Patents Assigned to Alpharma AS
  • Cytotoxic modified lactoferrin peptides
    Patent number: 6890902
    Abstract: The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and lipophilic amino acids as compared to the native lactoferrin sequence, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing such peptides, pharmaceutical compositions containing such peptides and use of the peptides as medicaments, particularly as antibacterials or anti-tumoural agents.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: May 10, 2005
    Assignee: Alpharma AS
    Inventors: John Sigurd Svendsen, Oystein Rekdal, Baldur Sveinbjornsson, Lars Vorland
  • Bioactive peptides
    Publication number: 20030148936
    Abstract: The present invention provides a cytotoxic 7 to 25-mer peptide with three or more catonic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing the peptides, pharmaceutical compositions containing them, and their use as medicaments, particularly as antibacterial or antitumor agents.
    Type: Application
    Filed: February 27, 2001
    Publication date: August 7, 2003
    Applicant: ALPHARMA AS.
    Inventors: John Sigurd Svendsen, Oystein Rekdal, Baldur Sveinbjornsson, Lars Vorland
  • Bioactive peptides
    Publication number: 20030022821
    Abstract: The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and lipophilic amino acids as compared to the native lactoferrin sequence, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing such peptides, pharmaceutical compositions containing such peptides and use of the peptides as medicaments, particularly as antibacterials or anti-tumoural agents.
    Type: Application
    Filed: February 27, 2001
    Publication date: January 30, 2003
    Applicant: ALPHARMA AS
    Inventors: John Sigurd Svenden, Oystein Rekdal, Baldur Sveinbjornsson, Lars Vorland
  • Method of substantially continuously separating two compounds using a moving bed or a simulated moving bed
    Publication number: 20020017492
    Abstract: The present invention relates to a method of separating a first solute A and a second solute B using (simulated) moving bed chromatography. According to the present invention at least one of a) a feed stream; and b) a desorbent stream comprises an organic solvent. The use of different solvent liquids for the feedstream and the desorbent stream results in an increased difference in partition coefficients for solute A and solute B. According to the present invention it is possible to obtain solute A in an extract stream in a form which is more concentrated in comparison to the concentration of solute A in the feedstream.
    Type: Application
    Filed: June 1, 2001
    Publication date: February 14, 2002
    Applicant: Alpharma AS and Technische Universiteit Delft
    Inventors: Thomas Birger Jensen, Hugo Arthur Honore Billiet, Lucas Antonius Maria Van Der Wielen