Patents Assigned to Altor Bioscience, LLC
  • Compositions comprising IL-15N72D-based molecules and bacillus calmette-guerin (BCG)
    Patent number: 12268731
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: April 18, 2024
    Date of Patent: April 8, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based molecules with anti-CD20 antibody and methods of use
    Patent number: 12268732
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: June 7, 2024
    Date of Patent: April 8, 2025
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 12233116
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: September 25, 2024
    Date of Patent: February 25, 2025
    Assignee: Altor Bioscience, LLC.
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based molecules and methods of treating a neoplasia
    Patent number: 12186372
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: January 7, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Fusion molecules and IL-15 variants
    Patent number: 12168680
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: December 17, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • Methods of treating a neoplasia with IL-15-based molecules and CTLA-4 antibody
    Patent number: 12097244
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 22, 2023
    Date of Patent: September 24, 2024
    Assignee: Altor BioScience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Compositions comprising IL-15-based molecules and immune checkpoint inhibitor antibodies
    Patent number: 11992516
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: May 28, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11975059
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: December 1, 2023
    Date of Patent: May 7, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based fusions to IL-7 and IL-21
    Patent number: 11965007
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: April 23, 2024
    Assignee: Altor Bioscience, LLC.
    Inventor: Hing C. Wong
  • Method for treating neoplasia with an anti-CD38 antibody and an IL-15:IL-15R complex
    Patent number: 11925676
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: March 12, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Method of treating cancer with composition comprising IL-15-based molecules and BCG
    Patent number: 11890323
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: February 6, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11872272
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: January 16, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 11845783
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: December 19, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-based molecules and methods of use thereof
    Patent number: 11679144
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: June 20, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Fusion molecules and IL-15 variants
    Patent number: 11673932
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 13, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11612645
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: August 19, 2022
    Date of Patent: March 28, 2023
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11571470
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: February 7, 2023
    Assignee: Altor Bioscience LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Fusion molecules and IL-15 variants
    Patent number: 11498950
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: November 15, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-based molecules and methods of use thereof
    Patent number: 11471511
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 18, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Multimeric IL-15-based molecules
    Patent number: 11369679
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: June 28, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong