Patents Assigned to Alpheus Medical, Inc.
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Patent number: 11980777Abstract: Disclosed are methods of producing randomized ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.Type: GrantFiled: June 26, 2023Date of Patent: May 14, 2024Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11975156Abstract: Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.Type: GrantFiled: June 26, 2023Date of Patent: May 7, 2024Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11872414Abstract: Disclosed are methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.Type: GrantFiled: June 26, 2023Date of Patent: January 16, 2024Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11865372Abstract: Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.Type: GrantFiled: March 24, 2023Date of Patent: January 9, 2024Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11730980Abstract: Disclosed are methods of using planar acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of flat piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a modulated planar acoustic wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.Type: GrantFiled: August 11, 2021Date of Patent: August 22, 2023Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11724132Abstract: Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.Type: GrantFiled: October 5, 2022Date of Patent: August 15, 2023Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11617904Abstract: Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.Type: GrantFiled: April 29, 2022Date of Patent: April 4, 2023Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11491353Abstract: Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.Type: GrantFiled: August 11, 2021Date of Patent: November 8, 2022Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling
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Patent number: 11318332Abstract: Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.Type: GrantFiled: August 11, 2021Date of Patent: May 3, 2022Assignee: Alpheus Medical, Inc.Inventors: Vijay Agarwal, Braden Eliason, Jeremy Ling