Patents Assigned to ALZA Corporation
  • Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification
    Patent number: 7390780
    Abstract: A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: June 24, 2008
    Assignee: Alza Corporation
    Inventors: Shi-Kun Huang, Samuel Zalipsky
  • Reusable, spring driven autoinjector
    Patent number: 7381201
    Abstract: The present invention provides a reusable spring driven autoinjector. The drive mechanism of the autoinjector of the present invention includes one or more drive springs formed of a shape memory alloy. Therefore, by alternating the shape memory alloy forming the one or more drive springs between austenite phase before an injection and a martensite phase after injection, the reusable autoinjector of the present invention is capable of providing an injection force that is higher than the compressive force required to cock the drive mechanism in preparation for a subsequent injection operation.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: June 3, 2008
    Assignee: Alza Corporation
    Inventors: Scott Gilbert, Pedro de la Sema
  • Osmotic Delivery System Flow Modulator Apparatus and Method
    Publication number: 20080071253
    Abstract: An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.
    Type: Application
    Filed: September 16, 2007
    Publication date: March 20, 2008
    Applicant: ALZA CORPORATION
    Inventors: Lewis Peterson, Fred Maruyama, Houdin Dehnad, Lawton Hom, Kevin Sly, Craig Davis, John Peery
  • Expandable osmotic composition and coating suspension
    Patent number: 7338663
    Abstract: The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.
    Type: Grant
    Filed: June 28, 2003
    Date of Patent: March 4, 2008
    Assignee: ALZA Corporation
    Inventors: Shaoling Li, Liang-Chang Dong, Padmaja Shivanand, Patrick S. L. Wong
  • Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia
    Publication number: 20080039775
    Abstract: An apparatus and method for transdermally delivering a biologically active agent to prevent or treat osteopenia, comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
    Type: Application
    Filed: March 15, 2007
    Publication date: February 14, 2008
    Applicant: ALZA CORPORATION
    Inventors: Mahmoud Ameri, Michel Cormier, Yuh-Fun Maa, Marika Kamberi, Peter Daddona
  • Trocar for inserting implants
    Patent number: 7329242
    Abstract: An implant retention trocar includes a cannula for puncturing the skin of an animal and an obturator for delivering the implant beneath the skin of the animal. The implant retention trocar has a cannula distal tip design which causes a minimum of trauma and tearing of tissue during implant insertion. A spring element received within the cannula prevents an implant which is to be inserted into an animal from falling out of the cannula during the implant insertion process. The spring element includes a longitudinal leg which is folded with a zigzag-shaped bend. When the spring element is inserted into the cannula, the zigzag-shaped bend of the longitudinal leg retains the implant within the cannula.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: February 12, 2008
    Assignee: Alza Corporation
    Inventor: John R. Peery
  • Transdermal warfarin system
    Patent number: 7323191
    Abstract: Composition of matter for application to a body surface or membrane to administer warfarin by permeation through the body surface or membrane, the composition comprising warfarin to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the warfarin or warfarin and enhancer composition and methods for the transdermal administration of the warfarin and warfarin/enhancer composition.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: January 29, 2008
    Assignee: Alza Corporation
    Inventor: Robert M. Gale
  • Method for the Management of Incontinence
    Publication number: 20080021102
    Abstract: A composition and a dosage form are disclosed comprising oxybutynin alone/or accompanied by another drug indicated for therapy. A method is disclosed for administering oxybutynin alone/or accompanied by a different drug or for administering oxybutynin and a different drug according to a therapeutic program for the management of incontinence alone, and for other therapy.
    Type: Application
    Filed: July 25, 2007
    Publication date: January 24, 2008
    Applicant: Alza Corporation
    Inventors: George Guittard, Francisco Jao, Susan Marks, David Kidney, Fernando Gumucio, Suneel Gupta, Gayatri Sathyan
  • Minimization of drug oxidation in drug irradiated excipients formulations
    Patent number: 7318936
    Abstract: This invention relates to compositions and methods for preventing oxidation of beneficial agents.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: January 15, 2008
    Assignee: Alza Corporation
    Inventors: Zhongli Ding, Lothar Walter Kleiner
  • Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
    Publication number: 20080009782
    Abstract: Electrotransport drug delivery devices, systems and methods for delivery of lofentanil or carfentanil are disclosed. The lofentanil or carfentanil may be provided as a water soluble salt (e.g., lofentanil or carfentanil hydrochloride), such as in a hydrogel formulation. A transdermal, electrotransport delivered dose of lofentanil or carfentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from chronic, acute and/or breakthrough pain.
