Patents Assigned to Alkermes Controlled Therapeutics Inc. II
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Patent number: 7118763Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.Type: GrantFiled: August 18, 2004Date of Patent: October 10, 2006Assignees: Alkermes Controlled Therapeutics, Inc. II, Janssen PharmaceuticaInventors: Jean Mesens, Michael E. Rickey, Thomas J. Atkins
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Publication number: 20060182810Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.Type: ApplicationFiled: March 2, 2006Publication date: August 17, 2006Applicants: Janssen Pharmaceutica, N.V., Alkermes Controlled Therapeutics Inc. IIInventors: Jean Mesens, Michael Rickey, Thomas Atkins
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Patent number: 7074883Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.Type: GrantFiled: December 1, 2003Date of Patent: July 11, 2006Assignee: Alkermes Controlled Therapeutics, Inc. IIInventor: Chiem V. Pham
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Publication number: 20060099271Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.Type: ApplicationFiled: December 21, 2005Publication date: May 11, 2006Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Michael Rickey, J. Michael Ramstack, Rajesh Kumar
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Publication number: 20050276859Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.Type: ApplicationFiled: May 16, 2005Publication date: December 15, 2005Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Michael Rickey, J. Ramstack, Danny Lewis
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Publication number: 20050266091Abstract: Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.Type: ApplicationFiled: June 22, 2005Publication date: December 1, 2005Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Shawn Lyons, Steven Wright
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Publication number: 20050196457Abstract: Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.Type: ApplicationFiled: January 26, 2005Publication date: September 8, 2005Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Shawn Lyons, Steven Wright
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Patent number: 6939033Abstract: Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.Type: GrantFiled: December 9, 2003Date of Patent: September 6, 2005Assignee: Alkermes Controlled Therapeutics, Inc. IIInventors: Shawn L. Lyons, Steven G. Wright
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Patent number: 6884372Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.Type: GrantFiled: April 12, 2004Date of Patent: April 26, 2005Assignee: Alkermes Controlled Therapeutics, Inc. IIInventor: J. Michael Ramstack
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Publication number: 20050079224Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.Type: ApplicationFiled: October 4, 2004Publication date: April 14, 2005Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Michael Rickey, J. Ramstack, Rajesh Kumar
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Patent number: 6861016Abstract: Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.Type: GrantFiled: November 17, 2003Date of Patent: March 1, 2005Assignee: Alkermes Controlled Therapeutics Inc. IIInventors: Shawn L. Lyons, Steven G. Wright
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Publication number: 20050025828Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.Type: ApplicationFiled: August 18, 2004Publication date: February 3, 2005Applicants: Alkermes Controlled Therapeutics Inc. II, Janssen PharmaceuticaInventors: Jean Mesens, Michael Rickey, Thomas Atkins
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Publication number: 20050020734Abstract: The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with ?-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(?-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(?-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.Type: ApplicationFiled: August 23, 2004Publication date: January 27, 2005Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Firouz Asgarzadeh, Henry Costantino
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Patent number: 6830737Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.Type: GrantFiled: September 6, 2002Date of Patent: December 14, 2004Assignee: Alkermes Controlled Therapeutics Inc. IIInventor: J. Michael Ramstack
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Patent number: 6824822Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.Type: GrantFiled: August 31, 2001Date of Patent: November 30, 2004Assignee: Alkermes Controlled Therapeutics Inc. IIInventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
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Publication number: 20040197469Abstract: Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.Type: ApplicationFiled: November 17, 2003Publication date: October 7, 2004Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Shawn L. Lyons, Steven G. Wright
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Publication number: 20040197417Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is_ prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.Type: ApplicationFiled: July 25, 2003Publication date: October 7, 2004Applicant: Alkermes Controlled Therapeutics Inc. IIInventors: Michael E. Rickey, J. Michael Ramstack, Danny H. Lewis
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Patent number: 6800663Abstract: The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with &agr;-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(&agr;-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(&agr;-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.Type: GrantFiled: October 18, 2002Date of Patent: October 5, 2004Assignee: Alkermes Controlled Therapeutics Inc. II,Inventors: Firouz Asgarzadeh, Henry R. Costantino
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Publication number: 20040191324Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.Type: ApplicationFiled: April 12, 2004Publication date: September 30, 2004Applicant: Alkermes Controlled Therapeutics Inc. IIInventor: J. Michael Ramstack
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Publication number: 20040108609Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.Type: ApplicationFiled: December 1, 2003Publication date: June 10, 2004Applicant: Alkermes Controlled Therapeutics Inc. IIInventor: Chiem V. Pham