Abstract: A method for selecting oligonucleotides for biased polynucleotide amplification is described. Related probes, methods and systems are also described.

Abstract: A system and method for improving the processing of communications signals received in the presence of narrowband interference signals. The received communications signals are time sampled and transformed into a series of spectral terms in the frequency domain that are then evaluated to identify narrowband interference signals. The identified narrowband interference terms can be calculated to a value that will optimize the corrupted spectral terms resulting from the communication, and an inverse transformation can be used to generate a time domain signal that is free from interference.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same.

Abstract: A system for monitoring temperature in a body, the system comprising at least one implantable device, wherein the implantable device(s) is operable to sense temperature in the body and to generate status signals based on the sensed temperature in the body. The system further comprising a system control unit for wirelessly communicating with the implantable device(s), and the system control unit comprising a signal receiver for receiving the status signals, and also a programmable controller for producing notification signals based on the received status signals. A notification unit can alternatively communicate with the system control unit or the implantable device(s) for disclosing the sensed body temperature based on the notification signals.

Abstract: An ambulatory medical device including a reservoir, a fluid transfer device operably connected to the reservoir, and a pressure regulator that has a valve seat and a valve element movable between a closed position where the valve element engages the valve seat and prevents fluid flow and an open position where the valve element is in spaced relation to the valve seat and does not prevent fluid flow. One of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is engaged by the other of the valve seat and the valve element when the valve element is in the closed position.

Abstract: Remote controls that are configured to prevent inadvertent signal transmission.

Abstract: Implantable infusion apparatus, systems and methods that involve the use of a sensor that is associated with the catheter outlet.

Abstract: A high voltage full wave rectifier circuit having complementary serially connected low voltage MOSFET stacks provides high voltage rectifier capability. The MOSFET stacks are coupled to a pair of cross coupled MOSFETs that provide a full wave rectified output voltage. The state of the MOSFETs in the MOSFET stacks is controlled by resistors coupled between the rectifier output and a time varying input signal. The resistance values of the resistors are selected to maintain operation of the stacked MOSFETs below their breakdown voltages. A pair of diodes is connected between ground and the MOSFET stacks. A plurality of diode connected MOSFETs are connected between the rectifier output and the resistors to establish bias voltages on the gates of the MOSFETs in the MOSFET stacks to control operation of the rectifier during input voltage cycles. A voltage doubler circuit is also described where low voltage MOSFETs are utilized in a novel configuration to provide high voltage doubling capability.

Abstract: The invention is a component assembly and method of hermetically bonding a ceramic part to a metal part by welding and brazing a component assembly comprised of metal parts, a ceramic part, and an intermediate metal ferrule. The ceramic part is preferably a hollow tube of partially-stabilized zirconia that is brazed to an alignment ferrule that is preferably titanium or a titanium alloy, such as Ti-6Al-4V. On one end the component assembly is brazed to an end cap for closure. On the other end the alignment ferrule is preferably brazed to a ring that is preferably comprised of a noble metal, such as platinum, iridium, or alloys of platinum and iridium. The ring is then laser welded to an eyelet that is preferably comprised of a noble metal.

Abstract: An embodiment of the invention includes a biocompatible stiffness enhanced pliable electrically conductive filament configured for contact with living tissue and electrical communication with such tissue. The pliability of the filament allows the distal end of the filament to remain at the original site of penetration into the tissue despite the movement of the tissue relative to its surrounding environment. To temporarily stiffen the filament, a soluble stiffness enhancing coating is disposed over the filament. The coating may be in the form of a liquid which dries to a solid state after being applied to the filament and renders the filament sufficiently rigid such that under appropriate force, the filament is capable of penetrating into dense tissue. Once in place the stiffness enhancing coating dissolves due to contact with body fluids, the filament, in the absence of such coating, returns to its initial pliability.

