Patents Assigned to Allele Biotechnology & Pharmaceuticals, Inc.
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Patent number: 10842728Abstract: The present disclosure relates to methods and compositions comprising naturally occurring light absorbing molecules for preventing damages from light exposure. Specific embodiments of this disclosure include fluorescent proteins from Brachiostoma lanceolatum.Type: GrantFiled: August 21, 2017Date of Patent: November 24, 2020Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Patent number: 10435711Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: GrantFiled: November 5, 2018Date of Patent: October 8, 2019Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Patent number: 10221221Abstract: The present disclosure provides isolated nucleic acid sequences encoding a monomeric green/yellow fluorescent proteins, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present invention further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present invention provides a monomeric green/yellow fluorescent protein encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the green/yellow fluorescent protein.Type: GrantFiled: July 24, 2013Date of Patent: March 5, 2019Assignee: ALLELE BIOTECHNOLOGY & PHARMACEUTICALS, INCInventors: Nathan C. Shaner, Gerard G. Lambert, Yuhui Ni, Jiwu Wang
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Publication number: 20190017019Abstract: A novel method of inducing neural progenitor cells, oligodendrocyte progenitor cells, oligodendrocytes from human iPSCs at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered transcription factors at multiple critical differentiation decision points along a pluripotent to ectoderm, neural ectoderm to NPCs to OPCs to oligodendrocytes pathway in a previously unknown manner.Type: ApplicationFiled: July 13, 2018Publication date: January 17, 2019Applicant: Allele Biotechnology and Pharmaceuticals, Inc.Inventors: Jiwu WANG, Yuhui NI, Yuanyuan ZHAO
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Patent number: 10155929Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: GrantFiled: May 13, 2013Date of Patent: December 18, 2018Assignee: ALLELE BIOTECHNOLOGY & PHARMACEUTICALS, INC.Inventors: Jiwu Wang, Luigi Warren, Yuhui Ni
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Patent number: 10119150Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: GrantFiled: May 30, 2014Date of Patent: November 6, 2018Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Patent number: 9737472Abstract: The present disclosure relates to methods and compositions comprising naturally occurring light absorbing molecules for preventing damages from light exposure. Specific embodiments of this disclosure include fluorescent proteins from Brachiostoma lanceolatum.Type: GrantFiled: December 7, 2015Date of Patent: August 22, 2017Assignee: ALLELE BIOTECHNOLOGY & PHARMACEUTICALS, INC.Inventor: Jiwu Wang
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Patent number: 9205284Abstract: The present disclosure relates to methods and compositions comprising naturally occurring light absorbing molecules for preventing damages from light exposure. Specific embodiments of this disclosure include fluorescent proteins from Brachiostoma lanceolatum.Type: GrantFiled: August 9, 2011Date of Patent: December 8, 2015Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Patent number: 9145447Abstract: The present disclosure provides an isolated nucleic acid sequence encoding a monomeric photoconvertible fluorescent protein, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present disclosure further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present provides a monomeric photoconvertible fluorescent protein encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the photoconvertible fluorescent protein.Type: GrantFiled: December 3, 2010Date of Patent: September 29, 2015Assignees: Allele Biotechnology & Pharmaceuticals, Inc., University of Alberta, TEC EdmontonInventors: Jiwu Wang, Robert Earl Campbell, Hiofan Hoi, Nathan Christopher Shaner
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Publication number: 20140349401Abstract: The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.Type: ApplicationFiled: May 30, 2014Publication date: November 27, 2014Applicant: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu WANG
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Patent number: 7625750Abstract: DNA compositions that mediate gene silencing via RNA interference are provided. The DNA compositions include an RNA polymerase III promoter, which drives expression of a nucleotide sequence encoding an intermediate small interfering RNA molecule, and RNA polymerase III terminator.Type: GrantFiled: December 26, 2002Date of Patent: December 1, 2009Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Patent number: 7422896Abstract: DNA compositions that mediate gene silencing via RNA interference are provided. The DNA compositions include an RNA polymerase III promoter, which drives expression of a nucleotide sequence encoding an intermediate small interfering RNA molecule, and RNA polymerase III terminator.Type: GrantFiled: August 12, 2002Date of Patent: September 9, 2008Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Patent number: 7294504Abstract: DNA compositions that mediate gene silencing via RNA interference are provided. Also provided are methods of using such compositions to silence gene expression in a cell.Type: GrantFiled: July 23, 2002Date of Patent: November 13, 2007Assignee: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang
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Publication number: 20050042603Abstract: Compositions that increase the efficiency of nucleic acid transfection of cells are provided, including peptide transfection reagents and fusion proteins containing the peptides. Also provided are methods of using the peptide transfection reagents and fusion proteins to transfect cells.Type: ApplicationFiled: June 29, 2004Publication date: February 24, 2005Applicant: Allele Biotechnology & Pharmaceuticals, Inc.Inventor: Jiwu Wang