Abstract: The present invention relates to compositions comprising a polymeric matrix or a gel containing functional enzymes capable of re-creating under culture conditions the cell microenvironment existing in vivo. The present invention also relates to devices for cell cultures comprising such compositions, in particular hydrogel and the use thereof to control the chemical microenvironment of a cell culture or mimic physiological or pathological conditions of the in vivo cells. The compositions and the devices described herein could be also used in vitro for evaluating the therapeutic effect of a compound on a determined cell line or on primary cells.

Abstract: The present invention is directed to a recombinant herpesvirus which comprises the GCN4 yeast transcription factor or a part thereof fused to or inserted into glycoprotein H and is capable of binding to a target molecule present on a cell for propagation and production of the herpesvirus. The herpesvirus may comprise additional modification in glycoprotein D and/or glycoprotein B for retargeting the herpesvirus to a diseased cell. The present invention is further directed to a nucleic acid and a vector coding for the gH, a polypeptide comprising the gH, and a cell comprising the herpesvirus, nucleic acid, vector or polypeptide. Moreover, the present invention is directed to a cell having accessible on the surface a target molecule for the GCN4 yeast transcription factor or part thereof and to a method for producing the herpesvirus in said cell.

Abstract: The present invention relates to the field of disease therapy. More specifically, it relates to a retargeted herpesvirus having a heterologous polypeptide fused to glycoprotein H, wherein the polypeptide targets diseased cells. It also relates to a nucleic acid comprising the genome of the herpesvirus of the invention, a vector comprising this nucleic acid and a cell comprising the nucleic acid or the vector. It further relates to killing cells using the herpesvirus of the invention and to methods for growing it in vitro.

Abstract: The present invention relates to a diagnostic/prognostic method for the identification of patients at low risk and high risk of developing colorectal cancer from a sample of human entire blood and/or blood fractions comprising nucleic acids, and to the use of a kit for performing said method.

Abstract: The present invention relates to methods of restoring brain development in individuals with Down syndrome with a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF).

Abstract: A system and method for ray launching in electromagnetic wave propagation modeling. A data-processing system receives a dataset that is representative of one or more structures within an environment, including a first structure that is defined in the dataset as having at least a first surface. The data-processing system partitions at least the first surface into a first plurality of tiles. The data-processing system then projects a first set of ray tubes from a predetermined first point within the environment, to the tiles in the first plurality. Each ray tube in the first set is defined by the vertices of a corresponding tile in the first plurality. The data-processing system evaluates the incidence of bounced ray tubes at a predetermined receive point within the environment and presents a propagation result that is based on the evaluated incidence of the bounced ray tubes.

Abstract: A system and method for ray launching in electromagnetic wave propagation modeling. A data-processing system receives a dataset that is representative of one or more structures within an environment. The system partitions at least a first surface of a first structure into a first plurality of tiles. The system then projects a first set of ray tubes from a predetermined first point within the environment, to the tiles in the first plurality. Each ray tube in the first set is projected to a corresponding tile in the first plurality, based on whether the reference point of the corresponding tile in the first plurality is visible from the transmit point. The data-processing system evaluates the incidence of bounced ray tubes at a predetermined receive point within the environment and then presents a propagation result that is based on the evaluated incidence of the bounced ray tubes.

Abstract: A system and method for ray launching in electromagnetic wave propagation modeling. A data-processing system receives a dataset that is representative of a plurality of structures within an environment. The plurality of structures is defined in the dataset as having a plurality of surfaces. The system then partitions each surface in the plurality of surfaces into a plurality of tiles. The system pre-computes whether i) the reference point of each corresponding tile in each plurality of tiles of each surface is visible or not from ii) the reference point of each possible spawning tile in each other plurality of tiles. The system then projects a first set of ray tubes based on the pre-computed visibility. The system evaluates the incidence of bounced ray tubes at a predetermined receive point within the environment and then presents a propagation result that is based on the evaluated incidence of the bounced ray tubes.

Abstract: The present disclosure relates to a lithium oxygen battery with a non-aqueous flowable semi-solid catholyte comprising an electrolyte, dissolved oxygen and carbonaceous particles which are not soluble in the catholyte. The battery also comprises a lithium anode, electrical contacts, an oxygen inlet, a porous cathode current collector and a pump. The oxygen-enriched catholyte is pumped through the cell of the battery and the oxygen redox reaction may take place on the carbonaceous particles which form a conducting percolating network. Also disclosed is a semi-solid, non-aqueous catholyte comprising an electrolyte, dissolved oxygen and carbonaceous particles; the use of the lithium oxygen battery; and the use in electric vehicle and for stationary applications.

Abstract: Layered double hydroxides organo-modified by 3-(4-hydroxyphenyl)propionic acid (HPPA), by 2-(4-hydroxyphenyl)ethylsulfonic acid or by a hydroxyphenylpropenoic acid, and to composite polymer materials having same. The composite materials are advantageously made of biosourced polymers such as poly(butylene succinate). These composite materials have improved properties over the polymers that make up the composition thereof, and over the composites of the prior art.

