Patents Assigned to American Home Products Corporation
  • Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
    Patent number: 6335350
    Abstract: Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: January 1, 2002
    Assignee: American Home Products Corporation
    Inventors: Jonathan Bloom, Martin DiGrandi, Russell Dushin, Stanley Lang, Bryan O'Hara
  • Extended release formulation
    Publication number: 20010055612
    Abstract: This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.
    Type: Application
    Filed: June 19, 2001
    Publication date: December 27, 2001
    Applicant: American Home Products Corporation Five Giralda Farms
    Inventors: Deborah M. Sherman, John C. Clark, John U. Lamer, Steven A. White
  • New treatments using venlafaxine
    Publication number: 20010053799
    Abstract: This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: 1
    Type: Application
    Filed: June 27, 2001
    Publication date: December 20, 2001
    Applicant: American Home Products Corporation
    Inventors: Richard L. Rudolph, Albert T. Derivan, Eric A. Muth, G. Virginia Upton
  • Water soluble SDZ RAD esters
    Patent number: 6331547
    Abstract: This invention provides novel water soluble pegylated esters of rapamycin, having the general structure: wherein n is an integer from about 5 to about 450, as well as pharmaceutical compositions containing these compounds and methods for their use as immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumor agents.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: December 18, 2001
    Assignee: American Home Products Corporation
    Inventors: Tianmin Zhu, Syed M. Shah, Richard W. Saunders
  • Tricyclic protein kinase inhibitors
    Publication number: 20010051620
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: December 29, 2000
    Publication date: December 13, 2001
    Applicant: American Home Products Corporation
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • 2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives
    Publication number: 20010051622
    Abstract: This invention provides compounds of formula I, 1
    Type: Application
    Filed: June 26, 2001
    Publication date: December 13, 2001
    Applicant: American Home Products Corporation
    Inventors: Sharon J. Rosenzweig-Lipson, Annmarie L. Sabb, Gregory S. Welmaker, James A. Nelson
  • Combination regimens using 3,3-substituted indoline derivatives
    Patent number: 6329416
    Abstract: This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds that are antagonists of the progesterone receptor having the general structure: wherein: R1, and R2 are chosen independently from each other from H, OH; OAc; alkylaryl; alkylheteroaryl; 1-propynyl; 3-propynyl; and optionally substituted alkyl, O(alkyl); aryl; or heteroaryl groups; or R1 and R2 are joined to FORM a ring comprising —CH2(CH2)nCH2— where n=0-5; —CH2CH2CMe2CH2CH2—; —O(CH2)mCH2— where m=1-4; O(CH2)pO— where p=1-4; —CH2CH2OCH2CH2—; —CH2CH2N(H or alkyl)CH2CH2—; or R1, and R2 together comprise a double bond to CMe2; C(cycloalkyl), O, or C(cycloether); R3 is H, OH, NH2, CORA; or optionally substituted alkenyl or alkynyl groups; RA=H or optionally substituted alkyl, alkoxy, or aminoalkyl groups; R4=H, halo, CN, NH2, or optionally substituted alkyl, alkoxy, or amino
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: December 11, 2001
    Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.
    Inventors: Gary S. Grubb, John W. Ullrich, Andrew Fensome, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
  • Rapamycin position 27 conjugates
    Patent number: 6328970
    Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: December 11, 2001
    Assignee: American Home Products Corporation
    Inventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain, Amadeo A. Failli
  • Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
    Patent number: 6326381
    Abstract: Compounds of the formula wherein R1, R2, R3, R4, X and n are defined in the specification, are useful for the treatment of anxiety, depression and related CNS disorders, and other related conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and Alzheimer's disease.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: December 4, 2001
    Assignee: American Home Products Corporation
    Inventors: Michael G. Kelly, Gan Zhang, Yvette L. Palmer, Wayne E. Childers
  • Anti-estrogen plus progestin containing oral contraceptives
    Patent number: 6326392
    Abstract: This invention provides a method of providing contraception which comprises administering to a female of child bearing age a combination of a non-uterotrophic anti-estrogen and a progestin for 28 days per 28-day menstrual cycle.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: December 4, 2001
    Assignee: American Home Products Corporation
    Inventors: Michael J. Gast, Christopher P. Miller
  • 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
    Patent number: 6326367
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: December 4, 2001
    Assignee: American Home Products Corporation
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
    Publication number: 20010047026
    Abstract: Compounds of the Formulae (I) and (II): 1
    Type: Application
    Filed: June 25, 2001
    Publication date: November 29, 2001
    Applicant: American Home Products Corporation
    Inventors: Schuyler A. Antane, John A. Butera, Joseph R. Lennox
  • Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
    Patent number: 6319912
    Abstract: This invention relates to cyclic combination therapies utilizing, in combination with a progestin, an estrogen, or both, progesterone receptor antagonists of the general structure: wherein the substituents are as defined herein, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: November 20, 2001
    Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.
    Inventors: Gary S. Grubb, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley, Mark A. Collins, Valerie A. Mackner, Jay E. Wrobel
  • Diaminopyrazoles
    Patent number: 6319941
    Abstract: This invention concerns the treatment of smooth muscle spasticity or excess muscle contraction such as urge urinary incontinence with a compound of the formula wherein: R1 and R2 are independently straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbons atoms, or cycloalkyl of 3 to 6 carbons atoms where R1 and R2 may be substituted by F, Cl, Br, I, OH, NH2, cyano, C1-C6 alkoxy, C1-C6alkylthio, COOH or COOC1-C6 alkyl; R3 is an aryl or heteroaryl as defined herein, optionally substituted with 0 to 4 groups selected independently from C1-C6 alkyl, C1-C6 alkoxy, cyano, F, Cl, Br, C1-C6 alkylthio, CO2R1, CONH2, OH, NH2, and NO2; n is 0 or 1; R4 is a straight chain alkyl group of 1 to 10 carbons atoms, a branched alkyl of 3 to 10 carbons, or a cycloalkyl of 3 to 10 carbons; and all crystalline forms and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: November 20, 2001
    Assignee: American Home Products Corporation
    Inventors: Adam Matthew Gilbert, Zhen-jia Chen
  • Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
    Patent number: 6316467
    Abstract: Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: November 13, 2001
    Assignee: American Home Products Corporation
    Inventor: Thomas J. Commons
  • Regioselective synthesis of rapamycin derivatives
    Publication number: 20010039338
    Abstract: This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
    Type: Application
    Filed: June 7, 2001
    Publication date: November 8, 2001
    Applicant: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, John Sellstedt, Razzak Noureldin, Gloria K. Cheal, Genevieve Fortier
  • Multi-composition stick product, such as lip balm, sun screen, deodorant, or glue stick
    Patent number: D452585
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: December 25, 2001
    Assignee: American Home Products Corporation
    Inventor: Jee Loon Look
  • Multi-composition stick product, such as lip balm, sun screen, deodorant, or glue stick
    Patent number: D452586
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: December 25, 2001
    Assignee: American Home Products Corporation
    Inventor: Jee Loon Look
  • Multi-composition stick product, such as lip balm, sun screen, deodorant, or glue stick
    Patent number: D452587
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: December 25, 2001
    Assignee: American Home Products Corporation
    Inventor: Jee Loon Look
  • Multi-composition stick product, such as lip balm, sun screen, deodorant, or glue stick
    Patent number: D452588
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: December 25, 2001
    Assignee: American Home Products Corporation
    Inventor: Jee Loon Look