Patents Assigned to Alpharma AS
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Patent number: 7815934Abstract: A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit and a therapeutic agent in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.Type: GrantFiled: September 22, 2003Date of Patent: October 19, 2010Assignee: Alpharma Pharmaceuticals, LLCInventor: Garth Boehm
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Publication number: 20100152221Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
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Publication number: 20100151014Abstract: Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Frank Matthews, Garth Boehm, Lijuan Tang, Frank Johnson, Joseph Stauffer
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Publication number: 20100143417Abstract: Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.Type: ApplicationFiled: September 21, 2009Publication date: June 10, 2010Applicant: ALPHARMA INC.Inventors: Skinner James, Rupp Doug
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Publication number: 20100143483Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: February 22, 2010Publication date: June 10, 2010Applicant: ALPHARMA PHARMACEUTICALS, LLC.Inventors: Frank MATTHEWS, Garth Boehm, Lijuan Tang, Alfred Liang
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Publication number: 20100075398Abstract: Disclosed herein are purified bacteriophage preparations that effectively lyse a plurality of C. perfringens strains. In one embodiment, a purified bacteriophage preparation includes four or more C. perfringens-specific bacteriophage, wherein each bacteriophage has lytic activity against at least five C. perfringens strains. In another embodiment, the purified bacteriophage preparation includes five or more C. perfringens-specific bacteriophage.Type: ApplicationFiled: December 15, 2008Publication date: March 25, 2010Applicants: ALPHARMA, INC., INTRALYTIX, INC.Inventors: Jeremy J. Mathers, Alexander Sulakvelidze
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Patent number: 7682634Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: March 6, 2009Date of Patent: March 23, 2010Assignee: Alpharma Pharmaceuticals, LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Patent number: 7682633Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: GrantFiled: March 6, 2009Date of Patent: March 23, 2010Assignee: Alpharma Pharmaceuticals, LLCInventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Publication number: 20100035832Abstract: This invention relates to a novel class of antibiotic agents, more specifically to macrolides comprising an oxazolidinone structure, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them.Type: ApplicationFiled: January 12, 2006Publication date: February 11, 2010Applicant: ALPHARMA APSInventors: Audun Heggelund, Kjell Undheim
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Publication number: 20100022634Abstract: An animal feed additive composition comprises an effective amount of a laidlomycin, a carrier, magnesium sulfate, and silicon dioxide. Other embodiments include methods of making the animal feed additive compositions, and the use of a laidlomycin in the manufacture of an animal feed additive for increasing the efficiency of feed utilization and rate of weight gain in domestic animals.Type: ApplicationFiled: June 15, 2009Publication date: January 28, 2010Applicant: ALPHARMA INC.Inventors: Steven Holmes, Janice Cacace
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Publication number: 20090312541Abstract: The present invention relates to novel intermediates of formula VII, or an acid addition salt or a solvate thereof, wherein R1 is —(CO)NH2, —CH2NH2 or —CN; R2?R3?H or R2 and R3 together form a cyclic boronate or borate ester; X is a helping group selected from the group consisting of i) a five or six membered heterocyclic aromatic ring and derivatives thereof comprising at least one N-atom being a part of an imine-group, wherein said N-atom forms the point of connection to the cyclohexapeptide ring, and ii) tetrazolyl and derivatives thereof for which a nitrogen atom forms the point of connection to the cyclohexapeptide ring, and a process for the preparation of caspofungin utilizing said intermediates.Type: ApplicationFiled: June 13, 2008Publication date: December 17, 2009Applicant: ALPHARMA APSInventors: Audun Heggelund, Ole Heine Kvernenes, Vidar Bjornstad
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Publication number: 20090304793Abstract: The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) <724>, is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.Type: ApplicationFiled: April 6, 2009Publication date: December 10, 2009Applicant: Alpharma, Inc.Inventor: Garth Boehm
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Publication number: 20090275739Abstract: A novel and improved method for purification of glycopeptides, especially glycopeptide antibiotics. The method comprises contacting a solution of the glycopeptide to an ion exchange chromatography material. The product of this method has a surprisingly high purity.Type: ApplicationFiled: October 27, 2005Publication date: November 5, 2009Applicant: ALPHARMA APSInventors: Lene Aassveen, Kamilla Lundhaug, Kjersti Aastorp Hirth
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Publication number: 20090196890Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.Type: ApplicationFiled: December 17, 2008Publication date: August 6, 2009Applicant: Alpharma Pharmaceuticals, LLCInventors: Alfred Liang, Franklin Johnson, Xiaohong Qi
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Publication number: 20090162451Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: March 6, 2009Publication date: June 25, 2009Applicant: ALPHARMA PHARMACEUTICALS, LLC.Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Publication number: 20090162450Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: March 6, 2009Publication date: June 25, 2009Applicant: ALPHARMA PHARMACEUTICALS, LLC.Inventors: Frank Matthews, Garth Boehm, Lijuan Tang, Alfred Liang
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Publication number: 20090155357Abstract: The present invention provides alcohol resistant oral dosage pharmaceutical forms and methods of using such oral dosage forms to avoid dose dumping if the dosage form is taken together with alcohol.Type: ApplicationFiled: July 31, 2006Publication date: June 18, 2009Applicant: ALPHARMA INC.Inventor: Goutam Muhuri
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Publication number: 20090131466Abstract: Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.Type: ApplicationFiled: September 4, 2008Publication date: May 21, 2009Applicant: ALPHARMA, INC.Inventors: Alfred Liang, Joseph Stauffer, James Jones
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Publication number: 20090005842Abstract: The present invention provides cooling sheets for application to an extremity of a mammal, and methods for making and using such cooling sheets.Type: ApplicationFiled: October 12, 2007Publication date: January 1, 2009Applicant: ALPHARMA INC., ANIMAL HEALTH DIVISIONInventor: Wen Yan Lin
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Publication number: 20080234503Abstract: A method for purification of the antibiotic mupirocin (pseudomonic acid A) which comprises: a) Causing or allowing precipitation of mupirocin from an aqueous solution thereof; b) Recovering the precipitate; c) Dissolving the recovered precipitate in an organic solvent.Type: ApplicationFiled: February 21, 2006Publication date: September 25, 2008Applicant: ALPHARMA APSInventors: Marc Antonius Theodorus Bisschops, Tiemen Geert Pieter Reijns, Anita Mathiesen, Lene Aassveen