Abstract: This disclosure relates to compositions, kits and methods for non-surgical reduction of localized subcutaneous fat such as that associated with a cosmetic fat accumulation. The methods employ compositions having specific concentrations of a salt of deoxycholic acid which provides a superior fat cell necrosis with modest adverse effects. Examples of localized subcutaneous fat are found in the submental area, in particular under the chin.
Abstract: The present invention relates to a topical composition that can be used to treat skin laxity, cellulite and to firm, smooth and/or tone skin.
Type:
Application
Filed:
May 25, 2022
Publication date:
December 8, 2022
Applicant:
ALLERGAN SALES, LLC
Inventors:
Patrick Nido, Kuniko Kadoya, Prithwiraj Maitra, Rahul Mehta, Elizabeth Makino
Abstract: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
Type:
Grant
Filed:
March 15, 2022
Date of Patent:
December 6, 2022
Assignee:
Allergan, Inc.
Inventors:
Jennifer L. Ton, Hemant A. Patel, Ronald C. Bates, Wajdie M. Ahmad
Abstract: A breast implant is provided which includes a filling, or core having a lower overall density relative to silicone gel-filled or saline-filled implant. The core may be a composite including flexible bodies, for example, air-containing or gas-containing bodies, and a gel medium between or around the bodies.
Abstract: Abuse deterrent solid dosage formulations containing 5-({[2-Amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid, and processes for the preparation and administration of these formulations.
Type:
Grant
Filed:
December 8, 2021
Date of Patent:
November 1, 2022
Assignee:
Allergan Holdings Unlimited Company
Inventors:
Tim Costello, Jens Jozef Ceulemans, Eugeen Maria Jozef Jans, Philip Erna H. Heyns
Abstract: Provided herein are poly(ether ester) multi-block copolymers (PEE-MBCP). Also provided herein are injectable delivery systems or pharmaceutical compositions, comprising a PEE-MBCP provided herein, either alone or in combination with a binding protein, such as abicipar. Also provided herein are methods of using these injectable delivery systems or pharmaceutical compositions provided herein for the treatment of ocular disorders.
Type:
Application
Filed:
September 30, 2020
Publication date:
October 20, 2022
Applicant:
Allergan Sales, LLC
Inventors:
Patrick Hughes, Hongwen Rivers, Jie Shen, Johan Zuidema, Henk Haitjema, Christine Hiemstra, Rob Steendam
Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.
Abstract: This disclosure relates to compositions, kits and methods for non-surgical reduction of localized subcutaneous fat such as that associated with a cosmetic fat accumulation. The methods employ compositions having specific concentrations of a salt of deoxycholic acid which provides a superior fat cell necrosis with modest adverse effects. Examples of localized subcutaneous fat are found in the submental area, in particular under the chin.
Abstract: Provided herein are compositions, comprising hyaluronic acid in three different forms. The compositions are in a form of an essentially homogeneous gel with improved rheological properties enabling improved clinical performance.
Type:
Application
Filed:
March 23, 2020
Publication date:
May 26, 2022
Applicant:
ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED
Inventors:
David Dadi SEGAL, Liat GOLDSHAID-ZMIRI, Lital SHKLANOVSKY, Eran GOLDBERG
Abstract: The present invention relates to pharmaceutical compositions, containing 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, (S) 4-[1-(2,3-dimethylphenylpethyl]-1H-imidazole or (S) [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, their use as pharmaceuticals for the treatment of retinal diseases, for retinal neuroprotection and vision enhancement.
Type:
Grant
Filed:
January 14, 2020
Date of Patent:
May 17, 2022
Assignee:
ALLERGAN, INC.
Inventors:
Mohammed I. Dibas, John E. Donello, Daniel W. Gil
Abstract: The present specification discloses SNAP-25 compositions, methods of making ?-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, ?-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing ?-BoNT/A antibodies.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
May 17, 2022
Assignee:
Allergan, Inc.
Inventors:
Ester Fernandez-Salas, Joanne Wang, Patton E. Garay, Lina Wong, D. Dianne Hodges, Kei Roger Aoki
Abstract: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
Type:
Grant
Filed:
October 19, 2021
Date of Patent:
May 10, 2022
Assignee:
Allergan, Inc.
Inventors:
Jennifer L. Ton, Hemant A. Patel, Ronald C. Bates, Wajdie M. Ahmad
Abstract: Abuse deterrent solid dosage formulations containing 5-({[2-Amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid, and processes for the preparation and administration of these formulations.
Type:
Grant
Filed:
September 22, 2021
Date of Patent:
April 26, 2022
Assignee:
Allergan Holdings Unlimited Company
Inventors:
Tim Costello, Jens Jozef Ceulemans, Eugeen Maria Jozef Jans, Philip Erna H. Heyns
Abstract: Formulations and methods for providing progestin-only contraception to a woman including transdermally administering to a woman a formulation having a contraceptively effective amount of progestin-only hormonal agents as part of a contraceptive regimen.
Type:
Application
Filed:
December 29, 2021
Publication date:
April 21, 2022
Applicant:
ALLERGAN SALES, LLC
Inventors:
Charles Ebert, Gary Hoel, Angela Anigbogu, Samir Roy
Abstract: The present invention relates to phenyl urea derivatives useful for the treatment of inflammatory diseases, pharmaceutical compositions containing them and their use as tools or as pharmaceuticals as modulators of the N-formyl peptide receptor (FPR), including FPR1 and FPR2, or as selective agonists of the FPR1 receptor.
Type:
Grant
Filed:
March 28, 2017
Date of Patent:
March 29, 2022
Assignee:
Allergan, Inc.
Inventors:
Tien T. Duong, Richard L. Beard, Michael E. Garst
Abstract: Described herein are methods and compositions for the treatment of ocular conditions and for the improvement of vision parameters using pharmaceutically acceptable ophthalmic pilocarpine formulations. A nonlimiting example of an ocular condition that may be treated with the methods and compositions disclosed herein is presbyopia.
Type:
Grant
Filed:
February 14, 2020
Date of Patent:
March 29, 2022
Assignee:
ALLERGAN, INC.
Inventors:
Michael R. Robinson, Mohammed Dibas, Jaya Giyanani, Anuradha Gore, Sungwook Lee, Haixia Liu, Aileen Morgan, Jihao Zhou
Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.
Abstract: Provided herein are methods of treating a variety of disorders related to fat accumulation in humans with pharmaceutical formulations containing deoxycholic acid.
Type:
Application
Filed:
April 30, 2021
Publication date:
March 10, 2022
Applicant:
Allergan Sales, LLC
Inventors:
Frederick Beddingfield, Elisabeth Sandoval, Nancy Jorgesen, Serge Lichtsteiner, Paul Lizzul, Todd Gross, Christine Somogyi
Abstract: The present specification discloses SNAP-25 compositions, methods of making ?-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, ?-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing ?-BoNT/A antibodies.
Type:
Grant
Filed:
December 17, 2020
Date of Patent:
March 1, 2022
Assignee:
Allergan, Inc.
Inventors:
Ester Fernandez-Salas, Joanne Wang, Patton E. Garay, Lina Wong, D. Diane Hodges, Kei Roger Aoki