Abstract: A trans-dermal medication application cell for temporary attachment to the skin of a patient to facilitate the diffusion of medication solution from the cell's interior to the skin of a patient where it will be absorbed. A housing non-reactive with medication solutions is closed by a micro-porous diaphragm or membrane. A formed perforated medical foam sheet is secured to the housing and, in use, to the skin of a patient by a medical adhesive. A release sheet and vapor barrier secured to the foam sheet block exterior access to the micro-porous membrane and adhesive coated foam sheet prior to application to the patient's skin. A self locking and sealing plug closes the filling aperture in the housing in the principal invention embodiment.

Abstract: A medication application system comprising a container for medication adhesively secured to the unbroken skin of a patient. The container is cup-shaped and closed on its open side by a micro-porous diaphragm or membrane through which the medication passes from the container to the skin surface where it is absorbed. Particular means are described for adhering the container to the skin and for sealing the container prior to its use. Various pharmaceutically effective medications in differing concentrations found to be effectively dispensed from the container, are described.

Abstract: A blind riveting and sealing system for sealing circular openings in sheet type materials and for securing together plural sheets. Each of the sheets to be secured together has an identical size hole for accommodating the rivet of the invention in a force fit relationship. Additionally, one of the sheets has a reduced diameter step in the rivet receiving hole to form a resilient annular locking flange. The rivet of the invention has a necked down portion to form a beveled seat face. This beveled seat face engages the resilient annular locking flange to lock the rivet in position and seal the circular openings in the sheets.