Patents Assigned to ALZA Corporation
  • Patent number: 10342963
    Abstract: An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44,90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: July 9, 2019
    Assignee: ALZA CORPORATION
    Inventors: Michael T. Cao, Richard L. Keenan, Joseph C. Trautman
  • Patent number: 9919151
    Abstract: Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode).
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 20, 2018
    Assignees: Incline Therapeutics, Inc., Alza Corporation
    Inventors: Bradley E. White, Paul Hayter, John Lemke, Scot Satre, Corinna X. Chen, Brian W. Read, Jason E. Dougherty
  • Patent number: 9645179
    Abstract: Electrotransport drug delivery devices, system and methods of using configured to determine if a current is present between the anode and cathode when drug is not intended to be delivered by the device. These devices/systems may include an off-current module to determine that any current (e.g., which may be inferred by measuring potential difference between the anode and cathode of the device) flowing between the anode and cathode is below a threshold value when the device is not supposed to be delivering drug, thereby preventing unintended delivery of drug and/or alerting a user that unintended delivery of drug may occur.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: May 9, 2017
    Assignees: Incline Therapeutics, Inc., Alza Corporation
    Inventors: Bradley E. White, John Lemke, Paul Hayter, Corinna X. Chen, Brian W. Read, Jason E. Dougherty
  • Patent number: 9573717
    Abstract: Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: February 21, 2017
    Assignee: ALZA CORPORATION
    Inventors: Mahmoud Ameri, Michel J. N. Cormier, Scott Sellers, Yuh-Fun Maa
  • Publication number: 20160374955
    Abstract: A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
    Type: Application
    Filed: September 13, 2016
    Publication date: December 29, 2016
    Applicant: ALZA Corporation
    Inventors: Robert M. Gale, Jay Audett, Rama V. Padmanabhan, Michel J.N. Cormier, Allison Luciano, Eric N. Silverberg, Paul B. Foreman
  • Patent number: 9522122
    Abstract: A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: December 20, 2016
    Assignee: ALZA Corporation
    Inventor: Jay Douglas Audett
  • Patent number: 9446004
    Abstract: A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: September 20, 2016
    Assignee: ALZA CORPORATION
    Inventors: Robert M. Gale, Jay Audett, Rama V. Padmanabhan, Michel J. N. Cormier, Allison Luciano, Eric N. Silverberg, Paul B. Foreman
  • Patent number: 9421351
    Abstract: An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: August 23, 2016
    Assignee: ALZA CORPORATION
    Inventors: Joseph C. Trautman, Lorin Olson
  • Patent number: 9387315
    Abstract: A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: July 12, 2016
    Assignee: Alza Corporation
    Inventors: Joseph C. Trautman, Richard L. Keenan
  • Patent number: 9364656
    Abstract: A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: June 14, 2016
    Assignees: Incline Therapeutics, Inc., Alza Corporation
    Inventors: Zita S. Netzel, John Lemke, David Seward, Brian W. Read, Bradley E. White, Corinna X. Chen, Paul Hayter
  • Publication number: 20160106686
    Abstract: A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Applicant: ALZA Corporation
    Inventor: Jay Douglas Audett
  • Patent number: 9295714
    Abstract: An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: March 29, 2016
    Assignee: Alza Corporation
    Inventors: Mahmoud Ameri, Michel J. N. Cormier, Yuh-Fun Maa, Peter E. Daddona, Marika Kamberi
  • Publication number: 20160058747
    Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
    Type: Application
    Filed: November 6, 2015
    Publication date: March 3, 2016
    Applicant: ALZA CORPORATION
    Inventor: Robert M. Gale
  • Patent number: 9248105
    Abstract: A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: February 2, 2016
    Assignee: ALZA Corporation
    Inventor: Jay Douglas Audett
  • Patent number: 9205059
    Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: December 8, 2015
    Assignee: ALZA Corporation
    Inventor: Robert M. Gale
  • Patent number: 9205090
    Abstract: A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: December 8, 2015
    Assignee: ALZA Corporation
    Inventors: Jay Audett, Jianye Wen, Eli J. Goldman, Robert M. Gale, Allison Luciano, Paul B. Foreman, Eric N. Silverberg
  • Patent number: 9192749
    Abstract: An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44, 90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: November 24, 2015
    Assignee: Alza Corporation
    Inventors: Joseph C. Trautman, Richard Keenan, Michael T. Cao
  • Patent number: 9144549
    Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 29, 2015
    Assignee: ALZA CORPORATION
    Inventors: Suneel K. Gupta, Diane R Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel
  • Publication number: 20150265548
    Abstract: A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.
    Type: Application
    Filed: June 9, 2015
    Publication date: September 24, 2015
    Applicant: ALZA Corporation
    Inventor: Jay Douglas Audett
  • Publication number: 20150246007
    Abstract: A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 3, 2015
    Applicant: ALZA Corporation
    Inventors: Robert M. Gale, Jay Audett, Rama V. Padmanabhan, Michel J.N. Cormier, Allison Luciano, Eric N. Silverberg, Paul B. Foreman