Patents Assigned to Allergan, Inc.
  • Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
    Patent number: 9855232
    Abstract: The invention provides new crystalline forms of 7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid. This compound is commonly referred to as “bimatoprost acid.” The novel crystalline forms are designated forms I, II, and III. The invention crystalline forms are useful for solid ocular implant formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension. In addition, invention crystalline forms are useful for solid or semisolid dosage formulations used to treat ocular hypertension.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: January 2, 2018
    Assignee: ALLERGAN, INC.
    Inventors: Ke Wu, Shaoxin Feng, Thomas K. Karami, Scott W. Smith
  • Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases
    Patent number: 9850264
    Abstract: The present invention relates to a method for treating ocular inflammatory diseases in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: December 26, 2017
    Assignee: Allergan, Inc.
    Inventors: Richard L. Beard, John E. Donello, Veena Viswanath
  • Dual plane breast implant
    Patent number: 9848972
    Abstract: A soft breast prosthesis is provided, the prosthesis having a surface configuration advantageous for dual plane placement of the prosthesis in a breast.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: December 26, 2017
    Assignee: Allergan, Inc.
    Inventors: Dennis Van Epps, David Schuessler
  • Methods of treating ? adrenergic mediated conditions
    Patent number: 9849113
    Abstract: Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ?-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, acute, neuropathic and chronic.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: December 26, 2017
    Assignee: Allergan, Inc.
    Inventors: Daniel W. Gil, John E. Donello, Wenkui K. Fang, Phong X. Nguyen, Ken Chow, Todd M. Heidelbaugh, Dario G. Gomez, Michael E. Garst, Santosh C. Sinha
  • Degradable clostridial toxins
    Patent number: 9850476
    Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: December 26, 2017
    Assignee: Allergan, Inc.
    Inventors: Lance E. Steward, Sanjiv Ghanshani, Ester Fernandez-Salas, Marcella A. Gilmore, Joseph Francis, Kei Roger Aoki
  • Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith
    Patent number: 9849140
    Abstract: Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: December 26, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Kevin S. Warner, Kristin B. Prinn, Chetan P. Pujara, Pramod Sarpotdar, John T. Trogden, Adnan K. Salameh, Guang Wei Lu
  • Prevention and treatment of ocular side effects with a cyclosporin
    Patent number: 9839667
    Abstract: The present disclosure relates to methods of treatment or prevention of ocular conditions caused by treatment with certain therapeutically active agents. The methods can include administering a cyclosporine, an analog or derivative thereof, or a combination thereof to an eye of a mammal suffering from an ocular condition cased by treatment with certain therapeutically active agents, which can include a chemotherapy agent or an antiviral agent.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: December 12, 2017
    Assignee: Allergan, Inc.
    Inventors: Gregg Feinerman, Neil Barth, Rhett Schiffman, Pamela S. Barnett
  • Suture line administration technique using botulinum toxins
    Patent number: 9827297
    Abstract: The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a botulinum neurotoxin, to a patient suffering from a headache pain, where the location of administration of the botulinum toxin is based upon at least one suture line of the patient's skull.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 28, 2017
    Assignee: Allergan, Inc.
    Inventor: Andrew M. Blumenfeld
  • 1-aryl-1-hydroxy-2,3-diamino-propyl amines, 1-heteroaryl-1-hydroxy-2,3-diamino-propyl amines and related compounds having analgesic and/or immuno stimulant activity
    Patent number: 9828349
    Abstract: Compounds of the formula where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 28, 2017
    Assignees: EXONHIT THERAPEUTICS SA, ALLERGAN, INC.
    Inventors: Bertrand Leblond, Eric Beusoleil, Thierry Taverne, John E. Donello
  • Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
    Patent number: 9821086
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: November 21, 2017
    Assignee: Allergan, Inc.
