Abstract: Methods for modulating hormonal pathways involving the progesterone receptor in a subject with a neurodegenerative disorder, are provided. Progesterone receptor activity is modulated by administering an effective amount of an progesterone receptor modulating pharmacological agent to a subject such that the progesterone receptor modulating pharmacological agent interacts with the progesterone receptor and alters the expression of a protein associated with the neurodegenerative disease.
Abstract: Methods and compositions are disclosed for selectively decreasing protein levels in a central nervous system, meningial, immune system, blood, or muscle cell by administrating a pharmacological agent. In particular, methods and compositions that interfere with SOD-1 protein synthesis or stability, and decrease cellular levels of the protein are disclosed.
Type:
Application
Filed:
November 28, 2006
Publication date:
June 14, 2007
Applicant:
ALSGEN, INC.
Inventors:
Daniel Benjamin, Robert Henrie, Monica Errico, Brian Rex, Justin Bracken, Sean Scott