frederick Molnar, George S. Goding, Jr., Alanie Atyabi, Siegmar Schmidt, William Dai, Brian Dearden, Desmond B. Keenan
  • Patent number: 10033296
    Abstract: Systems and methods for rectifying and regulating an input voltage are disclosed. A biasing circuit is configured to generate a biasing voltage greater than the maximum value of the input voltage minus a forward bias voltage of a p-n junction diode and apply the biasing voltage to the body terminal of a MOSFET. The biasing circuit may generate the biasing voltage by rectifying the input voltage. A control circuit is configured to generate a gate voltage based on the rectified and regulated output voltage and apply the gate voltage to the gate terminal of the MOSFET.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: July 24, 2018
    Assignee: The Alfred E. Mann Foundation for Scientific Research
    Inventor: Edward K. F. Lee
  • Patent number: 10029090
    Abstract: A multi-branch stimulation electrode is disclosed herein. The multi-branch stimulation electrode can include a plurality of branches that extend from a hub. The branches can each include one or several stimulation contacts that can deliver an electrical current to tissue contacting the stimulation contacts. The stimulation contacts can be electrically connected with the lead. The lead can extend from the hub and can be connected with the pulse generator. The branches can include features to facilitate implantation including, for example, one or several removable stiffening elements.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: July 24, 2018
    Assignee: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian M. Shelton, Morten Hansen
  • Publication number: 20180178015
    Abstract: In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 28, 2018
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, Harshit Suri, Edward K. F. Lee