Abstract: An implantable medication delivery device that is highly space efficient and can reliably and safely deliver controlled medication doses to a target site. The system includes a variable volume medication reservoir that is exposed to an ambient pressure equal to the ambient pressure at a system outlet port. A pump/valve subassembly is provided to draw medication from the reservoir and force a medication dose along a fluid transfer passageway to the outlet port. The pump/valve subassembly incorporates a safety mechanism, e.g., a balanced valve, which normally blocks medication flow to the outlet port and opens only in response to a pump induced unbalancing force. A protective shell is also disclosed for protecting the ambient reservoir.

Abstract: Fluid transfer devices for use in, for example, ambulatory infusion devices and infusions devices including fluid transfer devices.

Abstract: An apparatus and method is related to providing sensing functions that are similar to “human touch” when located in a prosthetic device such as a BION microstimulator that is implanted in a patient. The apparatus includes a power circuit, a communication circuit, and a sensor circuit. The power circuit provides power to the communication circuit and the sensor circuit. The sensor cooperates with the communication circuit, which communicates to the brain. The sensor uses various techniques to detect changes in the environment for the surrounding tissue using criteria such as reflectivity, impedance, conductivity, return signal spectrum, return signal rate, and return signal phase to name a few. For example, the impedance observed by the sensor changes when: the skin tissue is deformed around the sensor, or when the skin is surrounded by water. The sensory information is interpreted by the brain as an analog of touch or feel.

Abstract: Remote controls, including a communication device, a button or other communication device actuator and a movable structure that allows actuation of the actuator in one position and prevents actuation of the actuator in another position to prevent inadvertent signal transmission.

Abstract: An electronics filter circuit includes an electromechanical resonator that is mounted directly to the surface of a silicon integrated circuit, rather than being a surface mounted or leaded filter can on a circuit board. This filter circuit allows the integrated circuit electronic package to be significantly smaller than a conventional electromechanical resonator package. The electromechanical resonator may be protected during processing and during use with a protective cover that is made of a material such as titanium. The protective cover is attached to the integrated circuit chip.

Abstract: A high voltage current source and a voltage expander implemented in a low voltage semiconductor process. The voltage expander extends the operating voltage range of a stack of transistors to multiple times a supply voltage Vdd at the output node of the stack without exceeding the breakdown voltage of any of the transistors in the stack. The voltage expander uses a diode and a voltage divider to detect the output node voltage changes and generates a plurality of voltages that control the gate voltages for the stack of transistors. A high voltage wide swing current source utilizes a transistor to set the output current and the voltage expander to extend the output voltage range of the current setting transistor. An additional transistor and another current source ensure that the output current is constant throughout the entire output voltage range between about 0V and multiple times the supply voltage Vdd.

Abstract: Implantable infusion apparatus, systems and methods that involve the use of a sensor that is associated with the catheter outlet.

Abstract: Fluid transfer devices for use in, for example, ambulatory infusion devices, and infusions devices including such fluid transfer devices. The fluid transfer devices may include an external housing tube, an internal housing tube that has a piston lumen with a pump chamber, an outer surface, and a bypass aperture with an inlet associated with the pump chamber and an outlet adjacent to the outer surface, a bypass channel in fluid communication with the bypass aperture outlet, a resilient valve member associated with the bypass aperture outlet, and a piston carried within the piston lumen.

Abstract: Systems and methods for power and bidirectional data transmission using a plurality of wires. A multiphase digital signal is downlinked from a main unit to a remote unit over the plurality of wires and is converted to a DC power signal used to power the remote unit. Uplink data is sent from the remote to the main over one selected wire during a predetermined time period for an uplink transmission by amplitude modulating the received digital signal at the remote. During an uplink, the output impedance of the line driver in the main unit connected to the wire selected for the uplink is increased to allow for the uplink amplitude modulation. The modulated signal is maintained within the noise margins of the digital circuits in the main and remote units.

Abstract: A device configured for implantation beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, containing a power source for powering electronic circuitry within. A placement structure is shown for facilitating placement of the implantable device proximate to neural/muscular tissue.