    Type: Application
    Filed: June 26, 2007
    Publication date: January 10, 2008
    Applicant: ALZA Corporation
    Inventors: Robert Gale, Rama Padmanabhan, Joseph Phipps
  • VAGUS NERVE STIMULATION VIA ORALLY DELIVERED APPARATUS
    Publication number: 20080004671
    Abstract: Apparatus, systems and methods for stimulation of a vagus nerve of a patient are disclosed. An element that can be deployed and retained inside the patient's stomach without surgery and having a power supply and electrodes is associated with the expandable element. The electrodes are capable of stimulating the vagus nerve while the expandable element remains in the stomach for an extended period of time.
    Type: Application
    Filed: June 26, 2007
    Publication date: January 3, 2008
    Applicant: ALZA Corporation
    Inventors: Rolfe Anderson, Pedro E. de la Serna, Laura Maurer
  • MICROPROJECTION ARRAY APPLICATION WITH MULTILAYERED MICROPROJECTION MEMBER FOR HIGH DRUG LOADING
    Publication number: 20070299388
    Abstract: A transdermal drug delivery system with microprojections for disrupting a body surface to an individual. At least some of the microprojections arise from a first microprojection layer and at least some of the microprojections arise from a second microprojection layer. The first and second microprojection layers are stacked together.
    Type: Application
    Filed: April 25, 2007
    Publication date: December 27, 2007
    Applicant: ALZA CORPORATION
    Inventors: Keith Chan, Rajan Patel, Peter Daddona, Cedric Wright, Neha Agarwal
  • Microprojection Array Application with Grouped Microprojections for High Drug Loading
    Publication number: 20070293816
    Abstract: A transdermal drug delivery system with microprojections for disrupting a body surface to an individual. At least some of the microprojections form groups in a microprojection array. There are repeated units of such groups in the microprojection array.
    Type: Application
    Filed: April 25, 2007
    Publication date: December 20, 2007
    Applicant: ALZA CORPORATION
    Inventors: Keith Chan, Rajan Patel, Peter Daddona, Cedric Wright, Neha Agarwal
  • Microprojection Array Application with Sculptured Microprojections for High Drug Loading
    Publication number: 20070293815
    Abstract: A transdermal drug delivery system with microprojections for disrupting a body surface to an individual. At least some of the microprojections have a depression for increasing drug loading by a drug coating.
    Type: Application
    Filed: April 25, 2007
    Publication date: December 20, 2007
    Applicant: ALZA CORPORATION
    Inventors: Keith Chan, Rajan Patel, Peter Daddona, Cedric Wright, Neha Agarwal
  • Two-Piece, Internal-Channel Osmotic Delivery System Flow Modulator
    Publication number: 20070281024
    Abstract: An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 6, 2007
    Applicant: ALZA CORPORATION
    Inventors: Scott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
  • Method for treating multi-drug resistant tumors
    Patent number: 7303760
    Abstract: Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: December 4, 2007
    Assignees: Alza Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Samuel Zalipsky, Alberto Gabizon
  • Device for transdermal electrotransport delivery of fentanyl and sufentanil
    Patent number: 7302293
    Abstract: The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (e.g., fentanyl hydrochloride), preferably in a hydrogel formulation, for use in an electrotransport device (10). In accordance with the present invention, a transdermal electrotransport delivered dose of fentanyl/sufentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: November 27, 2007
    Assignee: ALZA Corporation
    Inventors: Mary Southam, Keith J. Bernstein, Henk Noorduin
  • Microprojection Array Application With High Barrier Retainer
    Publication number: 20070255251
    Abstract: A transdermal drug delivery system with a high barrier retainer for holding a microprojection member for disrupting a body surface to an individual. The retainer is made of a high barrier material (such as metal) that is easily sterilizable, such as by heat, and can be used for keeping out contamination and maintaining the environment of the microprojection member.
    Type: Application
    Filed: March 9, 2007
    Publication date: November 1, 2007
    Applicant: ALZA CORPORATION
    Inventors: Martin Panchula, Ling-Kang Tong
  • Method of making a housing for drug delivery
    Patent number: 7287319
    Abstract: An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same time providing a means for conducting an electric current therethrough.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: October 30, 2007
    Assignee: ALZA Corporation
    Inventors: Wendy A. Young, Lothar W. Kleiner
  • Electrotransport Delivery of Nesiritide
    Publication number: 20070249988
    Abstract: The present invention provides methods and devices for the non-invasive, transdermal administration by electrotransport of nesiritide, or pharmaceutically acceptable nesiritide salts, to patients in need of treatment with nesiritide. The present invention also provides methods for the treatment of congestive heart failure that involve the administration of nesiritide, or pharmaceutically acceptable nesiritide salts, by electrotransport to patients that suffer from congestive heart failure.
    Type: Application
    Filed: March 26, 2007
    Publication date: October 25, 2007
    Applicant: ALZA CORPORATION
    Inventors: Rama V. Padmanabhan, Joseph Bradley Phipps