Abstract: A DNA sequence encoding a novel human growth factor receptor referred to as a type III receptor tyrosine kinase is described. The amino acid sequence of the receptor is also described. The receptor has a sequence which is similar to that of the kinase domains of known type III receptor tyrosine kinases, but which is unique in its kinase insert domain sequence. The receptor binds specifically to the vascular endothelial cell growth factor.
Type:
Grant
Filed:
November 23, 1992
Date of Patent:
January 19, 1999
Assignee:
American Cayanamid Company
Inventors:
Bruce Israel Terman, Miguel Eduardo Carrion