Patents Assigned to Alps Pharmaceuticals Ind. Co., Ltd.
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Patent number: 11266671Abstract: A composition containing L-arginine and a glycosyl compound of formula (I): in which R is a moiety formed of a monosaccharide, a disaccharide, or an oligosaccharide including three to five monosaccharides; and the composition contains the glycosyl compound and L-arginine in a molar ratio of 1:1.6 to 1:3.0. Also disclosed is a method for preparing such a composition, as well as a composition prepared by the method.Type: GrantFiled: April 23, 2019Date of Patent: March 8, 2022Assignee: ALPS Pharmaceutical Ind. Co., Ltd.Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
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Patent number: 11110109Abstract: A water-soluble composition including an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and ascorbic acid or an alkali salt of ascorbic acid. The O-glycosyl flavonoid compound is rutin, isoquercitrin, or hesperidin, and a molar ratio between the O-glycosyl flavonoid compound and the sugar alcohol is 1:4.0-12.0. Also provided is a method for making the above-described water-soluble composition by combining the O-glycosyl flavonoid compound, L-arginine, the sugar alcohol, and ascorbic acid or an alkali salt thereof to form a mixture, and heating it at 110° C.-140° C. to melt the mixture.Type: GrantFiled: October 22, 2019Date of Patent: September 7, 2021Assignee: ALPS Pharmaceutical Ind. Co., Ltd.Inventors: Naoto Yamaguchi, Yui Sudaka, Mitsunori Ono
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Patent number: 10918654Abstract: A water-soluble composition containing rutin, L-arginine, and an alkali salt of ascorbic acid in which the molar ratio between the rutin, L-arginine, and the alkali salt of ascorbic acid is 1:1.6-3.0:0.1-2.0.Type: GrantFiled: February 13, 2020Date of Patent: February 16, 2021Assignee: ALPS Pharmaceutical Ind. Co., Ltd.Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
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Patent number: 10617705Abstract: A water-soluble pharmaceutical composition containing isoquercitrin, L-arginine, and ascorbic acid or an alkali salt thereof, in which the molar ratio between the isoquercitrin, L-arginine, and the ascorbic acid or alkali salt is 1:1.6-2.6:0.16-1.95.Type: GrantFiled: September 25, 2019Date of Patent: April 14, 2020Assignee: Alps Pharmaceutical Ind. Co., Ltd.Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
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Patent number: 9827262Abstract: A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.Type: GrantFiled: April 1, 2016Date of Patent: November 28, 2017Assignee: ALPS Pharmaceuticals, Ind. Co., Ltd.Inventors: Kazunobu Minami, Shinji Taniwaki, Akiko Katsumata
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Patent number: 9308216Abstract: A method of obtaining a rutin-rich extract from a plant and a rutin-rich extract of Uncaria elliptica thus obtained.Type: GrantFiled: October 22, 2012Date of Patent: April 12, 2016Assignee: Alps Pharmaceuticals Ind. Co., Ltd.Inventors: Kazunobu Minami, Shinji Taniwaki, Akiko Katsumata
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Publication number: 20060235076Abstract: The invention relates to a therapy of an infection with a drug resistant bacterium wherein a characteristic of multivalent phenol derivatives and/or extracts from “Tara” which enhance the activity of ?-lactam antibiotics on the drug resistant bacteria is utilized. Specifically, the invention relates to an enhancer of ?-lactam antibiotics comprising a multivalent phenol derivative or its pharmaceutically acceptable salt, a pharmaceutical composition comprising a ?-lactam antibiotic and a multivalent phenol derivative and/or extract from “Tara” for the therapy of an infection with a drug resistant bacterium, a disinfectant for the same, and a functional food comprising a multivalent phenol derivative and/or extract from “Tara”.Type: ApplicationFiled: January 28, 2004Publication date: October 19, 2006Applicants: ALPS PHARMACEUTICAL IND. CO., LTD., MicroBiotech Inc.Inventors: Tomihiko Higuchi, Hirofumi Shibata, Yoichi Sato, Nobuhisa Takaishi, Kazuyoshi Kawazoe, Kotaro Murakami
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Pharmaceutical composition for treatment of infection with drug resistant bacterium and disinfectant
Publication number: 20060229262Abstract: The present invention provides a pharmaceutical composition or a method for treatment of infections with a drug resistant bacterium including a flavonoid as an active ingredient, and also, a pharmaceutical composition or a method for treatment of infections with a drug resistant bacterium and a disinfectant including a flavonoid which can enhance efficacy of a ?-lactam antibiotic, and said ?-lactam antibiotic.Type: ApplicationFiled: June 9, 2006Publication date: October 12, 2006Applicants: Tomihiko Higuchi, Alps pharmaceutical Ind. Co., Ltd.Inventors: Tomihiko Higuchi, Hirofumi Shibata, Takayuki Nakada, Yoichi Sato -
Patent number: 6294526Abstract: A novel screening system for detecting a non-antibiotic compound having &bgr;-lactam-sensitivity-inducing activity comprising a non-antibiotic compound and a &bgr;-lactam antibiotic two times serially diluted series and a pharmaceutical composition having anti-MRSA activity comprising a flavone derivative and a &bgr;-lactam antibiotic.Type: GrantFiled: July 23, 1998Date of Patent: September 25, 2001Assignee: Alps Pharmaceutical Ind. Co., Ltd.Inventors: Tomihiko Higuchi, Yoichi Sato, Shoji Murasugi
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Patent number: 5955631Abstract: The invention provides a method for industrial purification of Capsaicin in high purity from capsinoids (Capsaicin and analogues), more specifically, a method for industrial purification of Capsaicin which comprises contacting capsinoids containing Capsaicin in a hydrophilic solvent with a silver compound in an aqueous solution to form a Capsaicin-silver complex which is soluble in water, and recovering highly pure Capsaicin from the Capsaicin-silver complex without chromatography.Type: GrantFiled: July 16, 1998Date of Patent: September 21, 1999Assignee: Alps Pharmaceutical Ind. Co., Ltd.Inventors: Hisashi Segi, Shuji Yamada, Satoshi Kato, Shoji Murasugi
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Patent number: 4045450Abstract: The optical resolution of DL-pantolactone is effected by reacting DL-pantolactone or its alkali salt derived therefrom, respectively, with an optically active N-substituted aminophenylpropanol of the general formula: ##STR1## wherein R.sub.1 is a phenyl group which may be substituted and R.sub.2 is an aralkyl group in which the benzene ring may bear a substituent, or its mineral acid addition salt; separating the resulting diastereomers by the aid of difference in their dissolubility; and decomposing them to give the corresponding optical antipodes. This method can provide the antipodes in high purity and yield and can be carried out with ease.Type: GrantFiled: February 12, 1976Date of Patent: August 30, 1977Assignee: Alps Pharmaceutical Ind. Co., Ltd.Inventors: Akikazu Kinugasa, Toshio Okuda, Makoto Goto, Mitsuo Saito