Patents Assigned to Alpharma AS
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Publication number: 20140328930Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: January 9, 2014Publication date: November 6, 2014Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Joseph Stauffer, James Jones
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Patent number: 8877247Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: February 22, 2010Date of Patent: November 4, 2014Assignee: Alpharma Pharmaceuticals LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Patent number: 8846104Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: February 13, 2012Date of Patent: September 30, 2014Assignee: Alpharma Pharmaceuticals LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Patent number: 8685443Abstract: A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.Type: GrantFiled: April 23, 2010Date of Patent: April 1, 2014Assignee: Alpharma Pharmaceuticals LLCInventor: Garth Boehm
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Patent number: 8685444Abstract: A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.Type: GrantFiled: April 23, 2010Date of Patent: April 1, 2014Assignee: Alpharma Pharmaceuticals LLCInventor: Garth Boehm
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Publication number: 20140056975Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.Type: ApplicationFiled: November 4, 2013Publication date: February 27, 2014Applicant: Alpharma Pharmaceuticals LLCInventors: Alfred Liang, Francis Joseph Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
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Publication number: 20140037721Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.Type: ApplicationFiled: October 10, 2013Publication date: February 6, 2014Applicant: Alpharma pharmaceuticals LLCInventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
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Publication number: 20140030343Abstract: The invention relates to compositions and methods for attenuating opioid induced respiratory depression. Such compositions comprise opioids and sequestered opioid antagonists in a multi-particulate dosage formulation.Type: ApplicationFiled: October 25, 2011Publication date: January 30, 2014Applicant: Alpharma Pharmaceuticals LLCInventors: Michael J. Lamson, Veeraindar Goli
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Patent number: 8623418Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.Type: GrantFiled: December 16, 2008Date of Patent: January 7, 2014Assignee: Alpharma Pharmaceuticals LLCInventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
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Publication number: 20130337020Abstract: Provided herein is a method of treating a condition in a host that is responsive to an agonist, the method comprising administering to the host a multi-layer pharmaceutical composition comprising the agonist and an antagonist thereof, wherein the agonist and antagonist are not in direct contact with one another in the intact form of the composition.Type: ApplicationFiled: August 21, 2013Publication date: December 19, 2013Applicant: Alpharma Pharmaceuticals LLCInventors: Frank Matthews, Alfred C Liang, Frank Johnson
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Publication number: 20130122065Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.Type: ApplicationFiled: January 7, 2013Publication date: May 16, 2013Applicant: ALPHARMA PHARMACEUTICALS LLCInventor: Alpharma Pharmaceuticals LLC
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Patent number: 8415121Abstract: Improved process for the isolation of laidlomycin from a fermentation broth includes increasing the pH of the fermentation broth and centrifuging the pH adjusted fermentation broth, resulting in an aqueous layer and a wet solid layer containing laidlomycin. After the aqueous layer is removed, the wet solid layer containing laidlomycin is dried. The process provides an efficient and high yielding method.Type: GrantFiled: September 22, 2010Date of Patent: April 9, 2013Assignee: Alpharma, LLCInventor: Robert Sheridan
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Publication number: 20130072514Abstract: The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) <724>, is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.Type: ApplicationFiled: March 6, 2012Publication date: March 21, 2013Applicant: Alpharma Pharmaceuticals, LLCInventors: Garth Boehm, Alfred Liang
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Publication number: 20120244191Abstract: Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.Type: ApplicationFiled: June 8, 2012Publication date: September 27, 2012Applicant: ALPHARMA, LLCInventors: James Skinner, Doug Rupp
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Patent number: 8227235Abstract: Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.Type: GrantFiled: September 21, 2009Date of Patent: July 24, 2012Assignee: Alpharma, LLCInventors: James Skinner, Doug Rupp
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Publication number: 20120142925Abstract: A process is provided for the N-demethylation of certain morphinans by reaction with ?-chloroethyl chloroformate followed by hydrolysis of the resulting intermediate.Type: ApplicationFiled: May 25, 2007Publication date: June 7, 2012Applicant: ALPHARMA ApSInventors: Ole Heine Kvernenes, Anne Mette Nygard, Audun Hegges, Harald Haivorsen
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Patent number: 8158156Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: June 19, 2007Date of Patent: April 17, 2012Assignee: Alpharma Pharmaceuticals, LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Publication number: 20120082718Abstract: Described is a pellet composition comprising a core element comprising morphine sulfate, a filler and a binder, wherein the morphine sulfate, calculated as the anhydrous form, comprises about 50 wt % to about 85 wt % of the total weight of the core element; and a coating disposed on at least a portion of the core element, the coating comprising an insoluble matrix polymer which is insoluble at pH 1 to 7.5; an enteric polymer which is insoluble at pH 1 to 4 and soluble at pH 6 to 7.5; and an acid soluble polymer which is soluble at a pH of 1 to 4, wherein the ratio of the acid soluble polymer to the enteric polymer is 1.45:1 to 2.5:1 on a weight basis. Also described are dosage forms comprising the disclosed pellets.Type: ApplicationFiled: December 12, 2011Publication date: April 5, 2012Applicant: Alpharma Pharmaceuticals, LLCInventor: Alfred C. Liang
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Publication number: 20120039962Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: October 21, 2011Publication date: February 16, 2012Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Joseph Stauffer, James Jones
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Publication number: 20110082303Abstract: Improved process for the isolation of laidlomycin from a fermentation broth includes increasing the pH of the fermentation broth and centrifuging the pH adjusted fermentation broth, resulting in an aqueous layer and a wet solid layer containing laidlomycin. After the aqueous layer is removed, the wet solid layer containing laidlomycin is dried. The process provides an efficient and high yielding method.Type: ApplicationFiled: September 22, 2010Publication date: April 7, 2011Applicant: Alpharma Inc.Inventor: Robert Sheridan