Patents Assigned to ALK-Abelló A/S
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Patent number: 11020527Abstract: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.Type: GrantFiled: July 11, 2016Date of Patent: June 1, 2021Assignee: ALK-ABELLÓ A/SInventor: Jens Mikkelsen
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Patent number: 10874736Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).Type: GrantFiled: January 8, 2016Date of Patent: December 29, 2020Assignee: ALK-ABELLO A/SInventors: Heather Michelle Webster, Jason Daniel Frey, Trena Larissa Repp, Craig T. Grass, David Rowles, Gary Smith, Domingo Barber Hernandez, Fernando Juan Vidales, Carmen Arteaga Vázquez, Juan Carlos Moreno Segura, Maria José Chamorro Salillas
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Patent number: 10842866Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).Type: GrantFiled: December 20, 2019Date of Patent: November 24, 2020Assignee: ALK-ABELLÓ A/SInventors: Heather Michelle Webster, Jason Daniel Frey, Trena Larissa Repp, Craig T. Grass, David Rowles, Gary Smith, Domingo Barber Hernandez, Fernando Juan Vidales, Carmen Arteaga Vázquez, Juan Carlos Moreno Segura, Maria José Chamorro Salillas
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Publication number: 20200123213Abstract: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.Type: ApplicationFiled: December 20, 2019Publication date: April 23, 2020Applicants: ALK-ABELLÓ A/S, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGYInventors: Bjoern Peters, Gitte Lund, Lars Harder Christensen, Thomas Stranzl, Alessandro Sette
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Publication number: 20200108138Abstract: The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).Type: ApplicationFiled: December 20, 2019Publication date: April 9, 2020Applicant: ALK-Abelló A/SInventors: Heather Michelle Webster, Jason Daniel Frey, Trena Larissa Repp, Craig T. Grass, David Rowles, Gary Smith, Domingo Barber Hernandez, Fernando Juan Vidales, Carmen Arteaga Vázquez, Juan Carlos Moreno Segura, Maria José Chamorro Salillas
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Patent number: 10471008Abstract: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.Type: GrantFiled: September 8, 2017Date of Patent: November 12, 2019Assignee: ALK-Abelló A/SInventors: Henrik Hugo Jacobi, Annette Rømmelmayer Lundegaard, Christian Gauguin Houghton, Jan Søndergaard-Andersen, Stig Asmul-Olsen, Lise Lund Mærkedahl
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Publication number: 20190202875Abstract: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.Type: ApplicationFiled: May 29, 2017Publication date: July 4, 2019Applicants: ALK-ABELLÓ A/S, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGYInventors: Bjoern Peters, Gitte Lund, Lars Harder Christensen, Thomas Stranzl, Alessandro Sette
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Patent number: 10080719Abstract: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.Type: GrantFiled: July 6, 2016Date of Patent: September 25, 2018Assignee: ALK-ABELLÓ A/SInventors: Henrik Hugo Jacobi, Annette Roemmelmayer Lundegaard, Christian Gauguin Houghton, Stig Aasmul-Olsen, Lise Lund Maerkedahl, Jan Sondergaard Andersen
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Patent number: 10059751Abstract: The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of a house dust mite allergen, e.g. the allergens Der p 1, Der f 1, Der p 2 and/or Der f 2. Such peptides comprise at least one T cell epitope and a significant high number of patients in a worldwide population will have HLA alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by a dust mite.Type: GrantFiled: December 23, 2014Date of Patent: August 28, 2018Assignees: ALK-ABELLÓ A/S, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOGYInventors: Claus Lundegaard, Lars Harder Christensen, Peter Adler Wurtzen, Alessandro Sette, John Sidney, Gitte Lund, Peter Sejer Andersen
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Publication number: 20180207228Abstract: The invention relates to combinations of peptides derived from a portion of an amino sequence of a grass pollen allergen, e.g. the allergens Phl p 1, Phl p 2, Phl p 3, Phl p 4 and/or Phl p 5, or a peptide variant thereof. Such peptides comprise at least one T cell epitope mid a high number of patients in a worldwide population will have HLA Class II alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by grass pollen species.Type: ApplicationFiled: July 1, 2016Publication date: July 26, 2018Applicants: ALK-Abelló A/SInventors: Claus Lundegaard, Shashank Gupta, Bjoern Peters, Susanne Sønderkær, Jens Brimnes, Peter Adler Würtzen, Helene Henmar, Thomas Christian Mygind, Lise Lund Mærkedahl
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Patent number: 10023900Abstract: The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard peptide(s) having a sequence of amino acids which is identical with, and optionally unique for, a sequence to be found in the allergen to be quantified and optionally labelling said allergen calibration standard peptide(s), b) degrading the allergen sample to obtain a mixture of peptides, and optionally labelling said peptides with one or more labelling agent(s), wherein at least the peptides in the degraded allergen sample or the calibration standard peptides are labelled, and if both the peptides in the degraded allergen sample and the allergen calibration standard peptide(s) are labelled, the labelling agent(s) used for labelling the allergen calibration standard peptide(s) are different from the labelling agent(s) used for labelling the peptides of the degraded allergen sample, c) quantifying the absolute amountType: GrantFiled: March 5, 2014Date of Patent: July 17, 2018Assignee: ALK-ABELLO A/SInventor: Ulla Seppälä
