Patents Assigned to Allergen Sales, Inc.
  • (2-hydroxy)ethyl-thioureas useful as modulators of &agr;2B adrenergic receptors
    Patent number: 6534542
    Abstract: Compounds of formula (i) and of formula (ii) wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate &agr;2B and/or &agr;2C adrenergic receptors in preference over &agr;2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: March 18, 2003
    Assignee: Allergen Sales, Inc.
    Inventors: Ken Chow, Daniel W. Gil, Wenkui Ken Fang, Michael E. Garst
  • Modified clostridial neurotoxins with altered biological persistence
    Publication number: 20020127247
    Abstract: The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain.
    Type: Application
    Filed: October 31, 2001
    Publication date: September 12, 2002
    Applicant: Allergen Sales, Inc.
    Inventors: Lance E. Steward, Athena Spanoyannis, Kei Roger Aoki, Wei-Jen Lin
  • Compounds having activity as inhibitors of cytochrome P450RAI
    Patent number: 6399774
    Abstract: Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: June 4, 2002
    Assignee: Allergen Sales, Inc.
    Inventors: Jayasree Vasudevan, Alan T. Johnson, Dehua Huang, Roshantha A. Chandraratna
  • ACETYLENES DISUBSTITUTED WITH A 5 ALKYL, ARYL OR HETEROARYL SUBSTITUTED DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY
    Patent number: 6355806
    Abstract: Compounds of the formula wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: March 12, 2002
    Assignee: Allergen Sales, Inc.
    Inventors: Alan T. Johnson, Min Teng, Vidyasagar Vuligonda, Richard L. Beard, Samuel J. Gillett, Tien T. Duong, Roshantha A. Chandraratna
  • 2,4-pentadienoic acid derivatives having retinoid-like biological activity
    Patent number: 6313163
    Abstract: Compounds of formula 1 wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, Y is cyclopropyl optionally substituted with one or two R4 groups, the divalent Y radical being substituted by the Z and —CR1═CR1—CR1═CR1 groups on adjacent carbons; X is S, O, or NR5; n is 1 or 2; R1 and R2 independently are H, lower alkyl or fluoroalkyl; R3 is hydrogen, lower alkyl, Cl or Br; R4 is lower alkyl, fluoroalkyl or halogen; R5 is H or lower alkyl, and B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, —CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, 13 COR7, CR7(OR12)2, CR7OR13O, or tri-lower alkylsilyl, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons, a cycloalkyl group of 5 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 indep
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: November 6, 2001
    Assignee: Allergen Sales, Inc.
    Inventors: Vidyasagar Vuligonda, Roshantha A. Chandraratna