Patents Assigned to Alps Pharmaceutical Ind. Co., Ltd.
  • Patent number: 11266671
    Abstract: A composition containing L-arginine and a glycosyl compound of formula (I): in which R is a moiety formed of a monosaccharide, a disaccharide, or an oligosaccharide including three to five monosaccharides; and the composition contains the glycosyl compound and L-arginine in a molar ratio of 1:1.6 to 1:3.0. Also disclosed is a method for preparing such a composition, as well as a composition prepared by the method.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 8, 2022
    Assignee: ALPS Pharmaceutical Ind. Co., Ltd.
    Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
  • Patent number: 11110109
    Abstract: A water-soluble composition including an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and ascorbic acid or an alkali salt of ascorbic acid. The O-glycosyl flavonoid compound is rutin, isoquercitrin, or hesperidin, and a molar ratio between the O-glycosyl flavonoid compound and the sugar alcohol is 1:4.0-12.0. Also provided is a method for making the above-described water-soluble composition by combining the O-glycosyl flavonoid compound, L-arginine, the sugar alcohol, and ascorbic acid or an alkali salt thereof to form a mixture, and heating it at 110° C.-140° C. to melt the mixture.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: September 7, 2021
    Assignee: ALPS Pharmaceutical Ind. Co., Ltd.
    Inventors: Naoto Yamaguchi, Yui Sudaka, Mitsunori Ono
  • Patent number: 10918654
    Abstract: A water-soluble composition containing rutin, L-arginine, and an alkali salt of ascorbic acid in which the molar ratio between the rutin, L-arginine, and the alkali salt of ascorbic acid is 1:1.6-3.0:0.1-2.0.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: February 16, 2021
    Assignee: ALPS Pharmaceutical Ind. Co., Ltd.
    Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
  • Patent number: 10617705
    Abstract: A water-soluble pharmaceutical composition containing isoquercitrin, L-arginine, and ascorbic acid or an alkali salt thereof, in which the molar ratio between the isoquercitrin, L-arginine, and the ascorbic acid or alkali salt is 1:1.6-2.6:0.16-1.95.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: April 14, 2020
    Assignee: Alps Pharmaceutical Ind. Co., Ltd.
    Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
  • Patent number: 9827262
    Abstract: A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: November 28, 2017
    Assignee: ALPS Pharmaceuticals, Ind. Co., Ltd.
    Inventors: Kazunobu Minami, Shinji Taniwaki, Akiko Katsumata
  • Patent number: 9308216
    Abstract: A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: April 12, 2016
    Assignee: Alps Pharmaceuticals Ind. Co., Ltd.
    Inventors: Kazunobu Minami, Shinji Taniwaki, Akiko Katsumata
  • Publication number: 20060235076
    Abstract: The invention relates to a therapy of an infection with a drug resistant bacterium wherein a characteristic of multivalent phenol derivatives and/or extracts from “Tara” which enhance the activity of ?-lactam antibiotics on the drug resistant bacteria is utilized. Specifically, the invention relates to an enhancer of ?-lactam antibiotics comprising a multivalent phenol derivative or its pharmaceutically acceptable salt, a pharmaceutical composition comprising a ?-lactam antibiotic and a multivalent phenol derivative and/or extract from “Tara” for the therapy of an infection with a drug resistant bacterium, a disinfectant for the same, and a functional food comprising a multivalent phenol derivative and/or extract from “Tara”.
    Type: Application
    Filed: January 28, 2004
    Publication date: October 19, 2006
    Applicants: ALPS PHARMACEUTICAL IND. CO., LTD., MicroBiotech Inc.
    Inventors: Tomihiko Higuchi, Hirofumi Shibata, Yoichi Sato, Nobuhisa Takaishi, Kazuyoshi Kawazoe, Kotaro Murakami
  • Publication number: 20060229262
    Abstract: The present invention provides a pharmaceutical composition or a method for treatment of infections with a drug resistant bacterium including a flavonoid as an active ingredient, and also, a pharmaceutical composition or a method for treatment of infections with a drug resistant bacterium and a disinfectant including a flavonoid which can enhance efficacy of a ?-lactam antibiotic, and said ?-lactam antibiotic.
    Type: Application
    Filed: June 9, 2006
    Publication date: October 12, 2006
    Applicants: Tomihiko Higuchi, Alps pharmaceutical Ind. Co., Ltd.
    Inventors: Tomihiko Higuchi, Hirofumi Shibata, Takayuki Nakada, Yoichi Sato
  • Patent number: 6294526
    Abstract: A novel screening system for detecting a non-antibiotic compound having &bgr;-lactam-sensitivity-inducing activity comprising a non-antibiotic compound and a &bgr;-lactam antibiotic two times serially diluted series and a pharmaceutical composition having anti-MRSA activity comprising a flavone derivative and a &bgr;-lactam antibiotic.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: September 25, 2001
    Assignee: Alps Pharmaceutical Ind. Co., Ltd.
    Inventors: Tomihiko Higuchi, Yoichi Sato, Shoji Murasugi
  • Patent number: 5955631
    Abstract: The invention provides a method for industrial purification of Capsaicin in high purity from capsinoids (Capsaicin and analogues), more specifically, a method for industrial purification of Capsaicin which comprises contacting capsinoids containing Capsaicin in a hydrophilic solvent with a silver compound in an aqueous solution to form a Capsaicin-silver complex which is soluble in water, and recovering highly pure Capsaicin from the Capsaicin-silver complex without chromatography.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: September 21, 1999
    Assignee: Alps Pharmaceutical Ind. Co., Ltd.
    Inventors: Hisashi Segi, Shuji Yamada, Satoshi Kato, Shoji Murasugi
  • Patent number: 4045450
    Abstract: The optical resolution of DL-pantolactone is effected by reacting DL-pantolactone or its alkali salt derived therefrom, respectively, with an optically active N-substituted aminophenylpropanol of the general formula: ##STR1## wherein R.sub.1 is a phenyl group which may be substituted and R.sub.2 is an aralkyl group in which the benzene ring may bear a substituent, or its mineral acid addition salt; separating the resulting diastereomers by the aid of difference in their dissolubility; and decomposing them to give the corresponding optical antipodes. This method can provide the antipodes in high purity and yield and can be carried out with ease.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: August 30, 1977
    Assignee: Alps Pharmaceutical Ind. Co., Ltd.
    Inventors: Akikazu Kinugasa, Toshio Okuda, Makoto Goto, Mitsuo Saito