    Inventors: Xiaojie Yu, Nicholas J. Manesis, Jacob Pollock
  • Method of treating conditions with kinase inhibitors
    Patent number: 9820989
    Abstract: The present invention relates to a method of treating ophthalmic diseases and conditions, e.g. diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, etc., in a subject comprising administering to said subject a therapeutically effective amount of at least one compound of formula I or a prodrug, pharmaceutically acceptable salt, racemic mixtures or enantiomers of said compound. The compounds of formula I are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 21, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Clarence E. Hull, III, Thomas C. Malone
  • Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues
    Patent number: 9820995
    Abstract: Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component that includes an Glucocorticoid Derivative which, upon delivery to the posterior segment of a mammalian eye, does not significantly diffuse to the anterior segment of said eye. Methods of making and using the present materials are also described.
    Type: Grant
    Filed: February 15, 2016
    Date of Patent: November 21, 2017
    Assignee: Allergan, Inc.
    Inventors: Jeffrey L. Edelman, Kelly M. Harrison
  • Artificial tears and therapeutic uses
    Patent number: 9821020
    Abstract: The present invention provides ophthalmic compositions, e.g. artificial tears, suitable for treating dry eye syndrome in a human or other mammal suffering there from, e.g. a dog or cat, which comprise a mixture of castor oil with another oil, e.g. a food oil, e.g. olive oil, sesame oil, corn oil etc.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: November 21, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Anuradha V. Gore, Robert S. Jordan, Kevin Krock, Chetan Pujara
  • Soft filled prosthesis shell with variable texture
    Patent number: 9808338
    Abstract: A soft prosthetic implant, such as a silicone breast implant, is provided. The implant has a variety of different surfaces, for example, different textures, located on different areas of the outer surface of the implant.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: November 7, 2017
    Assignee: Allergan, Inc.
    Inventors: David Schuessler, Dennis Van Epps
  • Compositions and methods for lowering intraocular pressure
    Patent number: 9801891
    Abstract: Disclosed herein are compositions for lowering intraocular pressure (IOP) of an eye comprising a combination IOP-lowering agents bimatoprost, brimonidine, and timolol. Further disclosed are methods for reducing IOP in the eye of a subject.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: October 31, 2017
    Assignee: ALLERGAN, INC.
    Inventor: Chetan P. Pujara
  • Stabilized oxymetazoline formulations and their uses
    Patent number: 9801857
    Abstract: The present invention provides stabilized cream formulations of oxymetazoline and uses thereof. The present invention also provides a method of treating facial erythema associated with rosacea in a patient in need of such treatment, comprising topically administering once or twice daily to the site of erythema on the face of the patient a pharmaceutical composition comprising 0.5%, 1.0% or 1.5% oxymetazoline or a pharmaceutically acceptable salt thereof as the sole active ingredient.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: October 31, 2017
    Assignee: Allergan, Inc.
    Inventors: Pramod Sarpotdar, Kevin Warner, Steven Zhang, Gurpreet Ahluwalia, Amy Kuang
  • Methods for fat reduction
    Patent number: 9795615
    Abstract: Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional hair growth.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 24, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Neil J. Poloso, Jenny Wang, David F. Woodward, Robert M. Burk
  • Substituted arylcyclopentenes as therapeutic agents
    Patent number: 9796696
    Abstract: Disclosed herein is a compound of the formula Therapeutic methods, compositions, and medicaments, related thereto are also disclosed.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: October 24, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Yariv Donde, Jeremiah H. Nguyen
  • Complement factor Bb antibodies
    Patent number: 9796776
    Abstract: The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement Factor Bb. Specifically, the disclosure is related to anti-complement Factor Bb antibodies.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: October 24, 2017
    Assignee: Allergan, Inc.
    Inventors: Yanbin Liang, Chen Li, Iris Lee, Victor M. Guzman
  • Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
    Patent number: 9795711
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: October 24, 2017
    Assignee: Allergan, Inc.
    Inventors: Xiaojie Yu, Nicholas J. Manesis, Jacob Pollock