Patents Assigned to Almirall Prodesfarma S.A.
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Patent number: 8129405Abstract: The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide in powder inhalant form, and methods of using it for treatment of respiratory disorders.Type: GrantFiled: January 21, 2011Date of Patent: March 6, 2012Assignee: Almirall Prodesfarma S.A.Inventors: Maria Dolors Fernandez Forner, Maria Prat Quiñones, María Antonia Buil Albero
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Patent number: 7897617Abstract: The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with steroids.Type: GrantFiled: May 26, 2010Date of Patent: March 1, 2011Assignee: Almirall Prodesfarma S.A.Inventors: Maria Dolors Fernandez Forner, Maria Prat Quiñones, Maria Antonia Buil Albero
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Patent number: 7189741Abstract: The invention relates to indolyl piperidinyl derivatives of formula (I) wherein: A1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group; A2 represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group; W1 represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; W2 represents a 3–10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups; R1 represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group; and R2 represents a carboxyl group; and pharmaceutically acceptable salts thereof; to processes for their preparation; to pharmaceutical compositions containing them; and to their medical use as antihistaminic and antiallergic agents.Type: GrantFiled: October 26, 2001Date of Patent: March 13, 2007Assignee: Almirall Prodesfarma S.A.Inventors: Silvia Fonquerna Pou, Lluis Pages Santacana, Carles Puig Duran, Lidia Soca Pueyo
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Patent number: 7060824Abstract: This invention relates to new therapeutically useful 8-(disubstituted)phenyl-6,9-dihydro-5H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine-5-one and 8-phenyl-6,9-dihydro-5H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-5-one derivatives of formula (I): wherein: —X—C—Y— represents (a) or (b) to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medical uses as potent and selective inhibitors of phosphodiesterase 5 (PDE 5).Type: GrantFiled: August 1, 2001Date of Patent: June 13, 2006Assignee: Almirall Prodesfarma, S.A.Inventors: Bernat Vidal Juan, Cristina Esteve Trias, Jordi Gracia Ferrer, José Manuel Prieto Soto
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Patent number: 7034016Abstract: 8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives of formula (I): or a pharmaceutically acceptable salt thereof processes for their preparation, pharmaceutical compositions containing them and their use as PDE 5 inhibitors.Type: GrantFiled: January 25, 2002Date of Patent: April 25, 2006Assignee: Almirall Prodesfarma, S.A.Inventors: Jordi Gracia Ferrer, Joan Feixas Gras, José Manuel Prieto Soto, Armando Vega Noverola, Bernat Vidal Juan
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Patent number: 6943253Abstract: The invention relates to new 6-phenylpyrrolopyrimidine derivatives of formula (I): wherein: —X—C—Y— represents or —X—C—Y— represents and to their use as selective cyclic GMP specific phosphodiesterase (PDE 5)inhibitors, processes for producing them, intermediates used in their production, compositions containing them and their applicability in medical treatment of the human or animal body.Type: GrantFiled: December 6, 2002Date of Patent: September 13, 2005Assignee: Almirall Prodesfarma S.A.Inventors: Bernat Vidal Juan, Jordi Gracia Ferrer, José Manuel Prieto Soto, Armando Vega Noverola
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Patent number: 6750226Abstract: A compound according to formula (I) wherein: is a phenyl ring, a C4 to C9 heteroaromatic compound containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl group; which shows high affinity for muscarinic M3 receptors (Hm3).Type: GrantFiled: January 14, 2002Date of Patent: June 15, 2004Assignee: Almirall-Prodesfarma, S.A.Inventors: Dolors Fernandez Forner, Maria Prat Quiñones, Maria Antonia Buil Albero
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Patent number: 6683096Abstract: Indolylpiperidine compounds of formula (I) wherein: A1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoyl or hydroxyalkylene group; A2 represents a single bond, an alkylene or alkenylene group; W represents a single bond or a phenylene or furanylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; R2 represents a hydrogen or halogen atom or an alkyl or alkoxy group; and R3 represents a carboxyl group or a tetrazolyl group. The present invention provides novel indolylpiperidine compounds having imporved antihistamine and antiallergic activity.Type: GrantFiled: December 4, 2001Date of Patent: January 27, 2004Assignee: Almirall Prodesfarma, S.A.Inventors: Lluis Pages Santacana, Silvia Fonquerna Pou, Carles Puig Duran, Maria Dolors Fernandez Forner
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Patent number: 6518303Abstract: 2-Phenylpyran-4-one derivatives of formula (I): wherein: R1 represents an alkyl or —NR4R5 group, wherein R4 and R5 each independently represents a hydrogen atom or an alkyl group; R2 represents an alkyl, C3-C7 cycloalkyl, pyridyl, thienyl, naphthyl, tetrahydronaphthyl or indanyl group, or a phenyl group which may be unsubstituted or substituted by one or more halogen atoms or alkyl, trifluoromethyl, hydroxy, alkoxy, methylthio, amino, mono- or dialkylamino, hydroxalkyl or hydroxycarbonyl groups; R3 represents a methyl, hydroxymethyl, alkoxymethyl, C3-C7 cycloalkoxymethyl, benzyloxymethyl, hydroxycarbonyl, nitrile, trifluoromethyl or difluoromethyl group or a CH2—R6 group wherein R6 represents an alkyl group; and X represents a single bond, an oxygen atom, a sulfur atom or a methylene group; or pharmaceutically acceptable salts thereof, processes for their production and synthetic intermediates used in said processes, pharmaceutical compositions containing them and their useType: GrantFiled: March 16, 2001Date of Patent: February 11, 2003Assignee: Almirall Prodesfarma S.A.Inventors: Maria Isabel Crespo Crespo, Juan Miguel Jimenez Mayorga, Carles Puig Duran, Lidia Soca Pueyo
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Publication number: 20020183326Abstract: Heterocyclic compounds of formula (I), 1Type: ApplicationFiled: January 8, 2002Publication date: December 5, 2002Applicant: ALMIRALL PRODESFARMA, S.A.Inventors: Jordi Gracia Ferrer, M. Isabel Crespo Crespo, Armando Vega Noverola, Andres Fernandez Garcia
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Patent number: 6407108Abstract: Heterocyclic compounds of formula(I), wherein R1 represents a hydrogen atom or a —(CH2)m—Y group, wherein m is an integer from 0 to 4 and Y represents an alkyl, haloalkyl, alkoxy, alkoxycarbonyl, C3-C7 cycloalkyl, norbornyl or phenylalkenyl group, or an aromatic group which aromatic group {circumflex over ( )} may optionally be substituted by one or more halogen atoms; R2 represents an aromatic group which aromatic group may optionally be substituted by one or more halogen atoms or alkyl, alkoxy, C3-C6 cycloalkoxy, methylenedioxy, nitro, dialkylamino or trifluoromethyl groups, and R3 represents a hydrogen or halogen atom or an alkyl group, and pharmaceutically acceptable salts thereof, processes for preparing the same are disclosed herein. The compounds are phosphodiesterase 4 inhibitors.Type: GrantFiled: January 28, 2000Date of Patent: June 18, 2002Assignee: Almirall Prodesfarma, S.A.Inventors: Jordi Gracia Ferrer, Ma Isabel Crespo Crespo, Armando Vega Noverola, Andres Fernandez Garcia