Abstract: The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.
Type:
Grant
Filed:
July 19, 2007
Date of Patent:
September 26, 2017
Assignee:
AllExcel Inc.
Inventors:
Anil Diwan, Ann Louise Onton, Jayant G. Tatake
Abstract: There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.
Type:
Grant
Filed:
January 19, 2006
Date of Patent:
May 8, 2012
Assignee:
AllExcel Inc.
Inventors:
Anil Diwan, Ann Louise Onton, Jayant G. Tatake
Abstract: There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.
Type:
Application
Filed:
January 19, 2006
Publication date:
October 14, 2010
Applicant:
ALLEXCEL, INC.
Inventors:
Anil Diwan, Ann Louise Onton, Jayant G. Tatake
Abstract: The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.
Type:
Application
Filed:
July 19, 2007
Publication date:
September 23, 2010
Applicant:
ALLEXCEL., INC.
Inventors:
Anil R. Diwan, Ann Louise Onton, Jayant G. Tatake