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Publication number: 20180185582Abstract: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.Type: ApplicationFiled: July 11, 2016Publication date: July 5, 2018Applicant: ALK-Abelló A/SInventor: Jens MIKKELSEN
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Publication number: 20170367970Abstract: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.Type: ApplicationFiled: September 8, 2017Publication date: December 28, 2017Applicant: ALK-Abelló A/SInventors: Henrik Hugo Jacobi, Annette Rømmelmayer Lundegaard, Christian Gauguin Houghton, Jan Søndergaard Andersen, Stig Asmul-Olsen, Lise Lund Mærkedahl
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Patent number: 9657070Abstract: Dander from the domestic cat (Felis domesticus) is one of the most common causes of IgE mediated allergy. The present invention relates to a recombinant folded Fel d 1 with molecular and biological properties similar to the natural counterpart and specifically a synthetic gene coding for a direct fusion of Fel d 1 chain 2 N-terminally to chain 1. E coli expression resulted in a non-covalently associated homodimer with an apparent molecular weight of 30 kDa defined by size exclusion chromatography, each 19177 Da subunit displayed a disulfide pattern identical to that found in the natural Fel d 1, and having identical fold of natural and recombinant Fel d 1. The, recombinant Fel d 1 provides for diagnosis and allergen specific immunotherapy of cat allergy.Type: GrantFiled: February 20, 2013Date of Patent: May 23, 2017Assignee: ALK-ABELLO A/SInventors: Hans Gronlund, Marianne van Hage
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Publication number: 20170087231Abstract: A composition comprising at least one first allergen, which is a respiratory allergen belonging to a first biological source material group, for use in prophylactic treatment of allergy to at least one second allergen, which is selected from the group consisting of a respiratory and a venomous allergen belonging to a second biological source material group and a food allergen of a food composition, in a subject, wherein the subject has not developed any clinical symptoms of allergy to the first allergen and to the second allergen, and wherein the first and second biological source material groups are not the same.Type: ApplicationFiled: June 4, 2015Publication date: March 30, 2017Applicant: ALK-ABELLÓ A/SInventors: Syed Hasan Arshad, Graham Colin Roberts, Bente Riis, Dorte Ellen Schrøder
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Publication number: 20160324767Abstract: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.Type: ApplicationFiled: July 6, 2016Publication date: November 10, 2016Applicants: ALK-Abello A/S, R.P. Scherer Technologies, LLCInventors: Henrik Hugo Jacobi, Annette Roemmelmayer Lundegaard, Christian Gauguin Houghton, Stig Aasmul-Olsen, Lise Lund Maerkedahl, Jan Sondergaard Andersen, Kerry Mallindine, Owen James Murray, Susan Gerrard Banbury, Desmond Yik Teng Wong, Lisa Marie Garrett, Michael Hall
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Publication number: 20160287696Abstract: The invention relates to pan pollen immunogens such as polypeptides, proteins and peptides, and methods and uses of such immunogens for modulating or relieving an immune response in a subject. For example, the immunogens can be used for treating a subject for an allergic immune response or inducing or promoting immunological tolerance to the immunogen or a pollen allergen in a subject.Type: ApplicationFiled: November 20, 2014Publication date: October 6, 2016Applicants: La Jolla Institute For Allergy And Immunology, ALK-Abelló A/SInventors: Bjoern Peters, Alessandro Sette, Jason Greenbaum, Ilka Hoof, Lars Harder Christensen
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Publication number: 20160251403Abstract: The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of CM a house dust mite allergen, e.g. the allergens Der p 1, Der f 1, Der p 2 and/or Der f 2. Such peptides comprise at least one T cell epitope and a significant high number of patients in a worldwide population will have HLA alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by a dust mite.Type: ApplicationFiled: December 23, 2014Publication date: September 1, 2016Applicants: ALK-ABELLO A/S, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGYInventors: Claus Lundegaard, Lars Harder Christensen, Peter Adler Wurtzen, Alessandro Sette, John Sidney, Gitte Lund
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Patent number: 9415015Abstract: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.Type: GrantFiled: April 4, 2008Date of Patent: August 16, 2016Assignees: ALK-Abello A/S, R.P. Scherer Technologies, LLCInventors: Henrik Hugo Jacobi, Annette Roemmelmayer Lundegaard, Christian Gauguin Houghton, Stig Aasmul-Olsen, Lise Lund Maerkedahl, Jan Sondergaard Andersen, Kerry Mallindine, Owen James Murray, Susan Gerrard Banbury, Desmond Yik Teng Wong, Lisa Marie Garrett, Michael Hall
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Patent number: 9408805Abstract: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.Type: GrantFiled: May 27, 2014Date of Patent: August 9, 2016Assignees: ALK-Abello A/S, R.P. Scherer Technologies, LLCInventors: Henrik Hugo Jacobi, Annette Roemmelmayer Lundegaard, Christian Gauguin Houghton, Stig Aasmul-Olsen, Lise Lund Maerkedahl, Jan Sondergaard Andersen, Kerry Mallindine, Owen James Murray, Susan Gerrard Banbury, Desmond Yik Teng Wong, Lisa Marie Garrett, Michael Hall