Abstract: Described herein are oligopeptides useful to inhibit replication in virally infected individuals. In a preferred embodiment of the invention, the oligopeptide is a D-arginine nonamer having N- and C-terminal protecting groups, which, at a 3 uM concentration, exhibits greater than 95% inhibition of HIV replication, in a standard assay.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
August 4, 1998
Assignee:
Allex Biopharmaceuticals, Inc.
Inventors:
Martin Sumner-Smith, Richard W. Barnett, Lorne S. Reid, Nahum Sonenberg