Abstract: The present invention relates to compositions, immunogenic or vaccine compositions and pharmaceutical compositions for the prevention or treatment of peanut allergy in humans. Furthermore, the invention provides methods for preventing or treating of peanut allergy in humans.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
January 26, 2021
Assignee:
ALLERGY THERAPEUTICS (UK) LIMITED
Inventors:
Matthias F. Kramer, Andris Zeltins, Murray A. Skinner, Matthew D. Heath
Abstract: A method of preparing a composition comprising one or more antigens adsorbed to an amino acid wherein said method comprises: (i) mixing a solution of one or more antigens with a solution of the amino acid in an aqueous acid whilst neutralizing the mixture of solutions, thereby forming an adsorbate comprising the one or more antigens and the amino acid; (ii) separating the adsorbate into a desired buffer by cross-flow filtration thereby forming said composition; and (iii) recovering said composition; wherein steps (i) to (iii) are performed in a sterile environment and within a closed system.
Type:
Grant
Filed:
April 20, 2012
Date of Patent:
August 15, 2017
Assignee:
Allergy Therapeutics (UK) Limited
Inventors:
Murray Skinner, Simon Hewings, Duncan Packer, Richard Poland
Abstract: A method of preparing a composition comprising one or more antigens adsorbed to an amino acid wherein said method comprises: (i) mixing a solution of one or more antigens with a solution of the amino acid in an aqueous acid whilst neutralising the mixture of solutions, thereby forming an adsorbate comprising the one or more antigens and the amino acid; (ii) separating the adsorbate into a desired buffer by cross-flow filtration thereby forming said composition; and (iii) recovering said composition; wherein steps (i) to (iii) are performed in a sterile environment and within a closed system.
Type:
Application
Filed:
April 20, 2012
Publication date:
April 17, 2014
Applicant:
ALLERGY THERAPEUTICS (UK) LIMITED
Inventors:
Murray Skinner, Simon Hewings, Duncan Packer, Richard Poland
Abstract: A method of producing a mucosal and systemic immune response in a mammal comprising administering sublingually an effective amount of a composition comprising at least one antigen and a glycolipid adjuvant to said mammal.
Type:
Grant
Filed:
January 15, 2001
Date of Patent:
June 25, 2013
Assignee:
Allergy Therapeutics (UK) Limited
Inventors:
Alan W. Wheeler, Gary Elliott, Christopher Cluff