Patents Assigned to Alpha-O-Peptides AG
  • Flagellin-containing protein nanoparticles as a vaccine platform
    Patent number: 10245318
    Abstract: The present invention relates to self-assembling protein nanoparticles constructed from suitable oligomerization domains and further incorporating the TLR5 binding protein flagellin as an adjuvant molecule. Furthermore, the invention relates to the use of such nanoparticles for vaccination.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: April 2, 2019
    Assignee: ALPHA-O PEPTIDES AG
    Inventors: Peter Burkhard, Senthil Kumar Raman, Sara Maria Paulillo, Matteo Piazza, Caroline Kulangara, Christian Mittelholzer
  • FLAGELLIN-CONTAINING PROTEIN NANOPARTICLES AS A VACCINE PLATFORM
    Publication number: 20160324958
    Abstract: The present invention relates to self-assembling protein nanoparticles constructed from suitable oligomerization domains and further incorporating the TLR5 binding protein flagellin as an adjuvant molecule. Furthermore, the invention relates to the use of such nanoparticles for vaccination.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 10, 2016
    Applicant: ALPHA-O PEPTIDES AG
    Inventors: Peter BURKHARD, Senthil Kumar RAMAN, Sara Maria PAULILLO, Matteo PIAZZA, Caroline KULANGARA, Christian MITTELHOLZER
  • SELF-ASSEMBLING PEPTIDE NANOPARTICLES AS VACCINES AGAINST INFECTION WITH NOROVIRUS
    Publication number: 20140242104
    Abstract: Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and displaying the P domain of the norovirus protein VP1 are described. The nanoparticles of the invention consist of aggregates of a continuous peptide chain comprising two coiled coil oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants for the prevention and treatment of norovirus infections.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 28, 2014
    Applicant: ALPHA-O PEPTIDES AG
    Inventors: Peter Burkhard, Caroline Kulangara
  • Self-assembling peptide nanoparticles useful as vaccines
    Patent number: 8546337
    Abstract: Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and/or B-cell epitopes are described. The nanoparticles of the invention consist of aggregates of a continuous peptidic chain comprising two oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes and/or B-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: October 1, 2013
    Assignee: Alpha-O-Peptides AG
    Inventor: Peter Burkhard