Abstract: Provided herein are compositions and methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions with chemosensory receptor ligands. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
Type:
Grant
Filed:
April 20, 2010
Date of Patent:
February 27, 2018
Assignee:
AMBRA BIOSCIENCE LLC
Inventors:
Alain Baron, Martin R. Brown, Christopher R. J. Jones
Abstract: Provided herein are methods for treating diabetes, obesity, and other metabolic diseases, disorders or conditions comprising chemosensory receptor ligands. Also provided herein are chemosensory receptor ligand compositions and the preparation thereof for the methods of the present invention.
Type:
Grant
Filed:
September 8, 2014
Date of Patent:
December 27, 2016
Assignee:
AMBRA BIOSCIENCE LLC
Inventors:
Alain Baron, Martin R. Brown, Christopher R. G. Jones
Abstract: Provided herein are methods of modulating hormone concentrations in a subject comprising the administration of a composition comprising a chemosensory receptor ligand, wherein the composition is adapted to deliver the ligand to one or more regions of the intestine of said subject. Also provided are methods directed to the modulation of circulating concentrations of one or more of GLP-1 (total), GLP-1 (active), GLP-2, oxyntomodulin, PYY (total), PYY 3-36, CCK, GIP, insulin, C-peptide, glycentin, uroguanylin amylin, and ghrelin (total), ghrelin (active) and glucagon.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
November 8, 2016
Assignee:
AMBRA BIOSCIENCE LLC
Inventors:
Alain D. Baron, Martin R. Brown, Christopher R. G. Jones, Mark S. Fineman