Patents Assigned to Alton Ochsner Medical Foundation
  • Identification of a novel retrovirus associated with primary sclerosing cholangitis and autoimmune hepatitis
    Patent number: 6787303
    Abstract: The present invention relates first, to the identification of a retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) Crohn's disease and ulcerative colitis. The present invention further relates to methods for using the PSC associated retroviral nucleotides for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in patient samples. The present invention also relates to methods for using and targeting the PSC associated retroviral POL nucleotides in gene therapy protocols for the treatment of PSC, AIH, Crohn's disease or ulcerative disease in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in tissue samples.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: September 7, 2004
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Andrew L. Mason, Lizhe Xu, Linsheng Guo
  • Inhibition of cellular proliferation by oligonucleotide binding to a chromosomal binding site for p53 protein
    Patent number: 6645944
    Abstract: The present invention provides methods for inhibiting cell growth by providing a growing cell with an oligonucleotide capable of binding to a chromosomal binding site for p53 protein. Moreover, in a preferred embodiment these methods can be used for preventing and treating cancer.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: November 11, 2003
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Richard Re, Julia Cook
  • Identification of a novel retrovirus associated with primary biliary cirrhosis and autoimmune disorders
    Patent number: 6468737
    Abstract: The present invention relates, first, to the discovery, identification, and characterization of novel nucleic acid molecules, that are associated with PBC, Sjögren's syndrome, scleroderma, SLE, autoimmune thyroiditis and various other connective tissue disorders. The novel nucleotide sequences of the present invention are retroviral in origin and are indicative of a PBC retrovirus which bears a strong correlation with PBC. The present invention is based, in part, on the Applicant's data which is the first evidence to suggest that PBC patient's tissue may harbor a transmissible agent. The association of a retroviral infectious agent with PBC was first demonstrated by Applicants in vitro by co-culture of periportal lymph nodes derived from patients at time of transplantation and healthy biliary epithelium cells.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: October 22, 2002
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Andrew L. Mason, Lizhe Xu, James Neuberger
  • Inhibition of cellular proliferation in vitro by oligonucleotide binding to a chromosomal binding site for p53 protein
    Patent number: 6303328
    Abstract: The present invention provides methods for inhibiting cell growth by providing a growing cell with an oligonucleotide capable of binding to a chromosomal binding site for p53 protein. Moreover, in a preferred embodiment these methods can be used for preventing and treating cancer.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: October 16, 2001
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Richard Re, Julia Cook
  • Oligonucleotide which binds to a chromosomal binding site for p53 protein
    Patent number: 5936079
    Abstract: The present invention provides methods for inhibiting cell growth by providing a growing cell with an oligonucleotide capable of binding to a chromosomal binding site for p53 protein. Moreover, in a preferred embodiment these methods can be used for preventing and treating cancer.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: August 10, 1999
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Richard Re, Julia Cook