Abstract: Supercapacitive bioelectrical systems (SC-BESs) wherein the anode and cathode act as electrodes for a self-powered internal supercapacitor. The BES may further be enhanced by the use of optimized catalysts and enzymes to increase cell voltage and the use of a third capacitive electrode (AdE) short-circuited to the BES cathode and coupled to the BES anode to improve the power output of the self-powered internal supercapacitor.

Abstract: The present invention relates to the field of disease therapy. More specifically, it relates to a retargeted herpesvirus having a heterologous polypeptide fused to glycoprotein H, wherein the polypeptide targets diseased cells. It also relates to a nucleic acid comprising the genome of the herpesvirus of the invention, a vector comprising this nucleic acid and a cell comprising the nucleic acid or the vector. It further relates to killing cells using the herpesvirus of the invention and to methods for growing it in vitro.

Abstract: A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.

Abstract: The invention describes augmented reality glasses (1) for medical applications configured to be worn by a user, comprising a frame (15) that supports a glasses lens (2a, 2b), wherein the frame (15) comprises an RGB lighting system comprising RGB-emitting devices (16a, 16b, 16c) configured to emit light beams (B1, B2, B3); first optical systems (17a, 17b, 17c) configured to collimate at least partially said beams (B1, B2, B3) into collimated beams (B1c; B2c; B3c); wherein the frame (15) further comprises a display (3) configured to be illuminated by the RGB lighting system (16) by means of the collimated beams (B1c; B2c; B3c); to receive first images (I) from a first processing unit (10); to emit the first images (I) as second images (IE1) towards the glasses lens (2a, 2b), wherein the lens (2a, 2b) is configured to reflect the second images (IE1) coming from the display (3) as images projected (IP) towards an internal zone (51) of the glasses corresponding to an eye position zone of the user who is wearing th

Abstract: ‘PA6UNIBO’ is a new cherry tree variety selected for its vigorous growth and excellent yield, as well as its attractive dark red, flavorful fruit. ‘PA6UNIBO’ cherry ripens 10 to 12 days after ‘Burlat’ cherry.

Abstract: A computer-implemented method for surgical planning and/or surgical navigation. A surgical navigation and/or planning system is also provided, that can include aspects of the computer-implemented method, which allows virtual implant planning, and receives real-time data from a tracker. The system can also include one or more hardware components which allow real-time imaging of one or more surgical instruments onto, relative to or over a patient's anatomy. The system and computer-implemented method improve the precision and safety of image based surgery, for example precision placement of bone implants during surgery. A software application is used to manage drill-guide assisted surgery and image-guided surgery. This provides a method and system for Computer Assisted Surgery (CAS) which improves accuracy and safety of a variety of surgical procedures.

Abstract: The present invention relates to silica nanoparticles comprising at least two dyes. Said dyes have a respective relationship of donor-acceptor couple in an energy transfer process and have a molar absorption coefficient ?10,000 M?1 cm?1 for the considered spectral region, a fluorescence quantum yield ?0.01, good overlap integral, according to the Förster theory, between said donor and said acceptor dye; said active compounds may be lipophilic or may present a functionality useful for the introduction of a trialkoxysilane moiety. The dyes provide an efficient energy transfer process. Said nanoparticles are useful as probes in the field of medicine, in particular therapy and diagnostics, more particularly in theranostics, and in the field of analytical chemistry.

Abstract: A sprayable liquid biodegradable formulation comprising biocontrol microorganisms imbedded in a dispersed starch-based bioplastic is effective for delivering biocontrol microorganisms and bioactive compounds to soil, crops and seeds and facilitating positioning of biocontrol agents in close proximity to target pests. After application with conventional spray equipment, water evaporates rapidly and the dispersed bioplastic formula remains, serving as a prolonged growth substrate for the biocontrol microorganisms. Application of the bioplastic dispersion formulation comprising Beauveria bassiana significantly reduced damages caused by the European Corn Borer in corn and the Tarnished Plant Bug in cotton. Applying a formulation of spores of a non-aflatoxigenic A. flavus isolate resulted in a 97% reduction of aflatoxin contamination of corn. The bioplastic dispersion formulation is effective in delivering crystal Bacillus thuringiens endotoxins to European Corn Borer larvae, causing 72% mortality.

Abstract: A method of calculation that is simultaneously parallel and graphic able to run on clusters with various operating systems such as for example Windows HPC and Unix. A program realized according to such a method is able to perform a parallel calculation on a cluster, by means of a message-passing system (for example MPI), and at the same time to visualise an interactive graphic interface (GUI). The program according to the method runs in parallel and executes the calculation in parallel as defined by user instructions that are provided through a GUI. The GUI is generated, managed and visualised within the cluster itself and therefore it is not necessary to connect to it by an external PC. The developed method is able to perform the reconstruction for example of tomographic images in parallel and to show the graphic results on video, even partially and interactively.

Abstract: Variety Denomination ‘PA7UNIBO’ is a novel cherry tree derived from a seedling of unknown cross which was planted at Vignola, Modena Province, Italy. The genus and species (cultivar) of ‘PA7UNIBO’ is Prunus avium. It was initially propagated by grafting to root stocks of varying vigor and, after testing in districts and plantings of differing types, proved to have qualities for a promising new cultivar for the market.