Abstract: Provided are a circuit control system and method for dynamically adjusting voltage and frequency. The circuit control system herein includes: a lookup table module configured to store a combined table of voltage-frequency corresponding relation curves of a target circuit under one or more working conditions; a converting module configured to make conversion between a working voltage and a working frequency of the target circuit according to the lookup table module; and a combined adjusting module configured to combinedly adjust the working frequency and the working voltage of the target circuit. With a high degree of automation, the circuit control system herein is safe and reliable for adjusting the working voltage and the working frequency of the target circuit, thereby achieving the effects of adjustment and optimization.