Abstract: A specific liquid drop volume dispenser includes a container having side walls squeezable in a radial direction to a longitudinal axis of the container in order to dispense liquid drops therefrom at one end of the container. A rigid member is disposed in an operative relationship with the squeezable side walls, for limiting collapse of the squeezable side walls, in order to limit liquid drops dispensed from the container to a specific volume upon a single squeezing of the squeezable side walls, the squeezable side walls having sufficient resiliency to expand, after being squeezed to the rigid member, and draw therebetween, from a remainder of said container, a volume of liquid equal to the dispensed specific volume.

Abstract: A composition and method useful to quickly and effectively indicate whether a functional component such as catalase has been added to a clear solution such as a hydrogen peroxide solution involves compounding with the functional component an effective amount of vitamin B-12 such that when the compounded composition is added to the clear solution, the clear solution turns rose colored. By observing the rose color, the user can determine that the functional component has been added to the clear solution.

Abstract: Methods for producing intraocular lenses which can be non-surgically repositioned after being placed in an eye. Such methods include providing a lens blank at least a portion of which is a polymeric material having a glass transition temperature of at least about 40.degree. C., and forming from the lens blank an intraocular lens including an optic and a fixation member so that at least a portion of the fixation member is made of the polymeric material. The position of the optic in the eye can be changed by heating the fixation member to a temperature above the glass transition temperature.

Abstract: A multiple fluid dispensing device is provided which includes a plurality of liquid formulations with at least one formulation having a surface tension of less than a specific value. A tip is provided for dispensing of the liquid formulations in a dropwise fashion and an inner bottle, in communication with the tip, contains the liquid formulations in separate compartments, and forces the liquid formulations through the tip when compressed. The inner bottle is configured with a volume for preventing the liquid formulations from flowing out of the bottle through the tip without compression of the inner bottle. An outer bottle is provided and disposed around the inner bottle for compressing the inner bottle. The inner and outer bottles are sized for providing hydraulic advantage in compressing the inner bottle with the hydraulic advantage being manifested by the outer bottle having a greater inner surface area than an outer surface of the inner bottle.

Abstract: A syringe comprising a barrel having a longitudinal passage extending through the barrel and a plunger slidable in the passage of the barrel. The barrel has connector adjacent one end of the barrel for attaching a cannula to the barrel and a flange adjacent the other end of the barrel. An adapter having a passage extending through it is mounted on the barrel with the adapter engaging the flange of the barrel. The adapter extends radially beyond the flange to form finger pads.

Abstract: An IOL implantable in an eye including an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

Abstract: A method for reducing filtrate waste in a manufacturing process of a pharmaceutical product containing benzalkonium chloride as a preservative generally includes the steps of mixing the non-benzalkonium chloride components with benzalkonium chloride to formulate the product and thereafter sterilizing the product by passing same through a microfiltration membrane. In processes in which the product has a time dependent benzalkonium chloride content due to benzalkonium chloride adsorption on a microfiltration membrane, an amount of benzalkonium chloride wasted can be reduced by maintaining a selected temperature of the microfiltration membrane and the product therein.

Abstract: A method for disinfecting a contact lens, includes the step of contacting the lens with an effective amount of at least one D-enantiomeric anti-microbial agent for a period of time sufficient to disinfect the lens. A proteolytic enzyme can be used in conjunction with the anti-microbial agent for combined disinfection and cleaning. Contact lens disinfecting compositions comprising a D-enantiomeric anti-microbial agent are also provided.

Abstract: A reusable cartridge assembly for a phaco machine includes a first plate with a plurality of flow channels therein and a sealing gasket with a sheet for sealing against the first plate to prevent fluid from leaving the flow channels. In addition, a tube is provided, fixed to the sealing gasket and protruding therefrom, for enabling engagement between the tube and a pump head for circulation of fluid through flow channels. A second plate is provided for applying a sealing pressure between the sheet and the first plate. In addition, the sealing gasket may include a sensing element for determining pressure within the flow channels.

Abstract: An apparatus and method useful for disinfecting a contact lens are disclosed. The apparatus includes a color indicator element comprising an iodine component substantially irreversibly bonded to a solid material, preferably an anion exchange resin. The color indicator element is located in an oxidative disinfectant-containing liquid medium. This color indicator element provides a color indication of the presence of the oxidative disinfectant, e.g., hydrogen peroxide, in the liquid medium, and preferably a different color indication of the substantial absence of the oxidative disinfectant in the liquid medium.

Abstract: New intraocular lenses (IOLs) and methods for producing IOLs are disclosed. The present methods include a combination of steps which increase the pull strength between the fixation member of the IOL and the optic of the IOL without requiring sophisticated high frequency corona discharge activation or plasma activation of the fixation member. The fixation members are doubly coated with primer components and silicone polymeric material precursor compositions before being secured to the optics. In addition, the optic members employed in the present invention can be formed, for example, molded, without recesses to accommodate the fixation members. Thus, such recesses can be formed and provided with a quantity of the above-noted precursor composition after the optic members are produced. The doubly coated fixation members are then placed in the recesses and secured to the optic members. The present methods are straight forward, easy to practice and are cost effective in producing high quality IOLs.

