Patents Assigned to Altarex Corp.
  • Therapeutic compositions that produce an immune response
    Patent number: 7361346
    Abstract: The invention provides a method for stimulating the production of antibodies to a cryptic epitope on a soluble antigen by administering to a patient having such a cryptic epitope a binding agent that binds to the soluble antigen and forming a complex between the binding agent and the soluble antigen, wherein the cryptic epitope is exposed and the patient generates antibodies that bind to the cryptic epitope.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: April 22, 2008
    Assignee: Altarex Corp.
    Inventors: Ragupathy Madiyalakan, Antoine A. Noujaim, Richard P. Baum, Birgit Schultes, Beatrice Leveugle, Fernando Kreutz
  • Therapeutic binding agents against MUC-1 antigen and methods for their use
    Publication number: 20050048059
    Abstract: The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a binding agent that can specifically bind to an epitope that comprises both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for the use of such therapeutic compositions in the treatment of cancer.
    Type: Application
    Filed: January 7, 2004
    Publication date: March 3, 2005
    Applicant: AltaRex Corp.
    Inventors: Ragupathy Madiyalakan, Weimin Qi, Birgit Schultes
  • Therapeutic binding agents against MUC-1 antigen and methods for their use
    Patent number: 6716966
    Abstract: The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a binding agent that can specifically bind to an epitope that comprises both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for the use of such therapeutic compositions in the treatment of cancer.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: April 6, 2004
    Assignee: AltaRex Corp.
    Inventor: Ragupathy Madiyalakan
  • Therapeutic method and composition utilizing antigen-antibody complexation and presentation by dendritic cells
    Patent number: 6689355
    Abstract: Disclosed are methods and compositions for use in immunotherapy. These methods and compositions are particularly useful for exploiting dendritic cells to present an antigen to a patient, particularly where the patient has a disease associated with the antigen. The invention provides methods for treating a patient having a disease associated with an antigen. The methods according to the invention comprise combining ex vivo an antigen and an antigen-presenting cell binding agent specific for the antigen, and administering the composition to a patient suffering from a disease associated with the antigen, wherein the patient receives a therapeutic benefit.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: February 10, 2004
    Assignee: AltaRex Corp.
    Inventors: Birgit Corinna Schultes, Antoine Noujaim, Dean L. Mann
  • Method and composition for reconforming multi-epitopic antigens to initiate an immune response
    Patent number: 6241985
    Abstract: The invention concerns methods and compositions for intiating and/or enhancing an immune response by contacting a binding reagent with a soluble antigen, wherein the binding reagent-antigen pair generates an immune response to the antigen.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: June 5, 2001
    Assignee: Altarex Corp.
    Inventors: Ragupathy Madiyalakan, Antoine A. Noujaim, Richard P. Baum, Birgit Schultes