Abstract: The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.
Type:
Grant
Filed:
April 14, 1992
Date of Patent:
November 21, 1995
Assignee:
Amergen, Inc.
Inventors:
Somesh D. Sharma, Brian R. Clark, Bernard L. Lerch