Abstract: Compounds of the formula ##STR1## where W is (CH.sub.2).sub.n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen;m is an integer between 1 and 8;R.sub.1 is COOH or a pharmaceutically acceptable salt thereof, COOR.sub.4, CONR.sub.5 R.sub.6, CONR.sub.5 SO.sub.2 R.sub.7, CH.sub.2 OH, CH.sub.2 OR.sub.7, CH.sub.2 O--COR.sub.7, CH.sub.2 O--CONR.sub.5, R.sub.7, CH.sub.2 OCOOR.sub.7, CH.sub.2 NH.sub.2, CH.sub.2 NR.sub.5 R.sub.6, CH.sub.2 NR.sub.5 COR.sub.7, CHO, CH(OR.sub.8).sub.2, CHOR.sub.9 O, --COR.sub.10, CR.sub.10 (OR.sub.8).sub.2, or CR.sub.10 OR.sub.9 O, where R.sub.4 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.4 is phenyl or lower alkylphenyl, R.sub.5 and R.sub.6 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or phenyl or lower alkylphenyl, R.sub.7 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl, R.sub.8 is lower alkyl, and R.sub.

Abstract: A method for inducing prolonged pseudoaccommodation includes the instillation of an ophthalmic formulation into an eye for contracting the iris sphincter muscle, but not the ciliary muscle, in order to cause sphincter muscle contraction for a period of greater than about one hour per installation. The method further provides for the stabilization of an implanted intraocular lens immediately after surgery and for reducing glare following radial keratotomy.

Abstract: Compositions and methods for destroying hydrogen peroxide, for example, contact lens disinfecting amounts of hydrogen peroxide, are disclosed. The present invention utilizes non-mammalian-derived catalase, for example, catalase obtained as a result of the action of one or more microorganisms such as Micrococcus luteus, Aspergillus niger and mixtures thereof, to promote the destruction of hydrogen peroxide. Such non-mammalian-derived catalase has substantial advantages, e.g., enhanced stability, relative to bovine catalase, which is conventionally used in such contact lens-related applications.

Abstract: Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions have improved bioavailability, are capable of low dose volume delivery, and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.

Abstract: A nonirritating, nonionic detergent surfactant composition suitable for application to and cleaning of sensitive tissue, including periocular and ocular tissue, having a low cytotoxicity and high cleaning ability includes a principal nonionic surfactant and at least one auxiliary nonionic surfactant present in the surfactant composition in sufficient amounts to increase the cleaning ability of the principal nonionic surfactant.

Abstract: Retinoid like activity is exhibited by compounds of the formula ##STR1## where R.sub.1 -R.sub.3 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen, lower alkyl, cycloalkyl, lower alkenyl, SR.sub.4 or OR.sub.4 where R.sub.4 is lower alkyl, cycloalkyl or lower alkenyl; Y is selected from a group consisting of pyridazinyl, pyrimidinyl, pyrazinyl or oxazolyl; E is lower alkenyl, lower alkynyl, lower cycloalkyl, lower branched chain alkyl, or is characterized by the formula (CH.sub.2).sub.n where n is 0-5, and Z is H, OH, OR.sub.5, OCOR.sub.5, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH, CH.sub.2 OR.sub.6, CH.sub.2 OCOR.sub.6, or --CHO, CH(OR.sub.7).sub.2, CHOR.sub.8 O, or COR.sub.9, CR.sub.9 (OR.sub.7).sub.2, CR.sub.9 OR.sub.8 O where R.sub.5 is lower alkyl, phenyl or lower alkylphenyl, R.sub.6 is lower alkyl, phenyl or lower alkylphenyl, R.sub.7 is lower alkyl, R.sub.8 is a divalent alkyl radical of 2-5 carbons, and R.

Abstract: The present invention relates to lenses, for example, contact lenses, and to contact lens cases having antimicrobial properties. More particularly, the invention relates to lenses and contact lens cases made from materials which comprise polymeric materials and effective antimicrobial components.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 10 carbons; R.sub.2 and R.sub.3 are hydrogen, or alkyl of 1 to 6 carbons and the substituted ethynyl group occupies either the 2 or the 3 position of the tetrahydronaphthalene nucleus; m is an integer having the value of 0-3; o is an integer having the value 0-4; Y is a phenyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, and imidazolyl, said groups being optionally substituted with one or two R.sub.2 groups; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.

Abstract: Compositions, preferably elastomeric compositions, comprise high refractive index polysiloxane-based cross-linked copolymers and high refractive index polymeric resin components. Such compositions, which have refractive indexes of at least about 1.46, preferably at least about 1.48, are useful in producing foldable intraocular lenses.