Abstract: 4-alkyl-1,4-dihydropyridines with activity antagonistic of the PAF-"acether" of formula (I) are described, in which R is a saturated alkyl chain C1-2; R' is a saturated or unsaturated C1-16 lineal, branched or cyclic chain that can be interrupted by an oxygen atom and can also represent a 2-(N-morpholine) ethyl group; n is 2 or 3, X is oxygen, sulphur or SO2; Ar represents an aromatic ring that cannot be phenyl when X=S and n=2. The compounds (I) can be prepared (a) by reaction of (II) with (III) and with (IV); or (b) by reacting (V) with (VI) and (IV); or (c) by reaction of (VII) with (VI). In these formulas the different radicals have the meaning given above.
Type:
Grant
Filed:
August 3, 1992
Date of Patent:
March 29, 1994
Assignee:
Alter, S.A.
Inventors:
Carlos Sunkel, Miguel Fau de Casa-Juana, Luis Santos, Pilar Ortega, Jaime Priego
Abstract: 4-alkyl-1,4-dihyropyridines, with PAF-antagonist activity, of formula (I) wherein R is saturated C.sub.1 -C.sub.4, R' is saturated C.sub.1 -C.sub.6 alkyl which may be interrupted by an oxygen atom, or 2-tetrahydrofurfuryl and R.sup.2 is saturated C.sub.1 -C.sub.4 or phenyl, the compound wherein R is methyl, R' is ethyl and R.sup.2 is phenyl remain excluded, are described.The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet activating factor.
Type:
Grant
Filed:
December 27, 1991
Date of Patent:
January 5, 1993
Assignee:
Alter, S.A.
Inventors:
Carlos Sunkel, Miguel Fau De Casa-Juana, Luis Santos, Pilar Ortega, Jaime Priego, Mariano Sanchez-Crespo
Abstract: Novel quaternary ammonium salts of general formula (I) ##STR1## wherein: R is a saturated or unsaturated, linear or branched alkyl radical of C.sub.1 to C.sub.8.R' is a saturated or unsaturated, linear or branched alkyl radical of C.sub.1 to C.sub.12, or a benzyl radical.n is a number equal to 2 or 3.X.sup..theta. is a halogenide anion, such as Cl.sup..theta., Br.sup..theta., I.sup..theta., are used as phase transfer catalysts, in heterogeneous ionic reactions wherein the reagents are in different phase and have different polarity.
Type:
Grant
Filed:
September 26, 1988
Date of Patent:
November 14, 1989
Assignee:
Alter, S.A.
Inventors:
Carlos Sunkel, Miguel Fay de Casa Juana, Fernando Dorrego, Basilio Pando, Julio Alvarez-Builla, Juan J. Vaquero, Carlos Galera, Maria L. Vazquez
Abstract: The present invention refers to new 1,4-dihydropyridines, to their obtention processes and to their use as antithrombotic drugs. Said new 1,4-dihdyropyridines have the following general formula (I) ##STR1## wherein R represents hydrogen or a saturated or unsaturated alkyl group, with a linear or branched chain of 1 to 8 carbon atoms,R.sup.1 represents an alkyl radical with a linear, branched or cyclic, saturated or unsaturated chain of 1 to 12 carbon atoms, which may be interrupted by an oxygen or by a 2-(N-salicylamido)ethyl group,n is a number equal to 1 or 2.These new 1,4-dihydropyridines are obtained by processes based on the Hantzch reaction or on modifications thereof.
Type:
Grant
Filed:
May 18, 1987
Date of Patent:
November 1, 1988
Assignee:
Alter, S.A.
Inventors:
Carlos Sunkel, Miguel Fau de Casa-Juana, Fernando Dorrego, Jaime Priego, Pilar Ortega, Javier Cillero
Abstract: The present invention is concerned with purifying the mixed ester, ethylene glycol 1-/2-(p-chlorophenoxy)-2-methylpropionate/-2-nicotinate by passing said compound in oily form through a layer of Super-Cel and charcoal and then crystallizing said compound from a mixture of benzene/petroleum ether. This compound has hypolipidemic properties.
Type:
Grant
Filed:
August 4, 1975
Date of Patent:
April 12, 1977
Assignee:
Alter, S.A.
Inventors:
Carlos Sunkel Letelier, Fernando CilleroGrafulla