Patents Assigned to Alkermes Science One Limited
  • Controlled release compositions comprising a combination of isosorbide dinitrate and hydralazine hydrochloride
    Patent number: 8992973
    Abstract: The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: March 31, 2015
    Assignee: Alkermes Science One Limited
    Inventors: Gurvinder Singh Rekhi, Richard Sidwell, Sharon Hamm