Patents Assigned to Alliance of Cardiovascular Research
  • Priming of pancreatic tumor cells and cancer stem cells to TRAIL-induced apoptosis
    Patent number: 10328056
    Abstract: This invention relates generally to compositions and methods for treatment of pancreatic cancer. The present invention relates more particularly to use of JNK inhibition together with administration of TRAIL to selectively suppress cancer stem cells.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: June 25, 2019
    Assignee: Alliance of Cardiovascular Researches
    Inventors: Eckhard U Alt, Alejandro Recio Boiles, Matthias Ilmer
  • Induced pacemaker and Purkinje cells from adult stem cells
    Patent number: 9913865
    Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: March 13, 2018
    Assignees: InGeneron Inc., Alliance of Cardiovascular Research
    Inventors: Eckhard Alt, Tahereh Karimi