Abstract: An automated calibration system that includes a probe guide and a target assembly. The probe guide receives an optical probe, and the target assembly includes one or more calibration targets. The target assembly is slideable relative to the probe guide so that a first calibration target is aligned under the optical probe in a first position of the target assembly and a second calibration target is aligned under the optical probe in a second position of the target assembly.
Type:
Grant
Filed:
June 18, 2018
Date of Patent:
February 16, 2021
Assignees:
NORTHWESTERN UNIVERSITY, AMERICAN BIOOPTICS, LLC
Inventors:
Vadim Backman, Bradley Gould, Nikhil Mutyal, Frank Garrett, Jr., The Quyen Nguyen, Michael Garrett
Abstract: A pre-fabricated, on-demand interface provides optical coupling between disposable and reusable portions of a fiber-optic probe. The interface uses a pre-cured, compressible optically-transmissive gel in a cavity of the disposable portion, which can be a disposable insertion tip of the fiber optic probe. The disposable portion includes an elongated housing, or sheath, and the cavity is located within and proximal of a distal end of the elongated housing. A proximal end of an optical assembly of the disposable portion is located within the cavity and contacts the gel. A first coupling, provided at a proximal end of the elongated housing, detachably couples to a mating, second coupling of the probe reusable portion. When the disposable and reusable portions are coupled together, the gel is compressed between the proximal end of the optical assembly of the disposable portion and a distal optical member of an optical assembly of the reusable portion.
Type:
Grant
Filed:
March 4, 2015
Date of Patent:
January 5, 2021
Assignees:
Northwestern University, American Biooptics LLC
Inventors:
Vadim Backman, Bradley Gould, Andrew J. Cittadine, Nikhil Mutyal
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
Type:
Grant
Filed:
February 1, 2018
Date of Patent:
June 16, 2020
Assignees:
NORTHWESTERN UNIVERSITY, AMERICAN BIOOPTICS, LLC
Inventors:
Vadim Backman, Jeremy D. Rogers, Nikhil N. Mutyal, Bradley Gould, Andrew J. Radosevich, The Quyen Nguyen
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
Type:
Application
Filed:
February 1, 2018
Publication date:
June 28, 2018
Applicants:
NORTHWESTERN UNIVERSITY, AMERICAN BIOOPTICS LLC
Inventors:
Vadim Backman, Jeremy D. Rogers, Nikhil N. Mutyal, Bradley Gould, Andrew J. Radosevich
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
Type:
Grant
Filed:
August 9, 2013
Date of Patent:
February 6, 2018
Assignees:
NORTHWESTERN UNIVERSITY, AMERICAN BIOOPTICS LLC
Inventors:
Vadim Backman, Jeremy D. Rogers, Nikhil N. Mutyal, Bradley Gould, Andrew J. Radosevich
Abstract: The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light.
Type:
Application
Filed:
January 8, 2010
Publication date:
October 14, 2010
Applicants:
American Biooptics LLC, Northshore University Healthsystem, Northwestern University
Inventors:
Vadim Backman, Bradley Gould, Andrew Cittadine, Jeremy Rogers, Hemant Roy