Abstract: Novel peptides represented by the following formulaR.sub.1 --A--B--C--D--Trp--Met--Y (1)wherein; R.sub.1 denotes pGlu, X--R.sub.2 --CO--, X being carboxyl or amino and R.sub.2 being lower alkylene of 1-6 carbon atoms, or ##STR1## A denotes Asp, Ala, or merely a chemical bond; B denotes Tyr(SO.sub.3 H) or Phe(NHSO.sub.3 H); C denotes Met or merely a chemical bond; D denotes Gly, D--Ala, or D--Trp; and Y denotes NH.sub.2, Asp--NH.sub.2, or Asp--Phe--NH.sub.2 ; with the proviso that Y is NH.sub.2 or Asp--NH.sub.2 when R.sub.1 is pGlu, HOOC--R.sub.2 --CO--, or ##STR2## B is Tyr(SO.sub.3 H), C is Met, and D is Gly, and pharmacologically acceptable salts thereof.
Abstract: This invention provides a peptide represented by the formulaR--Tyr(SO.sub.3 H)--Met--Gly--Trp--Met--Asp--W--NH.sub.2wherein R is HOOC--A--CO--Asp-- (wherein A is lower alkylene), pGlu--Asp--, HOOC--A--CO-- (wherein A is lower alkylene) or ##STR1## and W is Phe or N.sup..alpha. -lower alkyl-Phe, or a salt thereof, process for preparing the peptide and psychodepressant composition containing the peptide.The peptides of the invention are useful as psychodepressant drug, and especially effective for curing schizophrenia.
Abstract: A novel polyamine oxidase, polyamine oxidase PC-3, takes an important role participating in decomposition and metabolism and polyamines such as spermidine and spermine.
Abstract: A novel polyamine oxidase, polyamine oxidase AT-1, takes an important role participating in decomposition and metabolism of polyamines such as spermidine and spermine.
Abstract: This invention relates to a process for the determination of free fatty acids comprising a reaction system 1 in which acyl coenzyme A synthetase is allowed to act on the free fatty acids in the presence of adenosine triphosphate and coenzyme A to yield acyl coenzyme A and a reaction system 2 in which acyl coenzyme A oxidase is allowed to act on the acyl coenzyme A to form hydrogen peroxide, followed by the determination thereof, said process being characterized in that myokinase is added in the reaction system 1 to make it go rapidly to completion.
Abstract: A novel process for the production of cholecystokininpancreozymin C-terminal peptide amide sulfate esters in a high yield and through a simple operation is described. A protected peptide amide is reacted with sulfur trioxide-pyridine complex and resulting protected piptide amide sulfate ester is then isolated in the form of its calcium salt. Thereafter, the protecting groups and calcium are removed. Sulfuric acid resulting from unreacted sulfur trioxide-pyridine complex may be precipitated and easily removed in the form of calcium sulfate.
Abstract: Acyl-CoA synthetase, having a high activity to C.sub.16 -C.sub.18 long chain fatty acids, is obtained by cultivating Pseudomonas aeruginosa IFO 3919. Pseudomonas aeruginosa IFO 3919 can produce acyl-CoA synthetase LCF-18 in large quantities, and the acyl-CoA synthetase LCF-18 produced by Pseudomonas aeruginosa IFO 3919 is very stable in storage.
Type:
Grant
Filed:
March 20, 1980
Date of Patent:
May 26, 1981
Assignee:
Amano Pharmaceutical Co. Ltd.
Inventors:
Hideaki Yamada, Sakayu Shimizu, Yoshiki Tani
Abstract: Acyl-CoA synthetase, having a high activity to C.sub.16 -C.sub.18 long chain fatty acids, is obtained by culturing strains belonging to various genera. As is known, acyl-CoA synthetase, having a strong activity to C.sub.16 -C.sub.18 long chain fatty acids, is generally obtained from liver of rat; however, it has now been discovered that acyl-CoA synthetase can be obtained from microorganisms and this enzyme is called acyl-CoA synthetase LCF-18. By use of acyl-CoA synthetase LCF-18 of the present invention which has a high activity to C.sub.16 -C.sub.18 long chain fatty acids, serum non-esterified fatty acid of human beings can be accurately determined, and it is very useful for diagnosis of diabetes and so forth.
Type:
Grant
Filed:
April 9, 1979
Date of Patent:
October 21, 1980
Assignee:
Amano Pharmaceutical Co. Ltd.
Inventors:
Hideaki Yamada, Sakayu Shimizu, Yoshiki Tani
Abstract: Aeromonas sp. No. 212 is cultured to allow it to produce a novel cellulase 212 and/or novel hemicellulase in a culture medium, and the so produced cellulase 212 and/or hemicellulase 333 is separated from the culture medium.The so separated novel cellulase 212 and/or novel hemicellulase 333 is used as a cellulosic material-decomposing agent in purifying tanks, plants for treatment of industrial waste waters, excrement treatment plants, drainage disposal treatment plants and the like.
Type:
Grant
Filed:
November 8, 1974
Date of Patent:
September 28, 1976
Assignee:
Amano Pharmaceutical Co., Ltd.
Inventors:
Takaichi Ohya, Nobumasa Yokoi, Tamio Mase
Abstract: A lipid metabolism improving and anti-atheromatic agent comprises as an active ingredient a new lipolytic substance GA-56 capable of specifically decomposing chylomicron and low-density lipoprotein and having high intestinal absorbability.