Patents Assigned to Altea Therapeutics Corporation
-
Patent number: 8116860Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.Type: GrantFiled: January 22, 2008Date of Patent: February 14, 2012Assignee: Altea Therapeutics CorporationInventors: Bernadette Messier, Zoran Novakovic, Jeremiah Peter O'Leary, Regina Spiehl, Wendy E. Bowerman, Stephen Wilson Braun, Jonathan Eppstein, David Farquhar, Mark James Fisher, Uros Kascak, Erin Koch Henkel, Loren J. Lantz, Stuart McRae
-
Patent number: 8016811Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.Type: GrantFiled: October 24, 2003Date of Patent: September 13, 2011Assignee: Altea Therapeutics CorporationInventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
-
Patent number: 7758561Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.Type: GrantFiled: February 6, 2004Date of Patent: July 20, 2010Assignee: Altea Therapeutics CorporationInventor: Jonathan A. Eppstein
-
Patent number: 7392080Abstract: The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) the porator array comprising: i) a top surface, with a removable adhesive attached to the top surface, the top surface containing two concentric electrical contact rings for contacting the interface connection port at the anode and the cathode upon removal of the adhesive layer; ii) a bottom surface comprising a tissue interface membrane, the tissue interface membrane further comprising a substrate with at least one porator contained on or within the substrate, the bottom surface further comprising an adhesive layer for aType: GrantFiled: March 11, 2003Date of Patent: June 24, 2008Assignee: Altea Therapeutics CorporationInventors: Jonathan Eppstein, Stuart McRae, Alan Smith
-
Patent number: 7141034Abstract: A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is constructed of a material that is destroyed upon forming the micropore. The transdermal drug delivery device also comprises at least one reservoir and a controller for controlling the formation of said micropore by the porator and destroying the porator after the formation of the micropore.Type: GrantFiled: March 11, 2003Date of Patent: November 28, 2006Assignee: Altea Therapeutics CorporationInventors: Jonathan Eppstein, Stuart McRae, Joseph Papp
-
Patent number: 6922578Abstract: An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum.Type: GrantFiled: September 25, 2003Date of Patent: July 26, 2005Assignees: SpectRx, Inc., Altea Therapeutics CorporationInventors: Jonathan A. Eppstein, Mark A. Samuels, Michael R. Hatch
-
Publication number: 20040220456Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.Type: ApplicationFiled: February 6, 2004Publication date: November 4, 2004Applicant: Altea Therapeutics CorporationInventor: Jonathan A. Eppstein
-
Patent number: 6730028Abstract: A method and device for forming artificial openings in a biological membrane with a pyrotechnic charge that is exploded in a controlled manner in proximity of the biological membrane to form the artificial opening(s) therein. The method and device are useful in connection with transdermal delivery and monitoring applications.Type: GrantFiled: October 29, 2001Date of Patent: May 4, 2004Assignee: Altea Therapeutics CorporationInventors: Jonathan A. Eppstein, Michael R. Hatch, Joseph Papp, Mark L. Faupel, Krishna Kumar
-
Patent number: 6692456Abstract: The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.Type: GrantFiled: June 8, 2000Date of Patent: February 17, 2004Assignee: Altea Therapeutics CorporationInventors: Jonathan A. Eppstein, Michael R. Hatch, Joseph Papp
-
Patent number: D574500Type: GrantFiled: May 19, 2006Date of Patent: August 5, 2008Assignee: Altea Therapeutic CorporationInventors: Erin Melissa Koch, Mark James Fisher, Jeremiah Peter O'Leary, Stephen Wilson Braun, Uros Kascak, Loren J. Lantz, Zoran Novakovic
-
Patent number: D605775Type: GrantFiled: July 24, 2008Date of Patent: December 8, 2009Assignee: Altea Therapeutics CorporationInventors: Erin Melissa Koch, Mark James Fisher, Jeremiah Peter O'Leary, Stephen Wilson Braun, Uros Kascak, Loren J. Lantz, Zoran Novakovic