Patents Assigned to ALLIANCE OF CARDIOVASCULAR RESEARCHERS
  • Induced pacemaker and Purkinje cells from adult stem cells
    Patent number: 10905722
    Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: February 2, 2021
    Assignees: INGENERON INC., ALLIANCE OF CARDIOVASCULAR RESEARCHERS
    Inventors: Eckhard Alt, Tahereh Karimi