Abstract: The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient. The inhalation device further comprises an advancing mechanism for advancing a counter means each time the inhalation device has been activated by the patient so that a powder dose has been released into the powder channel.
Type:
Application
Filed:
January 17, 2013
Publication date:
December 25, 2014
Applicant:
Almirall, S.A.
Inventors:
Martin Herder, Gerhard Ludanek, Ingo Mett, Joachim Schmidt
Abstract: The invention refers to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when actuated by the patient.
Type:
Application
Filed:
January 17, 2013
Publication date:
December 25, 2014
Applicant:
Almirall, S.A.
Inventors:
Martin Herder, Gerhard Ludanek, Ingo Mett, Joachim Schmidt
Abstract: Topical pharmaceutical compositions are described comprising: (a) bexarotene; (b) a corticosteroid; and (c) a carrier or vehicle. Said compositions are useful for the treatment of skin disorders.
Abstract: A compound which is a hydroxyquinolinone derivative of formula (I), in the form of a racemate, a stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in, for example, normalising the lung function of a human patient.
Abstract: New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
Type:
Application
Filed:
July 23, 2012
Publication date:
September 18, 2014
Applicant:
ALMIRALL, S.A.
Inventors:
Paul Robert Eastwood, Jordi Bach Taña, Lluis Miquel Pages Santacana
Abstract: In order to improve the administration of powdered pharmaceuticals, the invention proposes a storage system for powdered pharmaceuticals, in particular for use or integration in a powder inhaler, for receiving a multiplicity of doses of at least one medically active substance, with at least two storage spaces (4) which are separate from each other and are each intended to hold a multiplicity of doses of a medically active substance, and the invention also proposes an inhaler for powdered pharmaceuticals, the inhaler comprising such a pharmaceutical powder cartridge system (1) as an integral part or as an exchangeable part.
Abstract: Provided is a pharmaceutical composition comprising: (i) 3-(2-hydroxy-2,2-dithien-2- ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo-[2.2.2]octane or an enantiomer, mixture of enantiomers, or a racemate thereof, wherein an anion X?with a single negative charge is associated with the positive charge of the nitrogen atom; and (ii) a phosphodiesterase IV inhibitor and methods of using the same.
Type:
Grant
Filed:
July 11, 2013
Date of Patent:
August 12, 2014
Assignee:
Almirall, S.A.
Inventors:
Maria Dolors Fernandez Forner, Maria Prat Quinones, Maria Antonia Buil Albero
Abstract: The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
Type:
Grant
Filed:
April 3, 2009
Date of Patent:
July 8, 2014
Assignee:
Almirall, S.A.
Inventors:
Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Bernet Vidal Juan, Nuria Aguilar Izquierdo
Abstract: Compounds having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
Type:
Application
Filed:
May 21, 2012
Publication date:
June 19, 2014
Applicant:
ALMIRALL, S.A.
Inventors:
Paul Robert Eastwood, Jacob Gonzalez Rodriguez, Elena Gomez Castillo, Jordi Bach Taña
Abstract: The present invention provides a compound which is a hydroxyquinolinone derivative of formula (I), in the form of a racemate, a stereoisomer or a mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for use in a method of treating a pulmonary disease or condition associated with ?2 adrenergic receptor activity in a mammal, in which the compound is administered by the inhalatory route at a metered nominal dose of less than 5 ?g.
Abstract: The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH).
Type:
Application
Filed:
August 12, 2013
Publication date:
January 2, 2014
Applicant:
Almirall, S.A.
Inventors:
Julio Cesar CASTRO PALOMINO LARIA, Emma Terricabras Belart, Montserrat Erra Sola, Eloisa Navarro Romero, Siliva Fonquerna Pou, Aranzazu Cardus Figueras, Maria Estrella Lozoya Toribio
Abstract: New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
Type:
Application
Filed:
November 24, 2011
Publication date:
November 21, 2013
Applicant:
ALMIRALL, S.A.
Inventors:
Jacob Gonzalez Rodriguez, Bernat Vidal Juan, Laura Vidal Gispert, Jordi Bach Taña
Abstract: To provide an inhalation device which has improved use properties, particularly advanced moisture protection while in use, an inhalation device (1) for powder drugs is proposed comprising at least one storage chamber (13) for accommodating a plurality of drug powder doses and a dosing device which includes at least one dosing slider (15) which is movable approximately with a translatory movement in a dosing slider passage (16) at least from a filling position into an emptying position, wherein the inhalation device (1) further includes a device for inhalation-triggered automatic movement of the dosing slider (15) from its filling position into the emptying position and a return device for automatic movement of the dosing slider (15) back into the filling position.
Type:
Grant
Filed:
December 21, 2007
Date of Patent:
October 29, 2013
Assignee:
Almirall, S.A.
Inventors:
Martin Herder, Gerhard Ludanek, Ingo Mett
Abstract: The present disclosure relates to a mesylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the ?2 receptor.
Type:
Grant
Filed:
December 15, 2009
Date of Patent:
October 22, 2013
Assignee:
Almirall, S.A.
Inventors:
Francesc Carrera Carrera, Carlos Puig Duran, Iolanda Marchueta Hereu, Enrique Moyes Valls
Abstract: The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH).
Type:
Grant
Filed:
August 8, 2008
Date of Patent:
September 17, 2013
Assignee:
Almirall, S.A.
Inventors:
Julio Cesar Castro Palomino Laria, Emma Terricabras Belart, Montserrat Erra Sola, Eloisa Navarro Romero, Silvia Fonquerna Pou, Aranzazu Cardus Figueras, Maria Estrella Lozoya Toribio
Abstract: A process for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof, which process comprises: a) reacting, in a xylene solvent, a compound of formula (V) having P1 and P2 protecting groups, with a compound of formula (IV), to give a compound of formula (III); and b) effecting a P1 deprotection step and a P2 deprotection step to give a compound of formula (I); and optionally c) preparing a pharmaceutically acceptable salt of a compound of formula (I); wherein the compounds of formulas III, IV, and V are described in the specification.
Abstract: The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide in combination with a steroid, and methods of using it for treatment of respiratory disorders.
Type:
Grant
Filed:
January 20, 2012
Date of Patent:
August 20, 2013
Assignee:
Almirall, S.A.
Inventors:
Maria Dolors Fernandez Forner, Maria Prat Quinones, Maria Antonia Buil Albero
Abstract: The present disclosure is directed to the sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid, pharmaceutically acceptable solvates thereof, pharmaceutical combinations thereof, and methods of treatment.
Type:
Grant
Filed:
March 11, 2010
Date of Patent:
August 6, 2013
Assignee:
Almirall, S.A.
Inventors:
Nuria Garcia Gonzalez, Francesc Carrera Carrera, Monserrat Julia Jane, Laurent Debethune, Xavier Serra Masia