Patents Assigned to Alios BioPharma, Inc.
  • Methods of preparing substituted nucleoside analogs
    Patent number: 10519185
    Abstract: Disclosed herein are methods of preparing a nucleoside analog, Compound (I): or a pharmaceutically acceptable salt thereof, which is useful in treating diseases and/or conditions such as viral infections, and intermediates thereof.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 31, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10485815
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: November 26, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Guangyi Wang, David Bernard Smith, Leonid Beigelman, Jerome Deval, Marija Prhavc
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10464965
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: November 5, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Leonid Beigelman, Guangyi Wang, David Bernard Smith, Jerome Deval, Marija Prhavc
  • AZA-PYRIDONE COMPOUNDS AND USES THEREOF
    Publication number: 20190314373
    Abstract: Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
    Type: Application
    Filed: March 1, 2019
    Publication date: October 17, 2019
    Applicant: Alios BioPharma, Inc.
    Inventors: Robert Than HENDRICKS, Leonid BEIGELMAN, David Bernard SMITH, Antitsa Dimitrova STOYCHEVA
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10421771
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: September 24, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Leonid Beigelman, Guangyi Wang, David Bernard Smith, Jerome Deval, Marija Prhavc
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10420788
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: September 24, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Guangyi Wang, David Bernard Smith, Leonid Beigelman, Jerome Deval, Marija Prhavc
  • ANTIVIRAL COMPOUNDS
    Publication number: 20190263754
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Application
    Filed: October 19, 2018
    Publication date: August 29, 2019
    Applicant: Alios BioPharma, Inc.
    Inventors: Guangyi WANG, Leonid BEIGELMAN, Anh TRUONG, Carmela NAPOLITANO, Daniele ANDREOTTI, Haiying HE, Karin Ann STEIN
  • Pyridazinone compounds and uses thereof
    Patent number: 10364226
    Abstract: Disclosed herein are pyridazinone compounds, pharmaceutical compositions that include one or more pyridazinone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with a pyridazinone compounds. Examples of an orthomyxovirus viral infection includes an influenza infection.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: July 30, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Leonid Beigelman, Robert Than Hendricks, Antitsa Dimitrova Stoycheva, Jerome Deval, Sarah Katherine Stevens
  • Antiviral compounds
    Patent number: 10358453
    Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: July 23, 2019
    Assignee: Alios BioPharma, Inc.
    Inventors: Guangyi Wang, Leonid Beigelman, Anh Truong, Karin Ann Stein
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10307439
    Abstract: Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: June 4, 2019
    Assignee: Alios Biopharma, Inc.
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Julian Alexander Symons, David Bernard Smith
  • Aza-pyridone compounds and uses thereof
    Patent number: 10251882
    Abstract: Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 9, 2019
    Assignee: Alios BioPharma, Inc.
    Inventors: Robert Than Hendricks, Leonid Beigelman, David Bernard Smith, Antitsa Dimitrova Stoycheva
  • Aza-pyridone compounds and uses thereof
    Patent number: 10208045
    Abstract: Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compound. Examples of an orthomyxovirus viral infection include an influenza infection.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: February 19, 2019
    Assignee: Alios BioPharma, Inc.
    Inventors: Robert Than Hendricks, Leonid Beigelman, David Bernard Smith, Antitsa Dimitrova Stoycheva
  • Method of preparing AZA-pyridone compounds
    Patent number: 10183945
    Abstract: Disclosed herein are methods for obtaining aza-pyridone compounds, which can be useful for ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: January 22, 2019
    Assignee: ALIOS BIOPHARMA, INC.
    Inventors: Michael Hunter Welch, Leonid Beigelman, Robert Than Hendricks, Andras Horvath, Gareth Brown, Prasad Ganji, Stefan Mix
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10144755
    Abstract: Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: December 4, 2018
    Assignee: Alios BioPharma, Inc.
    Inventors: Leonid Beigelman, Guangyi Wang, David Bernard Smith
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10112966
    Abstract: Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 30, 2018
    Assignee: Alios BioPharma, Inc.
    Inventors: Leonid Beigelman, Guangyi Wang, David Bernard Smith
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 10052342
    Abstract: Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: August 21, 2018
    Assignee: Alios BioPharma, Inc.
    Inventors: Lawrence M. Blatt, Leonid Beigelman, Natalia Dyatkina, Julian Alexander Symons, David Bernard Smith
  • OLIGONUCLEOTIDE TARGETING STRATEGY FOR cccDNA
    Publication number: 20180179542
    Abstract: The present disclosure provides oligonucleotide compositions that target the covalently closed circular (ccc) DNA of hepatitis B virus (HBV). Also disclosed herein are methods for treating a subject diagnosed with, or suspected of having an HBV infection and/or an HBV-associated disorder, e.g., chronic hepatitis B infection, liver failure or cirrhosis and hepatocellular carcinoma.
    Type: Application
    Filed: November 13, 2017
    Publication date: June 28, 2018
    Applicant: Alios Biopharma, Inc.
    Inventors: Sergei Gryaznov, Megan Fitzgerald, Antitsa Dimitrova Stoycheva, Jin Hong
  • MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20180135054
    Abstract: Modified oligonucleotides comprising modifications at the 2? and/or 3? positions(s) along with methods of making and use, e.g., against HBV are disclosed.
    Type: Application
    Filed: September 14, 2017
    Publication date: May 17, 2018
    Applicant: Alios Biopharma, Inc.
    Inventors: Sergei GRYAZNOV, Leonid Beigelman, Antitsa Dimitrova Stoycheva, Saul Martinez Montero, Jin Hong
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 9932363
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: April 3, 2018
    Assignee: Alios BioPharma, Inc.
    Inventors: Natalia Dyatkina, Guangyi Wang, Leonid Beigelman, Vivek Kumar Rajwanshi
  • Methods of preparing substituted nucleoside analogs
    Patent number: 9908914
    Abstract: Disclosed herein are methods of preparing a nucleoside analog (I) by a reaction that includes an intermediate (GG): Nucleoside analog (I) is useful in treating diseases and/or conditions such as viral infections.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: March 6, 2018
    Assignee: Alios BioPharma, Inc.
    Inventors: Vladimir Serebryany, Jyanwei Liu, Leonid Beigelman