Abstract: The present disclosure provides a trans-splicing molecule that has a trifunctional element suitable for targeted trans-splicing of an RNA or pre-mRNA molecule.
Type:
Grant
Filed:
January 23, 2026
Date of Patent:
July 21, 2026
Assignee:
Amber Bio Inc.
Inventors:
Jacob Borrajo, Brigit Riley, Kamyab Javanmardi, Patricia Biezonski, Samuel Demario
Abstract: The present disclosure provides compositions and methods of use thereof for targeting trans-splicing of a pre-mRNA in a cell utilizing small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), and related methods.
Type:
Grant
Filed:
November 5, 2024
Date of Patent:
June 16, 2026
Assignee:
Amber Bio Inc.
Inventors:
Jacob Borrajo, Sam Demario, Kamyab Javanmardi, David Yao, Brigit Riley
Abstract: The disclosure relates to compositions and methods that modify target nucleic acids, as well as methods of detecting nucleic acids. Various compositions are described herein, including compositions comprising endonucleases, endonuclease systems, and chimeric proteins having the endonuclease and a nucleic-acid modulating domain or a nucleic acid modifying domain.
Type:
Grant
Filed:
November 24, 2023
Date of Patent:
July 8, 2025
Assignee:
Amber Bio Inc.
Inventors:
Basem Al-Shayeb, Jacob Borrajo, Mohammad Kamyab Javanmardi, Kushagra Sharma
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