Abstract: The present disclosure generally relates to improved systems and methods for generating, managing, and sharing digital scripts—which are accessible to patients and/or health care providers and may be accepted by any appropriate prescription dispensary—as well as a comprehensive, real-time source of patient prescription history in compliance with and furtherance of the Meaningful Use regulations. The systems and methods may support the multi-directional flow of script information to improve disease monitoring and treatment, to mitigate patient health risks like undesirable drug interactions, to identify social factors like patient ability to afford prescriptions, and to prevent prescription fraud like forged refills.